Cathepsins and Their Endogenous Inhibitors in Host Defense During Mycobacterium tuberculosis and HIV Infection

by Elsa Anes, José Miguel Azevedo-Pereira, David Pires
Published 2021-08-01

HIV-2 interaction with macrophages and dendritic cells

by Marta Calado, David Pires, Elsa Anes, José M. Azevedo-Pereira
Published 2016-05-01

ESAT-6 a Major Virulence Factor of <i>Mycobacterium tuberculosis</i>

by Elsa Anes, David Pires, Manoj Mandal, José Miguel Azevedo-Pereira
Published 2023-06-01

Spatial localization of cathepsins: Implications in immune activation and resolution during infections

by Elsa Anes, David Pires, Manoj Mandal, José Miguel Azevedo-Pereira
Published 2022-08-01

Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant <i>Mycobacterium tuberculosis</i>

by Manoj Mandal, David Pires, Maria João Catalão, José Miguel Azevedo-Pereira, Elsa Anes
Published 2023-07-01

Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria.

by Paras K Anand, Ellis Anand, Christopher K E Bleck, Elsa Anes, Gareth Griffiths
Published 2010-04-01

Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection

by David Pires, Sofia Valente, Marta Calado, Manoj Mandal, José Miguel Azevedo-Pereira, Elsa Anes
Published 2021-03-01

Nitrobenzoates and Nitrothiobenzoates with Activity against <i>M. tuberculosis</i>

by João P. Pais, Olha Antoniuk, Raquel Freire, David Pires, Emília Valente, Elsa Anes, Luis Constantino
Published 2023-04-01

HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an “Emerging Syndemic”

by José Miguel Azevedo-Pereira, David Pires, Marta Calado, Manoj Mandal, Quirina Santos-Costa, Elsa Anes
Published 2023-03-01

Cell-to-Cell Transmission of HIV-1 and HIV-2 from Infected Macrophages and Dendritic Cells to CD4+ T Lymphocytes

by Marta Calado, David Pires, Carolina Conceição, Rita Ferreira, Quirina Santos-Costa, Elsa Anes, José Miguel Azevedo-Pereira
Published 2023-04-01

Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages.

by Hridayesh Prakash, Anja Lüth, Natalia Grinkina, Daniela Holzer, Raj Wadgaonkar, Alexis Perez Gonzalez, Elsa Anes, Burkhard Kleuser
Published 2010-01-01

Synthesis, Activity, Toxicity, and In Silico Studies of New Antimycobacterial <i>N</i>-Alkyl Nitrobenzamides

by João P. Pais, Olha Antoniuk, David Pires, Tiago Delgado, Andreia Fortuna, Paulo J. Costa, Elsa Anes, Luis Constantino
Published 2024-05-01

Development of New Drugs to Treat Tuberculosis Based on the Dinitrobenzamide Scaffold

by Tiago Delgado, João P. Pais, David Pires, Filipe G. A. Estrada, Rita C. Guedes, Elsa Anes, Luis Constantino
Published 2024-04-01

Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.

by Diana Machado, David Pires, João Perdigão, Isabel Couto, Isabel Portugal, Marta Martins, Leonard Amaral, Elsa Anes, Miguel Viveiros
Published 2016-01-01

Fluoroquinolone Derivatives in the Treatment of <i>Mycobacterium tuberculosis</i> Infection

by João Pedro Pais, Margarida Policarpo, David Pires, Ana Paula Francisco, Ana Margarida Madureira, Bernard Testa, Elsa Anes, Luís Constantino
Published 2022-09-01

Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation

by David Pires, Elliott M. Bernard, João Palma Pombo, Nuno Carmo, Catarina Fialho, Maximiliano Gabriel Gutierrez, Paulo Bettencourt, Elsa Anes
Published 2017-12-01

Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by <i>Mycobacterium tuberculosis</i> and Helps Control the Phagosomal Replicative Niches

by David Pires, Manoj Mandal, Jacinta Pinho, Maria João Catalão, António José Almeida, José Miguel Azevedo-Pereira, Maria Manuela Gaspar, Elsa Anes
Published 2023-01-01

Benzoic Acid Derivatives as Prodrugs for the Treatment of Tuberculosis

by João P. Pais, Marta Magalhães, Olha Antoniuk, Ivete Barbosa, Raquel Freire, David Pires, Emília Valente, Bernard Testa, Elsa Anes, Luis Constantino
Published 2022-09-01

CRISPRi-mediated characterization of novel anti-tuberculosis targets: Mycobacterial peptidoglycan modifications promote beta-lactam resistance and intracellular survival

by Cátia Silveiro, Mariana Marques, Francisco Olivença, David Pires, David Pires, Diana Mortinho, Alexandra Nunes, Alexandra Nunes, Madalena Pimentel, Elsa Anes, Maria João Catalão
Published 2023-03-01

Development of Chitosan Particles Loaded with siRNA for Cystatin C to Control Intracellular Drug-Resistant <i>Mycobacterium tuberculosis</i>

by David Pires, Manoj Mandal, Ana I. Matos, Carina Peres, Maria João Catalão, José Miguel Azevedo-Pereira, Ronit Satchi-Fainaro, Helena F. Florindo, Elsa Anes
Published 2023-04-01