Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling

by Anna Paszek, Małgorzata Kardyńska, James Bagnall, Jarosław Śmieja, David G. Spiller, Piotr Widłak, Marek Kimmel, Wieslawa Widlak, Pawel Paszek
Published 2020-05-01

Live-cell imaging reveals single-cell and population-level infection strategies of Listeria monocytogenes in macrophages

by Josephine Moran, Liam Feltham, James Bagnall, Marie Goldrick, Elizabeth Lord, Catherine Nettleton, David G. Spiller, Ian Roberts, Pawel Paszek
Published 2023-08-01

Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.

by Luke W Thomas, Connie Lam, Richard E Clark, Michael R H White, David G Spiller, Robert J Moots, Steven W Edwards
Published 2012-01-01

Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis

by Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Published 2019-06-01

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

by Eirini Kalliara, Eirini Kalliara, Malgorzata Kardynska, Malgorzata Kardynska, James Bagnall, David G. Spiller, Werner Müller, Dominik Ruckerl, Jarosław Śmieja, Subhra K. Biswas, Pawel Paszek
Published 2022-09-01

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

by Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Published 2023-05-01

Dynamic analysis of stochastic transcription cycles.

by Claire V Harper, Bärbel Finkenstädt, Dan J Woodcock, Sönke Friedrichsen, Sabrina Semprini, Louise Ashall, David G Spiller, John J Mullins, David A Rand, Julian R E Davis, Michael R H White
Published 2011-04-01

Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

by Nick E Phillips, Cerys S Manning, Tom Pettini, Veronica Biga, Elli Marinopoulou, Peter Stanley, James Boyd, James Bagnall, Pawel Paszek, David G Spiller, Michael RH White, Marc Goodfellow, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Published 2016-10-01

Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

by John M Ankers, Raheela Awais, Nicholas A Jones, James Boyd, Sheila Ryan, Antony D Adamson, Claire V Harper, Lloyd Bridge, David G Spiller, Dean A Jackson, Pawel Paszek, Violaine Sée, Michael RH White
Published 2016-05-01

Disentangling juxtacrine from paracrine signalling in dynamic tissue.

by Hiroshi Momiji, Kirsty L Hassall, Karen Featherstone, Anne V McNamara, Amanda L Patist, David G Spiller, Helen C Christian, Michael R H White, Julian R E Davis, Bärbel F Finkenstädt, David A Rand
Published 2019-06-01

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

by Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek
Published 2016-07-01

Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

by Alex A Koch, James S Bagnall, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Published 2022-03-01

Spatially coordinated dynamic gene transcription in living pituitary tissue

by Karen Featherstone, Kirsty Hey, Hiroshi Momiji, Anne V McNamara, Amanda L Patist, Joanna Woodburn, David G Spiller, Helen C Christian, Alan S McNeilly, John J Mullins, Bärbel F Finkenstädt, David A Rand, Michael RH White, Julian RE Davis
Published 2016-02-01

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.

by Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng
Published 2020-04-01

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

by Stamatia Papoutsopoulou, Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert
Published 2019-09-01