Gene expression meta-analysis identifies VDAC1 as a predictor of poor outcome in early stage non-small cell lung cancer.

by Claire Grills, Puthen V Jithesh, Jaine Blayney, Shu-Dong Zhang, Dean A Fennell
Published 2011-01-01

Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.

by Claire Grills, Nyree Crawford, Alex Chacko, Patrick G Johnston, Francesca O'Rourke, Dean A Fennell
Published 2008-08-01

Ultra-Fast Processing of Gigapixel Tissue MicroArray Images Using High Performance Computing

by Yinhai Wang, David McCleary, Ching-Wei Wang, Paul Kelly, Jackie James, Dean A. Fennell, Peter Hamilton
Published 2010-01-01

A TMA de-arraying method for high throughput biomarker discovery in tissue research.

by Yinhai Wang, Kienan Savage, Claire Grills, Andrena McCavigan, Jacqueline A James, Dean A Fennell, Peter W Hamilton
Published 2011-01-01

Corrigendum: CDKN2A determines mesothelioma cell fate to EZH2 inhibition

by Giulia Pinton, Zhuo Wang, Cecilia Balzano, Sara Missaglia, Daniela Tavian, Renzo Boldorini, Dean A. Fennell, Martin Griffin, Laura Moro
Published 2022-11-01

CDKN2A Determines Mesothelioma Cell Fate to EZH2 Inhibition

by Giulia Pinton, Zhuo Wang, Cecilia Balzano, Sara Missaglia, Daniela Tavian, Renzo Boldorini, Dean A. Fennell, Martin Griffin, Laura Moro
Published 2021-07-01

Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial

by Dean A. Fennell, Catharine Porter, Jason Lester, Sarah Danson, Fiona Blackhall, Marianne Nicolson, Lisette Nixon, Georgina Gardner, Ann White, Gareth Griffiths, Angela Casbard
Published 2022-10-01

Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.

by Dario Barbone, Loes Van Dam, Carlo Follo, Puthen V Jithesh, Shu-Dong Zhang, William G Richards, Raphael Bueno, Dean A Fennell, V Courtney Broaddus
Published 2016-01-01

Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression.

by Dario Barbone, Priscilla Cheung, Sailaja Battula, Sara Busacca, Steven G Gray, Daniel B Longley, Raphael Bueno, David J Sugarbaker, Dean A Fennell, V Courtney Broaddus
Published 2012-01-01

Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory resul...

by Dean A Fennell, Scott P Myrand, Tuan S Nguyen, David Ferry, Keith M Kerr, Perry Maxwell, Stephen D Moore, Carla Visseren-Grul, Mayukh Das, Marianne C Nicolson
Published 2014-01-01

Correction: Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature.

by Martin P Barr, Steven G Gray, Andreas C Hoffmann, Ralf A Hilger, Juergen Thomale, John D O'Flaherty, Dean A Fennell, Derek Richard, John J O'Leary, Kenneth J O'Byrne
Published 2020-01-01

Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature.

by Martin P Barr, Steven G Gray, Andreas C Hoffmann, Ralf A Hilger, Juergen Thomale, John D O'Flaherty, Dean A Fennell, Derek Richard, John J O'Leary, Kenneth J O'Byrne
Published 2013-01-01

Correction: BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma.

by Sara Busacca, Alex D. Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff, Dario Barbone, Luciano Mutti, Vignesh K. Gunasekharan, Julia J. Gorski, Mohamed El-Tanani, V. Courtney Broaddus, Giovanni Gaudino, Dean A. Fennell
Published 2013-01-01

BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma.

by Sara Busacca, Alex D Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff, Dario Barbone, Luciano Mutti, Vignesh K Gunasekharan, Julia J Gorski, Mohamed El-Tanani, V Courtney Broaddus, Giovanni Gaudino, Dean A Fennell
Published 2013-01-01

CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised c...

by Dean A. Fennell, Emma Kirkpatrick, Kelly Cozens, Mavis Nye, Jason Lester, Gerard Hanna, Nicola Steele, Peter Szlosarek, Sarah Danson, Joanne Lord, Christian Ottensmeier, Daniel Barnes, Stephanie Hill, Mihalis Kalevras, Tom Maishman, Gareth Griffiths
Published 2018-04-01

Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial

by Dean A. Fennell, Catharine Porter, Jason Lester, Sarah Danson, Paul Taylor, Michael Sheaff, Robin M Rudd, Aarti Gaba, Sara Busacca, Lisette Nixon, Georgina Gardner, Liz Darlison, Charlotte Poile, Cathy Richards, Peter-Wells Jordan, Gareth Griffiths, Angela Casbard
Published 2022-06-01

Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression

by Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G. Dawson, David A. Moore, David A. Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C. Boutros, Shu-Dong Zhang, Dean A. Fennell
Published 2021-04-01

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

by Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K Sage, Sabarinath Vallath, John Le Quesne, David A Tice, Doraid Alrifai, Sylvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A Fennell, Mathew Garnett, Francesco Iorio, Lodewyk Wessels, Ultan McDermott, Samuel M Janes
Published 2018-01-01

Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

by Jenette Creaney, Ann-Marie Patch, Venkateswar Addala, Sophie A. Sneddon, Katia Nones, Ian M. Dick, Y. C. Gary Lee, Felicity Newell, Ebony J. Rouse, Marjan M. Naeini, Olga Kondrashova, Vanessa Lakis, Apostolos Nakas, David Waller, Annabel Sharkey, Pamela Mukhopadhyay, Stephen H. Kazakoff, Lambros T. Koufariotis, Aimee L. Davidson, Priya Ramarao-Milne, Oliver Holmes, Qinying Xu, Conrad Leonard, Scott Wood, Sean M. Grimmond, Raphael Bueno, Dean A. Fennell, John V. Pearson, Bruce W. Robinson, Nicola Waddell
Published 2022-05-01

Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

by Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G. Dawson, Apostolos Nakas, Sara Busacca, Annabel J. Sharkey, David Waller, Michael T. Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y. Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martison, Jacqui A. Shaw, Catrin Pritchard, Tamihiro Kamata, Nathaniel Kuse, Lee Brannan, Pan De Philip Zhang, Hongji Yang, Gareth Griffiths, Gareth Wilson, Charles Swanton, Frank Dudbridge, Edward J. Hollox, Dean A. Fennell
Published 2021-03-01