Feasibility and Challenges for Sequential Treatments in ALK-Rearranged Non-Small-Cell Lung Cancer

by Mei Elsayed, Farastuk Bozorgmehr, Farastuk Bozorgmehr, Daniel Kazdal, Daniel Kazdal, Anna-Lena Volckmar, Holger Sültmann, Holger Sültmann, Jürgen R. Fischer, Mark Kriegsmann, Mark Kriegsmann, Albrecht Stenzinger, Albrecht Stenzinger, Michael Thomas, Michael Thomas, Petros Christopoulos, Petros Christopoulos
Published 2021-04-01

Expression of HMB45, MelanA and SOX10 is rare in non-small cell lung cancer

by Mark Kriegsmann, Katharina Kriegsmann, Alexander Harms, Rémi Longuespée, Christiane Zgorzelski, Jonas Leichsenring, Thomas Muley, Hauke Winter, Daniel Kazdal, Benjamin Goeppert, Arne Warth
Published 2018-09-01

Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types

by Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ourailidis, Michael Allgäuer, Michael Menzel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger
Published 2022-07-01

Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis

by Eva Romanovsky, Klaus Kluck, Iordanis Ourailidis, Michael Menzel, Susanne Beck, Markus Ball, Daniel Kazdal, Petros Christopoulos, Peter Schirmacher, Thorsten Stiewe, Albrecht Stenzinger, Jan Budczies
Published 2023-04-01

Combination of Crizotinib and Osimertinib in T790M+ EGFR-Mutant Non-Small Cell Lung Cancer with Emerging MET Amplification Post-Osimertinib Progression in a 10-Year Survivor: A Cas...

by Miriam Blasi, Daniel Kazdal, Michael Thomas, Petros Christopoulos, Mark Kriegsmann, Regine Brandt, Anna-Lena Volckmar, Martina Kirchner, Claus Peter Heußel, Albrecht Stenzinger, Jonas Kuon
Published 2021-03-01

Comprehensive Dissection of Treatment Patterns and Outcome for Patients With Metastatic Large-Cell Neuroendocrine Lung Carcinoma

by David Fisch, Farastuk Bozorgmehr, Farastuk Bozorgmehr, Daniel Kazdal, Daniel Kazdal, Jonas Kuon, Jonas Kuon, Laura V. Klotz, Laura V. Klotz, Rajiv Shah, Rajiv Shah, Florian Eichhorn, Florian Eichhorn, Mark Kriegsmann, Mark Kriegsmann, Marc A. Schneider, Marc A. Schneider, Thomas Muley, Thomas Muley, Albrecht Stenzinger, Albrecht Stenzinger, Helge Bischoff, Petros Christopoulos, Petros Christopoulos
Published 2021-07-01

De Novo Versus Secondary Metastatic EGFR-Mutated Non-Small-Cell Lung Cancer

by Farastuk Bozorgmehr, Farastuk Bozorgmehr, Daniel Kazdal, Daniel Kazdal, Inn Chung, Inn Chung, Martina Kirchner, Nikolaus Magios, Mark Kriegsmann, Mark Kriegsmann, Michael Allgäuer, Laura V. Klotz, Laura V. Klotz, Thomas Muley, Thomas Muley, Rami A. El Shafie, Jürgen R. Fischer, Martin Faehling, Albrecht Stenzinger, Albrecht Stenzinger, Michael Thomas, Michael Thomas, Petros Christopoulos, Petros Christopoulos
Published 2021-04-01

Accurate tumor purity determination is critical for the analysis of homologous recombination deficiency (HRD)

by Michael Menzel, Volker Endris, Constantin Schwab, Klaus Kluck, Olaf Neumann, Susanne Beck, Markus Ball, Christian Schaaf, Stefan Fröhling, Peter Lichtner, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger, Jan Budczies
Published 2023-09-01

Serum cytokines predict efficacy and toxicity, but are not useful for disease monitoring in lung cancer treated with PD-(L)1 inhibitors

by Hannah Schindler, Hannah Schindler, Fabienne Lusky, Fabienne Lusky, Lea Daniello, Lea Daniello, Mariam Elshiaty, Mariam Elshiaty, Lena Gaissmaier, Lena Gaissmaier, Karolina Benesova, Margarida Souto-Carneiro, Arlou Kristina Angeles, Florian Janke, Florian Eichhorn, Daniel Kazdal, Daniel Kazdal, Marc Schneider, Stephan Liersch, Sarah Klemm, Paul Schnitzler, Albrecht Stenzinger, Albrecht Stenzinger, Holger Sültmann, Holger Sültmann, Michael Thomas, Michael Thomas, Petros Christopoulos, Petros Christopoulos
Published 2022-10-01

Therapeutic and Prognostic Implications of Immune-Related Adverse Events in Advanced Non-Small-Cell Lung Cancer

by Lea Daniello, Lea Daniello, Mariam Elshiaty, Mariam Elshiaty, Farastuk Bozorgmehr, Farastuk Bozorgmehr, Jonas Kuon, Jonas Kuon, Daniel Kazdal, Daniel Kazdal, Hannah Schindler, Hannah Schindler, Rajiv Shah, Rajiv Shah, Anna-Lena Volckmar, Fabienne Lusky, Fabienne Lusky, Leonore Diekmann, Stephan Liersch, Martin Faehling, Thomas Muley, Thomas Muley, Mark Kriegsmann, Mark Kriegsmann, Karolina Benesova, Albrecht Stenzinger, Albrecht Stenzinger, Michael Thomas, Michael Thomas, Petros Christopoulos, Petros Christopoulos
Published 2021-06-01

