IL-27-containing exosomes secreted by innate B-1a cells suppress and ameliorate uveitis

by Minkyung Kang, Manoj Kumar Yadav, Evaristus C. Mbanefo, Cheng-Rong Yu, Charles E. Egwuagu
Published 2023-06-01

Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis.

by Cheng-Rong Yu, Yun Sang Lee, Rashid M Mahdi, Narayanan Surendran, Charles E Egwuagu
Published 2012-01-01

Deletion of <i>Irf4</i> in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4⁺ T Cell Differentiation and Metabolism

by Minkyung Kang, Hyun-Su Lee, Jin Kyeong Choi, Cheng-Rong Yu, Charles E. Egwuagu
Published 2021-03-01

Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege

by Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E. Egwuagu
Published 2022-07-01

STAT3 Regulates Proliferation and Survival of CD8+ T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10+ Regulatory CD8+ T Cells in Autoimmune Uveitis

by Cheng-Rong Yu, Ivy M. Dambuza, Yong-Jun Lee, Gregory M. Frank, Charles E. Egwuagu
Published 2013-01-01

SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis)

by Chang He, Cheng-Rong Yu, Mary J. Mattapallil, Lin Sun, Joseph Larkin III, Charles E. Egwuagu
Published 2016-01-01

Interleukin 27 induces the expression of complement factor H (CFH) in the retina.

by Ahjoku Amadi-Obi, Cheng-Rong Yu, Ivy Dambuza, Sung-Hye Kim, Bernadette Marrero, Charles E Egwuagu
Published 2012-01-01

A Camelid-Derived STAT-Specific Nanobody Inhibits Neuroinflammation and Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)

by Evaristus C. Mbanefo, Allison Seifert, Manoj Kumar Yadav, Cheng-Rong Yu, Vijayaraj Nagarajan, Ashutosh Parihar, Sunanda Singh, Charles E. Egwuagu
Published 2024-06-01

STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice

by Evaristus C. