Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

by Chengran Yang, Anne M. Fagan, Richard J. Perrin, Herve Rhinn, Oscar Harari, Carlos Cruchaga
Published 2022-12-01

Implementing quantum dimensionality reduction for non-Markovian stochastic simulation

by Kang-Da Wu, Chengran Yang, Ren-Dong He, Mile Gu, Guo-Yong Xiang, Chuan-Feng Li, Guang-Can Guo, Thomas J. Elliott
Published 2023-05-01

TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma

by Heng Yi, Qijun Yang, Charlie Repaci, Cheolmin Matthew Lee, Gyujin Heo, Jigyasha Timsina, Priyanka Gorijala, Chengran Yang, John Budde, Lihua Wang, Carlos Cruchaga, Yun Ju Sung
Published 2024-04-01

White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology

by Kantiya Jindachomthong, Chengran Yang, Yuegao Huang, Daniel Coman, Maximiliano Rapanelli, Fahmeed Hyder, Fahmeed Hyder, Joseph Dougherty, Luciana Frick, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger, Christopher Pittenger
Published 2022-11-01

Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials

by Stephanie J. Loomis, Nilanjana Sadhu, Elizabeth Fisher, Arie R. Gafson, Yunfeng Huang, Chengran Yang, Emily E. Hughes, Eric Marshall, Ann Herman, Sally John, Heiko Runz, Xiaoming Jia, Tushar Bhangale, Paola G. Bronson
Published 2023-08-01

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

by Laura Ibanez, Jorge A. Bahena, Chengran Yang, Umber Dube, Fabiana H. G. Farias, John P. Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin, Nigel J. Cairns, John O’Donnell, Ignacio Álvarez, Monica Diez-Fairen, Miquel Aguilar, Rebecca Miller, Albert A. Davis, Pau Pastor, Paul Kotzbauer, Meghan C. Campbell, Joel S. Perlmutter, Herve Rhinn, Oscar Harari, Carlos Cruchaga, Bruno A. Benitez
Published 2020-11-01

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

by Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga
Published 2023-07-01

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease

by Lihua Wang, Niko-Petteri Nykänen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Mercè Boada, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Agustín Ruiz, Raquel Puerta, Adelina Orellana, Jarod Rutledge, Hamilton Oh, Michael D Greicius, Yann Le Guen, Richard J. Perrin, Tony Wyss-Coray, Angela Jefferson, Timothy J. Hohman, Neill Graff-Radford, Hiroshi Mori, Alison Goate, Johannes Levin, Yun Ju Sung, Carlos Cruchaga
Published 2024-01-01