Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.

by Rebecca L Smathers, Kristofer S Fritz, James J Galligan, Colin T Shearn, Philip Reigan, Michael J Marks, Dennis R Petersen
Published 2012-01-01

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.

by Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Karim C El Kasmi, David J Orlicky, Ronald J Sokol
Published 2023-01-01

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition

by Colin T. Shearn, Aimee L. Anderson, Michael W. Devereaux, Karim C. El Kasmi, David J. Orlicky, Ronald J. Sokol
Published 2023-01-01

Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.

by Dennis R Petersen, Laura M Saba, Volkan I Sayin, Thales Papagiannakopoulos, Edward E Schmidt, Gary F Merrill, David J Orlicky, Colin T Shearn
Published 2018-01-01

Susceptibility of L-FABP−/− mice to oxidative stress in early-stage alcoholic liver[S]

by Rebecca L. Smathers, James J. Galligan, Colin T. Shearn, Kristofer S. Fritz, Kelly Mercer, Martin Ronis, David J. Orlicky, Nicholas O. Davidson, Dennis R. Petersen
Published 2013-05-01

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury

by Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol
Published 2023-01-01

Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.

by Colin T Shearn, Kelly E Mercer, David J Orlicky, Leah Hennings, Rebecca L Smathers-McCullough, Bangyan L Stiles, Martin J J Ronis, Dennis R Petersen
Published 2014-01-01

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

by James J. Galligan, Rebecca L. Smathers, Colin T. Shearn, Kristofer S. Fritz, Donald S. Backos, Hua Jiang, Christopher C. Franklin, David J. Orlicky, Kenneth N. MacLean, Dennis R. Petersen
Published 2012-01-01

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress

by Kusum K. Kharbanda, Martin J. J. Ronis, Colin T. Shearn, Dennis R. Petersen, Samir Zakhari, Dennis R. Warner, Ariel E. Feldstein, Craig J. McClain, Irina A. Kirpich
Published 2018-03-01

The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.

by Colin T Shearn, Aimee L Anderson, Michael W Devereux, David J Orlicky, Cole Michel, Dennis R Petersen, Colin G Miller, Sanjiv Harpavat, Edward E Schmidt, Ronald J Sokol
Published 2022-01-01

Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.

by Colin T Shearn, David J Orlicky, Rebecca L McCullough, Hua Jiang, Kenneth N Maclean, Kelly E Mercer, Bangyan L Stiles, Laura M Saba, Martin J Ronis, Dennis R Petersen
Published 2016-01-01

Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

by Colin T. Shearn, Kristofer S. Fritz, Alisabeth H. Shearn, Laura M. Saba, Kelly E. Mercer, Bridgette Engi, James J. Galligan, Piotr Zimniak, David J. Orlicky, Martin J. Ronis, Dennis R. Petersen
Published 2016-04-01

Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

by Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt
Published 2021-02-01

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

by Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt
Published 2017-06-01