Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells.

by Joanne M Lumsden, Robert J Schwenk, Lisa E Rein, Philippe Moris, Michel Janssens, Opokua Ofori-Anyinam, Joe Cohen, Kent E Kester, D Gray Heppner, Urszula Krzych
Published 2011-01-01

High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model.

by Sheetij Dutta, JoAnn S Sullivan, Katharine K Grady, J David Haynes, Jack Komisar, Adrian H Batchelor, Lorraine Soisson, Carter L Diggs, D Gray Heppner, David E Lanar, William E Collins, John W Barnwell
Published 2009-12-01

Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.

by John N Waitumbi, Samuel B Anyona, Carol W Hunja, Carolyne M Kifude, Mark E Polhemus, Douglas S Walsh, Chris F Ockenhouse, D Gray Heppner, Amanda Leach, Marc Lievens, W Ripley Ballou, Joe D Cohen, Colin J Sutherland
Published 2009-11-01

rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/be...

by Thomas P. Monath, Patricia E. Fast, Kayvon Modjarrad, David K. Clarke, Brian K. Martin, Joan Fusco, Richard Nichols, D. Gray Heppner, Jakub K. Simon, Sheri Dubey, Sean P. Troth, Jayanthi Wolf, Vidisha Singh, Beth-Ann Coller, James S. Robertson
Published 2019-04-01

Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge.

by Angela K Talley, Sara A Healy, Olivia C Finney, Sean C Murphy, James Kublin, Carola J Salas, Susan Lundebjerg, Peter Gilbert, Wesley C Van Voorhis, John Whisler, Ruobing Wang, Chris F Ockenhouse, D Gray Heppner, Stefan H Kappe, Patrick E Duffy
Published 2014-01-01

Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine.

by Matthew B Laurens, Bourema Kouriba, Elke Bergmann-Leitner, Evelina Angov, Drissa Coulibaly, Issa Diarra, Modibo Daou, Amadou Niangaly, William C Blackwelder, Yukun Wu, Joe Cohen, W Ripley Ballou, Johan Vekemans, David E Lanar, Sheetij Dutta, Carter Diggs, Lorraine Soisson, D Gray Heppner, Ogobara K Doumbo, Christopher V Plowe, Mahamadou A Thera
Published 2017-01-01

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

by Mark E Polhemus, Shon A Remich, Bernhards R Ogutu, John N Waitumbi, Lucas Otieno, Stella Apollo, James F Cummings, Kent E Kester, Christian F Ockenhouse, Ann Stewart, Opokua Ofori-Anyinam, Isabelle Ramboer, Conor P Cahill, Marc Lievens, Marie-Claude Dubois, Marie-Ange Demoitie, Amanda Leach, Joe Cohen, W Ripley Ballou, D Gray Heppner
Published 2009-07-01

Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.

by Bernhards R Ogutu, Odika J Apollo, Denise McKinney, Willis Okoth, Joram Siangla, Filip Dubovsky, Kathryn Tucker, John N Waitumbi, Carter Diggs, Janet Wittes, Elissa Malkin, Amanda Leach, Lorraine A Soisson, Jessica B Milman, Lucas Otieno, Carolyn A Holland, Mark Polhemus, Shon A Remich, Christian F Ockenhouse, Joe Cohen, W Ripley Ballou, Samuel K Martin, Evelina Angov, V Ann Stewart, Jeffrey A Lyon, D Gray Heppner, Mark R Withers, MSP-1 Malaria Vaccine Working Group
Published 2009-01-01

Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial.

by Mahamadou A Thera, Ogobara K Doumbo, Drissa Coulibaly, Dapa A Diallo, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Alassane Dicko, Issaka Sagara, Mahamadou S Sissoko, Mounirou Baby, Mady Sissoko, Issa Diarra, Amadou Niangaly, Amagana Dolo, Modibo Daou, Sory I Diawara, D Gray Heppner, V Ann Stewart, Evelina Angov, Elke S Bergmann-Leitner, David E Lanar, Sheetij Dutta, Lorraine Soisson, Carter L Diggs, Amanda Leach, Alex Owusu, Marie-Claude Dubois, Joe Cohen, Jason N Nixon, Aric Gregson, Shannon L Takala, Kirsten E Lyke, Christopher V Plowe
Published 2008-01-01

