SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model

by Christin Mache, Jessica Schulze, Gudrun Holland, Daniel Bourquain, Jean-Marc Gensch, Djin-Ye Oh, Andreas Nitsche, Ralf Dürrwald, Michael Laue, Thorsten Wolff
Published 2022-10-01

Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome

by Yuguang Fu, Marianne Wedde, Sigrun Smola, Djin-Ye Oh, Thorsten Pfuhl, Jürgen Rissland, Michael Zemlin, Fidelis A. Flockerzi, Rainer M. Bohle, Andrea Thürmer, Susanne Duwe, Barbara Biere, Janine Reiche, Brunhilde Schweiger, Christin Mache, Thorsten Wolff, Georg Herrler, Ralf Dürrwald
Published 2024-03-01

Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

by Simon Schroeder, Christin Mache, Hannah Kleine-Weber, Victor M. Corman, Doreen Muth, Anja Richter, Diana Fatykhova, Ziad A. Memish, Megan L. Stanifer, Steeve Boulant, Mitra Gultom, Ronald Dijkman, Stephan Eggeling, Andreas Hocke, Stefan Hippenstiel, Volker Thiel, Stefan Pöhlmann, Thorsten Wolff, Marcel A. Müller, Christian Drosten
Published 2021-09-01

Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets

by Nico Joel Halwe, Lea Hamberger, Julia Sehl-Ewert, Christin Mache, Jacob Schön, Lorenz Ulrich, Sten Calvelage, Mario Tönnies, Jonas Fuchs, Pooja Bandawane, Madhumathi Loganathan, Anass Abbad, Juan Manuel Carreño, Maria C. Bermúdez-González, Viviana Simon, Ahmed Kandeil, Rabeh El-Shesheny, Mohamed A. Ali, Ghazi Kayali, Matthias Budt, Stefan Hippenstiel, Andreas C. Hocke, Florian Krammer, Thorsten Wolff, Martin Schwemmle, Kevin Ciminski, Donata Hoffmann, Martin Beer
Published 2024-04-01

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.

by Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C Jones, Markus Morkel, Sandra Ciesek, Leif G Hanitsch, Marcus A Mall, Andreas C Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M Corman, Marcel A Müller, Christine Goffinet, Christian Drosten
Published 2022-11-01