Empagliflozin and the Prevention of Heart Failure

by Douglas L. Mann, MD, Daniel P. Kelly, MD
Published 2017-08-01

The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation

by Tomoya Sakamoto, Kirill Batmanov, Shibiao Wan, Yuanjun Guo, Ling Lai, Rick B. Vega, Daniel P. Kelly
Published 2022-04-01

PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells

by Karen Tordjman, Kara N. Standley, Carlos Bernal-Mizrachi, Teresa C. Leone, Trey Coleman, Daniel P. Kelly, Clay F. Semenkovich
Published 2002-06-01

4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE

by Timothy Luongo, Lin Wang, Karthikeyani Chellappa, Melanie R. McReynolds, Daniel P. Kelly, Joshua D. Rabinowitz, Joseph A. Baur
Published 2020-06-01

Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle

by Santosh K. Maurya, Jose L. Herrera, Sanjaya K. Sahoo, Felipe C.G. Reis, Rick B. Vega, Daniel P. Kelly, Muthu Periasamy
Published 2018-09-01

Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.

by Kari T Chambers, Zhouji Chen, Peter A Crawford, Xiaorong Fu, Shawn C Burgess, Ling Lai, Teresa C Leone, Daniel P Kelly, Brian N Finck
Published 2012-01-01

A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes.

by Sharon Cresci, Janice M Huss, Amber L Beitelshees, Philip G Jones, Matt R Minton, Gerald W Dorn, Daniel P Kelly, John A Spertus, Howard L McLeod
Published 2010-09-01

PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.

by Jianru Shi, Bingbing Jiang, Yiling Qiu, Jian Guan, Mohit Jain, Xin Cao, Michael Bauer, Lihe Su, Linda C Burkly, Teresa C Leone, Daniel P Kelly, Ronglih Liao
Published 2013-01-01

A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

by Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina de Guzman Strong, Gerald W Dorn
Published 2023-11-01

Introducing JACC: Basic to Translational Science

by Douglas L. Mann, MD, Brian H. Annex, MD, Nanette H. Bishopric, MD, Thomas Force, MD, Daniel P. Kelly, MD, Peter Libby, MD, Robert Roberts, MD, Eva van Rooij, PhD, Gordon Tomaselli, MD, L. Kristin Newby, MD, MHS
Published 2016-01-01

HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

by Malay K. Sannigrahi, Pavithra Rajagopalan, Ling Lai, Xinyi Liu, Varun Sahu, Hiroshi Nakagawa, Jalal B. Jalaly, Robert M. Brody, Iain M. Morgan, Bradford E. Windle, Xiaowei Wang, Phyllis A. Gimotty, Daniel P. Kelly, Elizabeth A. White, Devraj Basu
Published 2022-09-01

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

by Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Published 2019-10-01

RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure

by Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly
Published 2023-05-01

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics

by Kelsey H. Fisher-Wellman, James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, Robert D. Stevens, Gregory R. Wagner, Rami Najjar, Mathew D. Hirschey, J. Will Thompson, David P. Olson, Daniel P. Kelly, Timothy R. Koves, Paul A. Grimsrud, Deborah M. Muoio
Published 2019-02-01

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

by Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Sihem Boudina, Michael Courtois, David F Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O Holloszy, Denis M Medeiros, Robert E Schmidt, Jeffrey E Saffitz, E Dale Abel, Clay F Semenkovich, Daniel P Kelly
Published 2005-04-01

Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism

by Payman Zamani, Elizabeth A. Proto, Neil Wilson, Hossein Fazelinia, Hua Ding, Lynn A. Spruce, Antonio Davila Jr., Thomas C. Hanff, Jeremy A. Mazurek, Stuart B. Prenner, Benoit Desjardins, Kenneth B. Margulies, Daniel P. Kelly, Zoltan Arany, Paschalis‐Thomas Doulias, John W. Elrod, Mitchell E. Allen, Shana E. McCormack, Gayatri Maria Schur, Kevin D'Aquilla, Dushyant Kumar, Deepa Thakuri, Karthik Prabhakaran, Michael C. Langham, David C. Poole, Steven H. Seeholzer, Ravinder Reddy, Harry Ischiropoulos, Julio A. Chirinos
Published 2021-08-01

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

by Coelho, Teresa, Merlini, Giampaolo, Bulawa, Christine E., Fleming, James A., Judge, Daniel P., Kelly, Jeffery W., Maurer, Mathew S., Planté-Bordeneuve, Violaine, Labaudinière, Richard, Mundayat, Rajiv, Riley, Steve, Lombardo, Ilise, Huertas, Pedro
Published 2016