Chagas Disease Cardiomyopathy: Immunopathology and Genetics

by Edecio Cunha-Neto, Christophe Chevillard
Published 2014-01-01

Immunology and Infection by Protozoan Parasites

by Edecio Cunha-Neto, Christophe Chevillard, Mauricio Martins Rodrigues, Marcelo T. Bozza
Published 2015-01-01

Mitochondria as a Cellular Hub in Infection and Inflammation

by Pauline Andrieux, Christophe Chevillard, Edecio Cunha-Neto, João Paulo Silva Nunes
Published 2021-10-01

Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction

by Sandrine Cabantous, Belco Poudiougou, Aurélie Bergon, Abdoulaye Barry, Aboubacar A. Oumar, Abdoulaye M. Traore, Christophe Chevillard, Ogobara Doumbo, Alain Dessein, Sandrine Marquet
Published 2020-01-01

Prevalence of Inflammatory Pathways Over Immuno-Tolerance in Peripheral Blood Mononuclear Cells of Recent-Onset Type 1 Diabetes

by Aritania Sousa Santos, Edécio Cunha-Neto, Nelson Vinicius Gonfinetti, Fernanda Bernardi Bertonha, Pauline Brochet, Aurelie Bergon, Carlos Alberto Moreira-Filho, Christophe Chevillard, Maria Elizabeth Rossi da Silva
Published 2022-01-01

Editorial: Mitochondria at the Crossroads of Immunity and Inflammatory Tissue Damage

by João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, Pedro M. Moraes-Vieira, Christophe Chevillard, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2021-11-01

MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes.

by Isabela Cunha Navarro, Frederico Moraes Ferreira, Helder I Nakaya, Monique Andrade Baron, Gláucia Vilar-Pereira, Isabela Resende Pereira, Ana Maria Gonçalves Silva, Juliana Monte Real, Thales De Brito, Christophe Chevillard, Joseli Lannes-Vieira, Jorge Kalil, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira
Published 2015-01-01

Parasite DNA and Markers of Decreased Immune Activation Associate Prospectively with Cardiac Functional Decline over 10 Years among <i>Trypanosoma cruzi</i> Seropositive Individual...

by Ashwin Sunderraj, Luisa Marin Cunha, Matheus Avila, Shaina Alexandria, Ariela Mota Ferreira, Léa Campos de Oliveira-da Silva, Antonio L. P. Ribeiro, Maria do Carmo Pereira Nunes, Ester C. Sabino, Alan Landay, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto, Matthew J. Feinstein
Published 2023-12-01

Ebi3 Prevents Trypanosoma cruzi-Induced Myocarditis by Dampening IFN-γ-Driven Inflammation

by Tiago Silva Medina, Gabriela Gonçalves Oliveira, Maria Cláudia Silva, Bruna Araújo David, Grace Kelly Silva, Denise Morais Fonseca, Renata Sesti-Costa, Amanda Farage Frade, Amanda Farage Frade, Monique Andrade Baron, Barbara Ianni, Alexandre Costa Pereira, Christophe Chevillard, Edécio Cunha-Neto, José Antonio Marin-Neto, João Santana Silva
Published 2017-09-01

Chagas Disease Megaesophagus Patients Carrying Variant <i>MRPS18B</i> P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-γ Stimulus

by Karla Deysiree Alcântara Silva, João Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Andréia Cristina Kazue Kuramoto Takara, Natalia Bueno Pereira, Laurent Abel, Aurelie Cobat, Ricardo Costa Fernandes Zaniratto, Débora Levy, Sergio Paulo Bydlowski, Ivan Cecconello, Francisco Carlos Bernal da Costa Seguro, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto
Published 2022-09-01

miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy.

by Laurie Laugier, Ludmila Rodrigues Pinto Ferreira, Frederico Moraes Ferreira, Sandrine Cabantous, Amanda Farage Frade, Joao Paulo Nunes, Rafael Almeida Ribeiro, Pauline Brochet, Priscila Camillo Teixeira, Ronaldo Honorato Barros Santos, Edimar A Bocchi, Fernando Bacal, Darlan da Silva Cândido, Vanessa Escolano Maso, Helder I Nakaya, Jorge Kalil, Edecio Cunha-Neto, Christophe Chevillard
Published 2020-12-01

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

by Maria C. Silva, Marcela Davoli-Ferreira, Tiago S. Medina, Renata Sesti-Costa, Grace K. Silva, Carla D. Lopes, Lucas E. Cardozo, Fábio N. Gava, Konstantina Lyroni, Fabrício C. Dias, Amanda F. Frade, Monique Baron, Helder I. Nakaya, Florêncio Figueiredo, José C. Alves-Filho, Fernando Q. Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S. Silva, Thiago M. Cunha
Published 2018-04-01

Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy

by Christophe Chevillard, João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, Amanda Farage Frade, Amanda Farage Frade, Amanda Farage Frade, Rafael Ribeiro Almeida, Rafael Ribeiro Almeida, Rafael Ribeiro Almeida, Ramendra Pati Pandey, Ramendra Pati Pandey, Ramendra Pati Pandey, Marilda Savóia Nascimento, Marilda Savóia Nascimento, Marilda Savóia Nascimento, Jorge Kalil, Jorge Kalil, Jorge Kalil, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2018-12-01

