Chronic exposure to IFNα drives medullar lymphopoiesis towards T-cell differentiation in mice

by Marianna Di Scala, Irene Gil-Fariña, Lucia Vanrell, Rodrigo Sánchez-Bayona, Diego Alignani, Cristina Olagüe, Africa Vales, Pedro Berraondo, Jesús Prieto, Gloria González-Aseguinolaza
Published 2015-08-01

Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients

by Esperanza Martín-Sánchez, Esperanza Martín-Sánchez, Esperanza Martín-Sánchez, Esperanza Martín-Sánchez, Juan José Garcés, Juan José Garcés, Juan José Garcés, Juan José Garcés, Catarina Maia, Catarina Maia, Catarina Maia, Catarina Maia, Susana Inogés, Susana Inogés, Susana Inogés, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Francisco Carmona-Torre, Francisco Carmona-Torre, Francisco Carmona-Torre, Marta Marin-Oto, Félix Alegre, Elvira Molano, Mirian Fernandez-Alonso, Mirian Fernandez-Alonso, Cristina Perez, Cristina Perez, Cristina Perez, Cirino Botta, Aintzane Zabaleta, Aintzane Zabaleta, Aintzane Zabaleta, Aintzane Zabaleta, Ana Belen Alcaide, Manuel F. Landecho, Marta Rua, Teresa Pérez-Warnisher, Laura Blanco, Laura Blanco, Sarai Sarvide, Sarai Sarvide, Sarai Sarvide, Amaia Vilas-Zornoza, Amaia Vilas-Zornoza, Amaia Vilas-Zornoza, Diego Alignani, Diego Alignani, Diego Alignani, Diego Alignani, Cristina Moreno, Cristina Moreno, Cristina Moreno, Iñigo Pineda, Miguel Sogbe, Josepmaria Argemi, Bruno Paiva, Bruno Paiva, Bruno Paiva, Bruno Paiva, José Ramón Yuste, José Ramón Yuste, José Ramón Yuste
Published 2021-05-01

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironmen...

by Daniel Alameda, Borja Saez, David Lara-Astiaso, Sarai Sarvide, Marta Lasa, Diego Alignani, Idoia Rodriguez, Sonia Garate, Amaia Vilas, Bruno Paiva, Matias Alfonso-Olmos, Jose Maria Lamo de Espinosa, Felipe Prosper, Jesus F. San Miguel, Patricia Maiso
Published 2020-06-01

Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells

by Maria C. Ochoa, Elisabeth Perez-Ruiz, Luna Minute, Carmen Oñate, Guiomar Perez, Inmaculada Rodriguez, Aintzane Zabaleta, Diego Alignani, Myriam Fernandez-Sendin, Ascension Lopez, Aura Muntasell, Miguel F. Sanmamed, Bruno Paiva, Miguel Lopez-Botet, Pedro Berraondo, Ignacio Melero
Published 2019-07-01

Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination

by David Repáraz, David Repáraz, David Repáraz, Marta Ruiz, Marta Ruiz, Marta Ruiz, Leyre Silva, Leyre Silva, Leyre Silva, Belén Aparicio, Belén Aparicio, Belén Aparicio, Josune Egea, Josune Egea, Josune Egea, Elizabeth Guruceaga, Elizabeth Guruceaga, Daniel Ajona, Daniel Ajona, Daniel Ajona, Daniel Ajona, Yaiza Senent, Yaiza Senent, Yaiza Senent, Enrique Conde, Enrique Conde, Flor Navarro, Sergio Barace, Diego Alignani, Diego Alignani, Sandra Hervás-Stubbs, Sandra Hervás-Stubbs, Sandra Hervás-Stubbs, Juan José Lasarte, Juan José Lasarte, Diana Llopiz, Diana Llopiz, Diana Llopiz, Pablo Sarobe, Pablo Sarobe, Pablo Sarobe
Published 2022-10-01

Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia

by Miren Lasaga, Paula Río, Amaia Vilas-Zornoza, Nuria Planell, Susana Navarro, Diego Alignani, Beatriz Fernández-Varas, Daniel Mouzo, Josune Zubicaray, Roser M. Pujol, Eileen Nicoletti, Jonathan D. Schwartz, Julián Sevilla, Marina Ainciburi, Asier Ullate-Agote, Jordi Surrallés, Rosario Perona, Leandro Sastre, Felipe Prosper, David Gomez-Cabrero, Juan A. Bueren
Published 2023-04-01

Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

by Jin Ye, Isabel A. Calvo, Itziar Cenzano, Amaia Vilas, Xabier Martinez-de-Morentin, Miren Lasaga, Diego Alignani, Bruno Paiva, Ana C. Viñado, Patxi San Martin-Uriz, Juan P. Romero, Delia Quilez Agreda, Marta Miñana Barrios, Ignacio Sancho-González, Gabriele Todisco, Luca Malcovati, Nuria Planell, Borja Saez, Jesper N. Tegner, Felipe Prosper, David Gomez-Cabrero
Published 2022-05-01

Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of <i>KRAS</i>-mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating CD8⁺ T Cells

by Iosune Baraibar, Marta Roman, María Rodríguez-Remírez, Inés López, Anna Vilalta, Elisabeth Guruceaga, Margarita Ecay, María Collantes, Teresa Lozano, Diego Alignani, Ander Puyalto, Ana Oliver, Sergio Ortiz-Espinosa, Haritz Moreno, María Torregrosa, Christian Rolfo, Christian Caglevic, David García-Ros, María Villalba-Esparza, Carlos De Andrea, Silvestre Vicent, Rubén Pío, Juan José Lasarte, Alfonso Calvo, Daniel Ajona, Ignacio Gil-Bazo
Published 2020-10-01

Immunologic characterization of COVID-19 patients with hematological cancer

by Catarina Maia, Esperanza Martín-Sánchez, Juan José Garcés, Ascensión López-Díaz de Cerio, Susana Inogés, Manuel F. Landecho, Belén Gil-Alzugaray, Cristina Perez, Cirino Botta, Aintzane Zabaleta, Félix Alegre, César Rincón, Laura Blanco, Sarai Sarvide, Amaia Vilas-Zornoza, Diego Alignani, Cristina Moreno, Artur Paiva, António Martinho, Rui Alves, Enrique Colado, Covadonga Quirós, Mónica Olid, Andrés Blanco, Josepmaria Argemi, Bruno Paiva, José Ramón Yuste
Published 2020-12-01

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

by Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso-Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Lamo-Espinosa, Mikel San-Julian, Tamara Jiménez-Solas, Felix Lopez, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, David Gomez-Cabrero, Maria Diez-Campelo, David Valcarcel, Mikel Hernaez, Juan P Romero, Felipe Prosper
Published 2023-01-01

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma

by Yuji Mishima, Bruno Paiva, Jiantao Shi, Jihye Park, Salomon Manier, Satoshi Takagi, Mira Massoud, Adriana Perilla-Glen, Yosra Aljawai, Daisy Huynh, Aldo M. Roccaro, Antonio Sacco, Marzia Capelletti, Alexandre Detappe, Diego Alignani, Kenneth C. Anderson, Nikhil C. Munshi, Felipe Prosper, Jens G. Lohr, Gavin Ha, Samuel S. Freeman, Eliezer M. Van Allen, Viktor A. Adalsteinsson, Franziska Michor, Jesus F. San Miguel, Irene M. Ghobrial
Published 2017-04-01

The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes

by Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Published 2022-12-01