First proficiency testing for NGS‐based and combined NGS‐ and FISH‐based detection of FGFR2 fusions in intrahepatic cholangiocarcinoma

by Olaf Neumann, Ulrich Lehmann, Stephan Bartels, Nicole Pfarr, Thomas Albrecht, Katharina Ilm, Jens Christmann, Anna‐Lena Volckmar, Hannah Goldschmid, Martina Kirchner, Michael Allgäuer, Maria Walker, Hans Kreipe, Andrea Tannapfel, Wilko Weichert, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger
Published 2023-03-01

Genomic heterogeneity at baseline is associated with T790M resistance mutations in EGFR‐mutated lung cancer treated with the first‐/second‐generation tyrosine kinase inhibitors...

by Michael Menzel, Martina Kirchner, Klaus Kluck, Markus Ball, Susanne Beck, Michael Allgäuer, Christin Assmann, Johannes Schnorbach, Anna‐Lena Volckmar, Timothy Kwang Yong Tay, Hannah Goldschmid, Daniel SW Tan, Michael Thomas, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger, Petros Christopoulos
Published 2024-03-01

Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?

by Vivienne Theobald, Ekkehard Grünig, Nicola Benjamin, Hans‐Jürgen Seyfarth, Michael Halank, Marc A. Schneider, Sarah Richtmann, Daniel Kazdal, Katrin Hinderhofer, Panagiota Xanthouli, Benjamin Egenlauf, Satenik Harutyunova, Marius M. Hoeper, Danny Jonigk, Richard Sparla, Martina U. Muckenthaler, Christina A. Eichstaedt
Published 2023-04-01

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

by Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Stefan Fröhling, Solange Peters, Barbara Seliger, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger
Published 2021-01-01

RNA-Based Detection of Gene Fusions in Formalin-Fixed and Paraffin-Embedded Solid Cancer Samples

by Martina Kirchner, Olaf Neumann, Anna-Lena Volckmar, Fabian Stögbauer, Michael Allgäuer, Daniel Kazdal, Jan Budczies, Eugen Rempel, Regine Brandt, Suranand Babu Talla, Moritz von Winterfeld, Jonas Leichsenring, Tilmann Bochtler, Alwin Krämer, Christoph Springfeld, Peter Schirmacher, Roland Penzel, Volker Endris, Albrecht Stenzinger
Published 2019-09-01

Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer

by Nikolaus Magios, Farastuk Bozorgmehr, Anna-Lena Volckmar, Daniel Kazdal, Martina Kirchner, Felix J. Herth, Claus-Peter Heussel, Florian Eichhorn, Michael Meister, Thomas Muley, Rami A. Elshafie, Jürgen R. Fischer, Martin Faehling, Mark Kriegsmann, Peter Schirmacher, Helge Bischoff, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Published 2021-03-01

Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trial

by Maria Pouyiourou, Bianca N. Kraft, Timothy Wohlfromm, Michael Stahl, Boris Kubuschok, Harald Löffler, Ulrich T. Hacker, Gerdt Hübner, Lena Weiss, Michael Bitzer, Thomas Ernst, Philipp Schütt, Thomas Hielscher, Stefan Delorme, Martina Kirchner, Daniel Kazdal, Markus Ball, Klaus Kluck, Albrecht Stenzinger, Tilmann Bochtler, Alwin Krämer
Published 2023-10-01

Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA

by Steffen Dietz, Petros Christopoulos, Zhao Yuan, Arlou Kristina Angeles, Lisa Gu, Anna-Lena Volckmar, Simon J. Ogrodnik, Florian Janke, Chiara Dalle Fratte, Tomasz Zemojtel, Marc A. Schneider, Daniel Kazdal, Volker Endris, Michael Meister, Thomas Muley, Erika Cecchin, Martin Reck, Matthias Schlesner, Michael Thomas, Albrecht Stenzinger, Holger Sültmann
Published 2020-12-01

Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients

by Michael Menzel, Stephan Ossowski, Sebastian Kral, Patrick Metzger, Peter Horak, Ralf Marienfeld, Melanie Boerries, Steffen Wolter, Markus Ball, Olaf Neumann, Sorin Armeanu-Ebinger, Christopher Schroeder, Uta Matysiak, Hannah Goldschmid, Vincent Schipperges, Axel Fürstberger, Michael Allgäuer, Timo Eberhardt, Jakob Niewöhner, Andreas Blaumeiser, Carolin Ploeger, Tobias Bernd Haack, Timothy Kwang Yong Tay, Olga Kelemen, Thomas Pauli, Martina Kirchner, Klaus Kluck, Alexander Ott, Marcus Renner, Jakob Admard, Axel Gschwind, Silke Lassmann, Hans Kestler, Falko Fend, Anna Lena Illert, Martin Werner, Peter Möller, Thomas Theodor Werner Seufferlein, Nisar Malek, Peter Schirmacher, Stefan Fröhling, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger
Published 2023-10-01