A Fast and Selective Approach for Profiling Vicinal Diols Using Liquid Chromatography-Post Column Derivatization-Double Precursor Ion Scanning Mass Spectrometry

by Debin Wan, Christophe Morisseau, Bruce D. Hammock, Jun Yang
Published 2022-01-01

A Soluble Epoxide Hydrolase Inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, Ameliorates Experimental Autoimmune Encephalomyelitis

by Deepa Jonnalagadda, Debin Wan, Jerold Chun, Bruce D. Hammock, Yasuyuki Kihara
Published 2021-04-01

Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain

by Nalin Singh, Bogdan Barnych, Karen M. Wagner, Debin Wan, Christophe Morisseau, Bruce D. Hammock
Published 2021-03-01

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors

by Sean D. Kodani, Debin Wan, Karen M. Wagner, Sung Hee Hwang, Christophe Morisseau, Bruce D. Hammock
Published 2018-10-01

TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function

by Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp
Published 2021-08-01

A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine

by Debin Wan, Jun Yang, Bogdan Barnych, Sung Hee Hwang, Kin Sing Stephen Lee, Yongliang Cui, Jun Niu, Mitchell A. Watsky, Bruce D. Hammock
Published 2017-04-01

Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways

by Kin Sing Stephen Lee, Jun Yang, Jun Niu, Connie J. Ng, Karen M. Wagner, Hua Dong, Sean D. Kodani, Debin Wan, Christophe Morisseau, Bruce D. Hammock
Published 2019-09-01

In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

by Debin Wan, Jun Yang, Cindy B. McReynolds, Bogdan Barnych, Karen M. Wagner, Christophe Morisseau, Sung Hee Hwang, Jia Sun, Jia Sun, René Blöcher, Bruce D. Hammock
Published 2019-05-01

Soluble Epoxide Hydrolase Inhibition by <i>t</i>-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

by Haley Overby, Yang Yang, Xinyun Xu, Katherine Graham, Kelsey Hildreth, Sue Choi, Debin Wan, Christophe Morisseau, Darryl C. Zeldin, Bruce D. Hammock, Shu Wang, Ahmed Bettaieb, Ling Zhao
Published 2020-09-01

Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor.

by Chuanzhen Zhang, Wei Li, Xiyuan Li, Debin Wan, Savannah Mack, Jingjing Zhang, Karen Wagner, Chang Wang, Bowen Tan, Jason Chen, Ching-Wen Wu, Kaori Tsuji, Minoru Takeuchi, Ziping Chen, Bruce D Hammock, Kent E Pinkerton, Jun Yang
Published 2022-01-01

Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor

by Chuanzhen Zhang, Wei Li, Xiyuan Li, Debin Wan, Savannah Mack, Jingjing Zhang, Karen Wagner, Chang Wang, Bowen Tan, Jason Chen, Ching-Wen Wu, Kaori Tsuji, Minoru Takeuchi, Ziping Chen, Bruce D. Hammock, Kent E. Pinkerton, Jun Yang
Published 2022-01-01

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

by Cindy B. McReynolds, Cindy B. McReynolds, Sung Hee Hwang, Sung Hee Hwang, Jun Yang, Jun Yang, Debin Wan, Karen Wagner, Karen Wagner, Christophe Morisseau, Dongyang Li, William K. Schmidt, Bruce D. Hammock, Bruce D. Hammock
Published 2019-05-01

CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury

by Matthieu Leuillier, Thomas Duflot, Séverine Ménoret, Hind Messaoudi, Zoubir Djerada, Déborah Groussard, Raphaël G.P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiébaut, Isabelle Schmitz-Afonso, Séverine Nobis, Cynthia Campart, Tiphaine Henry, Camille Sautreuil, Serge H. Luquet, Olivia Beseme, Catherine Féliu, Hélène Peyret, Lionel Nicol, Jean-Paul Henry, Sylvanie Renet, Paul Mulder, Debin Wan, Laurent Tesson, Jean-Marie Heslan, Angéline Duché, Sébastien Jacques, Frédéric Ziegler, Valéry Brunel, Gilles J.P. Rautureau, Christelle Monteil, Jean-Luc do Rego, Jean-Claude do Rego, Carlos Afonso, Bruce Hammock, Anne-Marie Madec, Florence Pinet, Vincent Richard, Ignacio Anegon, Christophe Guignabert, Christophe Morisseau, Jérémy Bellien
Published 2023-01-01