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

by Michele D Spring, James F Cummings, Christian F Ockenhouse, Sheetij Dutta, Randall Reidler, Evelina Angov, Elke Bergmann-Leitner, V Ann Stewart, Stacey Bittner, Laure Juompan, Mark G Kortepeter, Robin Nielsen, Urszula Krzych, Ev Tierney, Lisa A Ware, Megan Dowler, Cornelus C Hermsen, Robert W Sauerwein, Sake J de Vlas, Opokua Ofori-Anyinam, David E Lanar, Jack L Williams, Kent E Kester, Kathryn Tucker, Meng Shi, Elissa Malkin, Carole Long, Carter L Diggs, Lorraine Soisson, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, D Gray Heppner
Published 2009-01-01

Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.

by Mahamadou A Thera, Ogobara K Doumbo, Drissa Coulibaly, Matthew B Laurens, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Mady Sissoko, Dapa A Diallo, Issa Diarra, Bourema Kouriba, Modibo Daou, Amagana Dolo, Mounirou Baby, Mahamadou S Sissoko, Issaka Sagara, Amadou Niangaly, Idrissa Traore, Ally Olotu, Olivier Godeaux, Amanda Leach, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, Darby Thompson, Tina Dube, Lorraine Soisson, Carter L Diggs, Shannon L Takala, Kirsten E Lyke, Brent House, David E Lanar, Sheetij Dutta, D Gray Heppner, Christopher V Plowe
Published 2010-02-01

A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2

by Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Juin-Hua Huang, Be-Shen Kuo, Feng Lin, Yaw-Jen Liu, Zhi Liu, Huang-Ting Wu, Shuang Ding, Kou-Liang Hou, Jennifer Cheng, Ya-Ting Yang, Ming-Han Jiang, Min-Sheng Wang, Tony Chen, Wei Guo Xia, Ed Lin, Chung Ho Hung, Hui-Jung Chen, Zhonghao Shih, Yi Ling Lin, Valorie Ryan, Mei Mei Hu, D. Gray Heppner, Delphine C. Malherbe, Sivakumar Periasamy, Natalia Kuzmina, Chandru Subramani, Michael Hellerstein, Thomas P. Monath, Alexander Rumyantsev, Alexander Bukreyev, Farshad Guirakhoo
Published 2022-12-01

Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial.

by Matthew B Laurens, Mahamadou A Thera, Drissa Coulibaly, Amed Ouattara, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Idrissa Traore, Bourema Kouriba, Dapa A Diallo, Issa Diarra, Modibo Daou, Amagana Dolo, Youssouf Tolo, Mahamadou S Sissoko, Amadou Niangaly, Mady Sissoko, Shannon Takala-Harrison, Kirsten E Lyke, Yukun Wu, William C Blackwelder, Olivier Godeaux, Johan Vekemans, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, Tina Dube, Lorraine Soisson, Carter L Diggs, Brent House, Jason W Bennett, David E Lanar, Sheetij Dutta, D Gray Heppner, Christopher V Plowe, Ogobara K Doumbo
Published 2013-01-01

A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants

by Chang Yi Wang, Kao-Pin Hwang, Hui-Kai Kuo, Wen-Jiun Peng, Yea-Huei Shen, Be-Sheng Kuo, Juin-Hua Huang, Hope Liu, Yu-Hsin Ho, Feng Lin, Shuang Ding, Zhi Liu, Huan-Ting Wu, Ching-Tai Huang, Yuarn-Jang Lee, Ming-Che Liu, Yi-Ching Yang, Po-Liang Lu, Hung-Chin Tsai, Chen-Hsiang Lee, Zhi-Yuan Shi, Chun-Eng Liu, Chun-Hsing Liao, Feng-Yee Chang, Hsiang-Cheng Chen, Fu-Der Wang, Kuo-Liang Hou, Jennifer Cheng, Min-Sheng Wang, Ya-Ting Yang, Han-Chen Chiu, Ming-Han Jiang, Hao-Yu Shih, Hsuan-Yu Shen, Po-Yen Chang, Yu-Rou Lan, Chi-Tian Chen, Yi-Ling Lin, Jian-Jong Liang, Chun-Che Liao, Yu-Chi Chou, Mary Kate Morris, Carl V. Hanson, Farshad Guirakhoo, Michael Hellerstein, Hui-Jing Yu, Chwan-Chuen King, Tracy Kemp, D. Gray Heppner, Thomas P. Monath
Published 2022-05-01