Neurobiology of Huntington's Disease

by Alan H. Sharp, Christopher A. Ross
Published 1996-02-01

Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

by Wenfei Wang, Wenzhen Duan, Shuichi Igarashi, Hokuto Morita, Masayuki Nakamura, Christopher A. Ross
Published 2005-11-01

Sox11 Reduces Caspase-6 Cleavage and Activity.

by Elaine Waldron-Roby, Janine Hoerauf, Nicolas Arbez, Shanshan Zhu, Kirsten Kulcsar, Christopher A Ross
Published 2015-01-01

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

by Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross
Published 2019-09-01

Metabolic and hormonal signatures in pre-manifest and manifest Huntington’s disease patients

by Rui eWang, Christopher A Ross, Christopher A Ross, Huan eCai, Wei-na eCong, Caitlin M Daimon, Olga D Carlson, Josephine M Egan, Sana eSiddiqui, Stuart eMaudsley, Bronwen eMartin
Published 2014-06-01

cDNA Cloning and Characterization of an Atrophin-1 (DRPLA Disease Gene)-Related Protein

by Farhat A. Khan, Russell L. Margolis, Scott L. Loev, Alan H. Sharp, Shi-Hua Li, Christopher A. Ross
Published 1996-04-01

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

by Dejun Yang, Tianxia Li, Zhaohui Liu, Nicolas Arbez, Jianqun Yan, Timothy H. Moran, Christopher A. Ross, Wanli W. Smith
Published 2012-09-01

Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.

by Erin E Watkin, Nicolas Arbez, Elaine Waldron-Roby, Robert O'Meally, Tamara Ratovitski, Robert N Cole, Christopher A Ross
Published 2014-01-01

Cloning and expression of the rat atrophin-I (DRPLA disease gene) homologue

by Scott J. Loev, Russell L. Margolis, W.Scott Young, Shi-Hua Li, Gabriele Schilling, Roxann G. Ashworth, Christopher A. Ross
Published 1995-06-01

Tissue Transglutaminase Selectively Modifies Proteins Associated with Truncated Mutant Huntingtin in Intact Cells

by Wanjoo Chun, Mathieu Lesort, Janusz Tucholski, Peter W. Faber, Marcy E. MacDonald, Christopher A. Ross, Gail V.W. Johnson
Published 2001-06-01

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

by Akira Sawa, Eiichiro Nagata, Siobhan Sutcliffe, Pratima Dulloor, Matthew B. Cascio, Yuji Ozeki, Sophie Roy, Christopher A. Ross, Solomon H. Snyder
Published 2005-11-01

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

by Naoki Masuda, Qi Peng, Qing Li, Mali Jiang, Yideng Liang, Xiaofang Wang, Ming Zhao, Wenfei Wang, Christopher A. Ross, Wenzhen Duan
Published 2008-06-01

Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat Lengt...

by Mark W. Becher, Joyce A. Kotzuk, Alan H. Sharp, Stephen W. Davies, Gillian P. Bates, Donald L. Price, Christopher A. Ross
Published 1998-01-01

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

by Tianxia Li, Bo Ning, Lingbo Kong, Bingling Dai, Xiaofei He, Joseph M. Thomas, Akira Sawa, Christopher A. Ross, Wanli W. Smith
Published 2021-02-01

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

by Wenzhen Duan, Qi Peng, Naoki Masuda, Eric Ford, Erik Tryggestad, Bruce Ladenheim, Ming Zhao, Jean Lud Cadet, John Wong, Christopher A. Ross
Published 2008-06-01

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

by Haibing Jiang, Michelle A. Poirier, Yideng Liang, Zhong Pei, Charlotte E. Weiskittel, Wanli W. Smith, Donald B. DeFranco, Christopher A. Ross
Published 2006-09-01

G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans

by Simei Long, Wenyuan Guo, Sophie Hu, Fengjuan Su, Yixuan Zeng, Jinsheng Zeng, Eng-King Tan, Eng-King Tan, Eng-King Tan, Christopher A. Ross, Zhong Pei
Published 2018-11-01

Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration

by Jinru Zhang, Jinru Zhang, Kai Li, Xiaobo Wang, Xiaobo Wang, Amber M. Smith, Bo Ning, Zhaohui Liu, Chunfeng Liu, Chunfeng Liu, Christopher A. Ross, Wanli W. Smith
Published 2021-10-01

Cerebral cortex structure in prodromal Huntington disease

by Peggy C. Nopoulos, Elizabeth H. Aylward, Christopher A. Ross, Hans J. Johnson, Vincent A. Magnotta, Andrew R. Juhl, Ronald K. Pierson, James Mills, Douglas R. Langbehn, Jane S. Paulsen
Published 2010-12-01

A Mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado–Joseph disease-like transgenic mice

by Veronica F. Colomer Gould, Daniel Goti, Donna Pearce, Guillermo A. Gonzalez, Hong Gao, Mario Bermudez de Leon, Nancy A. Jenkins, Neal G. Copeland, Christopher A. Ross, Dale R. Brown
Published 2007-09-01