The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies

by R. Frèdi Langendonk, Daniel R. Neill, Joanne L. Fothergill
Published 2021-04-01

Development of liquid culture media mimicking the conditions of sinuses and lungs in cystic fibrosis and health [version 2; peer review: 2 approved]

by Dilem Ruhluel, Daniel R Neill, Siobhan O'Brien, Joanne L Fothergill
Published 2022-11-01

Airway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation.

by Angharad E Green, Sian Pottenger, Manal S Monshi, Thomas E Barton, Marie Phelan, Daniel R Neill
Published 2023-09-01

The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract.

by Eliane Küng, William R Coward, Daniel R Neill, Hesham A Malak, Kathrin Mühlemann, Aras Kadioglu, Markus Hilty, Lucy J Hathaway
Published 2014-01-01

Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

by Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, Aras Kadioglu
Published 2021-03-01

TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung

by Rong Xu, Laura C. Jacques, Shadia Khandaker, Daan Beentjes, Miguel Leon-Rios, Xiaoqing Wei, Neil French, Daniel R. Neill, Aras Kadioglu
Published 2023-02-01

Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis

by Laura C. Jacques, Angharad E. Green, Thomas E. Barton, Murielle Baltazar, Julia Aleksandrowicz, Rong Xu, Erwan Trochu, Aras Kadioglu, Daniel R. Neill
Published 2023-02-01

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection.

by Yasir Alhamdi, Daniel R Neill, Simon T Abrams, Hesham A Malak, Reham Yahya, Richard Barrett-Jolley, Guozheng Wang, Aras Kadioglu, Cheng-Hock Toh
Published 2015-05-01

Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance

by Chowdhury M. Hasan, Sian Pottenger, Angharad E. Green, Adrienne A. Cox, Jack S. White, Trevor Jones, Craig Winstanley, Aras Kadioglu, Megan H. Wright, Daniel R. Neill, Joanne L. Fothergill
Published 2022-11-01

T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.

by Daniel R Neill, Vitor E Fernandes, Laura Wisby, Andrew R Haynes, Daniela M Ferreira, Ameera Laher, Natalie Strickland, Stephen B Gordon, Paul Denny, Aras Kadioglu, Peter W Andrew
Published 2012-01-01

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

by Laura C. Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Rong Xu, Laura Bricio-Moreno, Marie Yang, Christopher G. Dowson, Dean B. Everett, Daniel R. Neill, Aras Kadioglu
Published 2020-04-01

Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes

by Laura Bricio-Moreno, Chrispin Chaguza, Reham Yahya, Rebecca K. Shears, Jennifer E. Cornick, Karsten Hokamp, Marie Yang, Daniel R. Neill, Neil French, Jay C. D. Hinton, Dean B. Everett, Aras Kadioglu
Published 2020-12-01

The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa.

by Daniel R Neill, Gemma L Saint, Laura Bricio-Moreno, Joanne L Fothergill, Kevin W Southern, Craig Winstanley, Stephen E Christmas, Stephen E Christmas, Joseph R Slupsky, Paul S McNamara, Aras Kadioglu, Brian F Flanagan
Published 2014-01-01

Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa

by Laura Bricio-Moreno, Victoria H. Sheridan, Ian Goodhead, Stuart Armstrong, Janet K.L. Wong, Elaine M. Waters, Joscelyn Sarsby, Stavros Panagiotou, James Dunn, Adrita Chakraborty, Yongliang Fang, Karl E. Griswold, Craig Winstanley, Joanne L. Fothergill, Aras Kadioglu, Daniel R. Neill
Published 2018-07-01

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

by Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle
Published 2010-11-01

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle.

by Dilip C Badgujar, Anjali Anil, Angharad E Green, Manalee Vishnu Surve, Shilpa Madhavan, Alison Beckett, Ian A Prior, Barsa K Godsora, Sanket B Patil, Prachi Kadam More, Shruti Guha Sarkar, Andrea Mitchell, Rinti Banerjee, Prashant S Phale, Timothy J Mitchell, Daniel R Neill, Prasenjit Bhaumik, Anirban Banerjee
Published 2020-11-01