Impairment of Multiple Mitochondrial Energy Metabolism Pathways in the Heart of Chagas Disease Cardiomyopathy Patients

by Priscila Camillo Teixeira, Priscila Camillo Teixeira, Axel Ducret, Hanno Langen, Everson Nogoceke, Ronaldo Honorato Barros Santos, João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, Luiz Benvenuti, Debora Levy, Sergio Paulo Bydlowski, Edimar Alcides Bocchi, Andréia Kuramoto Takara, Alfredo Inácio Fiorelli, Noedir Antonio Stolf, Pablo Pomeranzeff, Christophe Chevillard, Jorge Kalil, Jorge Kalil, Jorge Kalil, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2021-11-01

Corrigendum: Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy

by Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Barbara Maria Ianni, Sandrine Cabantous, Cristina Wide Pissetti, Bruno Saba, Hui Tzu Lin-Wang, Paula Buck, José Antonio Marin-Neto, André Schmidt, Fabrício Dias, Mario Hiroyuki Hirata, Marcelo Sampaio, Abílio Fragata, Alexandre Costa Pereira, Eduardo Donadi, Virmondes Rodrigues, Jorge Kalil, Jorge Kalil, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2020-09-01

Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy

by Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Amanda Farage Frade-Barros, Barbara Maria Ianni, Sandrine Cabantous, Cristina Wide Pissetti, Bruno Saba, Hui Tzu Lin-Wang, Paula Buck, José Antonio Marin-Neto, André Schmidt, Fabrício Dias, Mario Hiroyuki Hirata, Marcelo Sampaio, Abílio Fragata, Alexandre Costa Pereira, Eduardo Donadi, Virmondes Rodrigues, Jorge Kalil, Jorge Kalil, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2020-07-01

Polymorphism in the alpha cardiac muscle actin 1 gene is associated to susceptibility to chronic inflammatory cardiomyopathy.

by Amanda Farage Frade, Priscila Camilo Teixeira, Barbara Maria Ianni, Cristina Wide Pissetti, Bruno Saba, Lin Hui Tzu Wang, Andréia Kuramoto, Luciana Gabriel Nogueira, Paula Buck, Fabrício Dias, Helene Giniaux, Agnes Llored, Sthefanny Alves, Andre Schmidt, Eduardo Donadi, José Antonio Marin-Neto, Mario Hirata, Marcelo Sampaio, Abílio Fragata, Edimar Alcides Bocchi, Antonio Noedir Stolf, Alfredo Inacio Fiorelli, Ronaldo Honorato Barros Santos, Virmondes Rodrigues, Alexandre Costa Pereira, Jorge Kalil, Edecio Cunha-Neto, Christophe Chevillard
Published 2013-01-01

Matrix Metalloproteinase 2 and 9 Enzymatic Activities are Selectively Increased in the Myocardium of Chronic Chagas Disease Cardiomyopathy Patients: Role of TIMPs

by Monique Andrade Baron, Monique Andrade Baron, Monique Andrade Baron, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira, Priscila Camillo Teixeira, Priscila Camillo Teixeira, Priscila Camillo Teixeira, Ana Iochabel Soares Moretti, Ronaldo Honorato Barros Santos, Amanda Farage Frade, Amanda Farage Frade, Amanda Farage Frade, Andréia Kuramoto, Andréia Kuramoto, Victor Debbas, Luiz Alberto Benvenuti, Fabio Antônio Gaiotto, Fernando Bacal, Pablo Pomerantzeff, Christophe Chevillard, Jorge Kalil, Jorge Kalil, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2022-03-01

Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyo...

by João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, João Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Rafael Ribeiro Almeida, Eduardo Kitano, André Kenji Honda, Leo Kei Iwai, Débora Andrade-Silva, David Goudenège, Karla Deysiree Alcântara Silva, Karla Deysiree Alcântara Silva, Raquel de Souza Vieira, Débora Levy, Sergio Paulo Bydlowski, Frédéric Gallardo, Magali Torres, Edimar Alcides Bocchi, Miguel Mano, Ronaldo Honorato Barros Santos, Fernando Bacal, Pablo Pomerantzeff, Francisco Rafael Martins Laurindo, Priscila Camillo Teixeira, Helder I. Nakaya, Jorge Kalil, Jorge Kalil, Jorge Kalil, Vincent Procaccio, Christophe Chevillard, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto
Published 2021-11-01

Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy

by Frédéric Gallardo, Pauline Brochet, David Goudenège, João Paulo Silva Nunes, Pauline Andrieux, Barbara Maria Ianni, Amanda Farage Frade, Charles Mady, Ronaldo Honorato Barros Santos, Andreia Kuramoto, Samuel Steffen, Antonio Noedir Stolf, Pablo Pomerantzeff, Alfredo Inacio Fiorelli, Edimar Alcides Bocchi, Cristina Wide Pissetti, Bruno Saba, Fabrício C. Dias, Marcelo Ferraz Sampaio, Fabio Antônio Gaiotto, José Antonio Marin-Neto, Abílio Fragata, Ricardo Costa Fernandes Zaniratto, Sergio Siqueira, Giselle De Lima Peixoto, Fernando Bacal, Paula Buck, Rafael Ribeiro Almeida, Hui Tzu Lin-Wang, André Schmidt, Mario Hiroyuki Hirata, Eduardo Antonio Donadi, Alexandre Costa Pereira, Virmondes Rodrigues Junior, Martino Martinelli, Michel Naslavsky, Jorge Kalil, Vincent Procaccio, Edecio Cunha-Neto, Christophe Chevillard
Published 2023-12-01