Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

by Claudia Maletzki, Leonie Wiegele, Ingy Nassar, Jan Stenzel, Christian Junghanss
Published 2019-01-01

Cyclin-Dependent Kinase Inhibitors in Hematological Malignancies—Current Understanding, (Pre-)Clinical Application and Promising Approaches

by Anna Richter, Nina Schoenwaelder, Sina Sender, Christian Junghanss, Claudia Maletzki
Published 2021-05-01

Aortic valve and coronary artery bypass surgery in a patient with factor VII deficiency

by Larissa Henze, Christian Junghanss, Alper Öner, Pascal M Dohmen, Anthony Alozie
Published 2021-01-01

Origin of breath isoprene in humans is revealed via multi-omic investigations

by Pritam Sukul, Anna Richter, Christian Junghanss, Jochen K. Schubert, Wolfram Miekisch
Published 2023-09-01

In vivo vaccination with cell line-derived whole tumor lysates: neoantigen quality, not quantity matters

by Inken Salewski, Yvonne Saara Gladbach, Steffen Kuntoff, Nina Irmscher, Olga Hahn, Christian Junghanss, Claudia Maletzki
Published 2020-10-01

Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies

by Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, Tomas Fiedler, Christian Junghanss, Claudia Maletzki
Published 2018-11-01

Validation of an LC–MS/MS Method for the Quantification of the CK2 Inhibitor Silmitasertib (CX-4945) in Human Plasma

by Rico Schwarz, Anna Richter, Elisabeth R. D. Ito, Hugo Murua Escobar, Christian Junghanß, Burkhard Hinz
Published 2022-04-01

Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1^−/− Mice

by Yvonne Saara Gladbach, Leonie Wiegele, Mohamed Hamed, Anna-Marie Merkenschläger, Georg Fuellen, Christian Junghanss, Claudia Maletzki
Published 2019-10-01

Combined BCL-2 and PI3K/AKT Pathway Inhibition in <i>KMT2A</i>-Rearranged Acute B-Lymphoblastic Leukemia Cells

by Clemens Holz, Sandra Lange, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Hugo Murua Escobar, Christian Junghanss, Anna Richter
Published 2023-01-01

Comparative Analyses of Targeted Myeloid Cancer Next-Generation Sequencing Panel in Fresh Blood, Bone Marrow and FFPE Material

by Andrea Daniela Hobeck, Sophia Wendt, Saskia Krohn, Gudrun Knuebel, Stephan Bartels, Elisa Schipper, Christian Junghanss, Hugo Murua Escobar
Published 2024-03-01

Abdominal venous thromboses: detection of the JAK2 p.V617F mutation by next-generation ultradeep sequencing—A prevalence study of patients in Mecklenburg-West Pomerania (2017–2021)...

by Larissa Henze, Luise Grunwald, Sabine Felser, Maria Witte, Christina Grosse-Thie, Catrin Roolf, Hugo Murua Escobar, Christian Junghanss
Published 2024-01-01

Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib

by Sina Sender, Anett Sekora, Simon Villa Perez, Oleksandra Chabanovska, Annegret Becker, Anaclet Ngezahayo, Christian Junghanss, Hugo Murua Escobar
Published 2021-01-01

CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors

by Inken Salewski, Julia Henne, Leonie Engster, Paula Krone, Bjoern Schneider, Caterina Redwanz, Heiko Lemcke, Larissa Henze, Christian Junghanss, Claudia Maletzki
Published 2022-12-01

Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors

by Inken Salewski, Julia Henne, Leonie Engster, Bjoern Schneider, Heiko Lemcke, Anna Skorska, Peggy Berlin, Larissa Henze, Christian Junghanss, Claudia Maletzki
Published 2021-06-01

Basic ctDNA Panel Promises Affordable Clinical Validity in Colon Cancer Patients but Not in Pancreas Cancer Patients

by Mandy Radefeldt, Silke Stellmacher-Kaiser, Susann Krake, Brigitte Kragl, Sabrina Lemke, Christian Beetz, Peter Bauer, Christian Junghanß, Ruslan Al-Ali
Published 2023-11-01

Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors

by Paula Krone, Annabell Wolff, Julia Teichmann, Johanna Maennicke, Julia Henne, Leonie Engster, Inken Salewski, Wendy Bergmann, Christian Junghanss, Claudia Maletzki
Published 2023-12-01

Ultradeep targeted sequencing reveals low allele frequencies of somatic JAK2 and MPL variants in patients with abdominal vein thromboses: results of an ongoing prospective prevalen...

by Luise Grunwald, Christina Grosse-Thie, Sina Sender, Gudrun Knuebel, Saskia Krohn, Catrin Roolf, Christian Junghanss, Larissa Henze, Hugo Murua Escobar
Published 2020-12-01

Evaluation of combination protocols of the chemotherapeutic agent FX-9 with azacitidine, dichloroacetic acid, doxorubicin or carboplatin on prostate carcinoma cell lines.

by Franziska Weiner, Jan Torben Schille, Jens Ingo Hein, Xiao-Feng Wu, Matthias Beller, Christian Junghanß, Hugo Murua Escobar, Ingo Nolte
Published 2021-01-01

Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo

by Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf
Published 2020-03-01

Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse

by Yvonne Saara Gladbach, Lisa-Madeleine Sklarz, Catrin Roolf, Julia Beck, Ekkehard Schütz, Georg Fuellen, Christian Junghanss, Hugo Murua Escobar, Mohamed Hamed
Published 2022-07-01