Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function

by Per Anderson, Elena Gonzalez-Rey, Francisco O’Valle, Francisco Martin, F. Javier Oliver, Mario Delgado
Published 2017-01-01

CORTISTATIN AS AN ENDOGENOUS REGULATOR OF NEUROINFLAMMATION AND NEURODEGENERATION IN AGING

by Ignacio Serrano Martínez, Julia Castillo González, Pablo Vargas-Rodríguez, Irene Forte Lago, Elena Gonzalez-Rey
Published 2023-10-01

GENERATION AND CHARACTERIZATION OF A NOVEL PRECLINICAL MODEL FOR INVESTIGATING STROKE RISK FACTORS AND THERAPIES

by Pablo Vargas-Rodríguez, Julia Castillo González, Ignacio Serrano Martínez, Irene Forte Lago, Elena Gonzalez-Rey
Published 2023-10-01

Therapeutic effect of a poly(ADP-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating inflammation and Th1 response.

by Elena Gonzalez-Rey, Ruben Martínez-Romero, Francisco O'Valle, Rocío Aguilar-Quesada, Carmen Conde, Mario Delgado, F Javier Oliver
Published 2007-01-01

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania.

by Jenny Campos-Salinas, David León-Guerrero, Elena González-Rey, Mario Delgado, Santiago Castanys, José M Pérez-Victoria, Francisco Gamarro
Published 2013-01-01

Correction: LABCG2, a New ABC Transporter Implicated in Phosphatidylserine Exposure, Is Involved in the Infectivity and Pathogenicity of.

by Jenny Campos-Salinas, David León-Guerrero, Elena González-Rey, Mario Delgado, Santiago Castanys, José M. Pérez-Victoria, Francisco Gamarro
Published 2013-06-01

Human Bone Marrow Stromal Cells Lose Immunosuppressive and Anti-inflammatory Properties upon Oncogenic Transformation

by Rene Rodriguez, Michael Rosu-Myles, Marcos Aráuzo-Bravo, Angélica Horrillo, Qiuwei Pan, Elena Gonzalez-Rey, Mario Delgado, Pablo Menendez
Published 2014-10-01

Novel Therapeutic Opportunities for Neurodegenerative Diseases with Mesenchymal Stem Cells: The Focus on Modulating the Blood-Brain Barrier

by Pablo Vargas-Rodríguez, Alejandro Cuenca-Martagón, Julia Castillo-González, Ignacio Serrano-Martínez, Raúl M. Luque, Mario Delgado, Elena González-Rey
Published 2023-09-01

THE NEUROPEPTIDE CORTISTATIN, A CRUCIAL MODULATOR IN THE IMMUNE DYSREGULATION AND BLOOD-BRAIN BARRIER DYSFUNCTION UNDERLYING ISCHEMIC BRAIN INJURY

by Julia Castillo González, Lara Buscemi, Ignacio Serrano Martínez, Irene Forte Lago, Marta Caro, Pedro Hernández Cortés, Lorenz Hirt, Elena Gonzalez-Rey
Published 2023-10-01

Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases

by Ana Isabel Sánchez-Castillo, M. Rosario Sepúlveda, José Luis Marín-Teva, Miguel A. Cuadros, David Martín-Oliva, Elena González-Rey, Mario Delgado, Veronika E. Neubrand
Published 2022-01-01

Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.

by Cintia Roodveldt, Adahir Labrador-Garrido, Elena Gonzalez-Rey, Rafael Fernandez-Montesinos, Marta Caro, Christian C Lachaud, Christopher A Waudby, Mario Delgado, Christopher M Dobson, David Pozo
Published 2010-10-01

The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury

by Clara P. Falo, Raquel Benitez, Marta Caro, Maria Morell, Irene Forte-Lago, Pedro Hernandez-Cortes, Clara Sanchez-Gonzalez, Francisco O’Valle, Mario Delgado, Elena Gonzalez-Rey
Published 2021-06-01

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48

by Marta Martínez-García, Jean-Mathieu Bart, Jenny Campos-Salinas, Eva Valdivia, Manuel Martínez-Bueno, Elena González-Rey, Miguel Navarro, Mercedes Maqueda, Rubén Cebrián, José M. Pérez-Victoria
Published 2018-08-01

Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.

by Cintia Roodveldt, Adahir Labrador-Garrido, Elena Gonzalez-Rey, Christian C Lachaud, Tim Guilliams, Rafael Fernandez-Montesinos, Alicia Benitez-Rondan, Gema Robledo, Abdelkrim Hmadcha, Mario Delgado, Christopher M Dobson, David Pozo
Published 2013-01-01

THE NEUROPEPTIDE CORTISTATIN REGULATES THE PROGRAMMING OF BRAIN ENDOTHELIAL CELLS UNDER PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS

by Elena Gonzalez-Rey, José Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodríguez, Marta Caro, Jesús Pérez-Gómez, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl Luque, Julia Castillo-González
Published 2023-10-01

Cortistatin as a Novel Multimodal Therapy for the Treatment of Parkinson’s Disease

by Ignacio Serrano-Martínez, Marta Pedreño, Julia Castillo-González, Viviane Ferraz-de-Paula, Pablo Vargas-Rodríguez, Irene Forte-Lago, Marta Caro, Jenny Campos-Salinas, Javier Villadiego, Pablo Peñalver, Juan Carlos Morales, Mario Delgado, Elena González-Rey
Published 2024-01-01

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

by Álvaro Rol, Toni Todorovski, Pau Martin-Malpartida, Anna Escolà, Elena Gonzalez-Rey, Eric Aragón, Xavier Verdaguer, Mariona Vallès-Miret, Josep Farrera-Sinfreu, Eduard Puig, Jimena Fernández-Carneado, Berta Ponsati, Mario Delgado, Antoni Riera, Maria J. Macias
Published 2021-03-01

Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity

by Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque, Elena González-Rey
Published 2023-10-01

Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution...

by Rafael Diaz de la Guardia, Belen Lopez-Millan, Heleia Roca-Ho, Clara Bueno, Francisco Gutiérrez-Agüera, Jose Luis Fuster, Eduardo Anguita, Samanta Romina Zanetti, Susana Vives, Josep Nomdedeu, Robert Sackstein, Jessie Lavoie, Elena Gónzalez-Rey, Mario Delgado, Michael Rosu-Myles, Pablo Menendez
Published 2019-02-01

Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis

by Fernando Cavalcanti, Elena Gonzalez-Rey, Mario Delgado, Clara P. Falo, Leyre Mestre, Carmen Guaza, Francisco O’Valle, Michele M. P. Lufino, Jordi Xaus, Cristina Mascaró, Serena Lunardi, Natalia Sacilotto, Paola Dessanti, David Rotllant, Xavier Navarro, Mireia Herrando-Grabulosa, Carlos Buesa, Tamara Maes
Published 2022-07-01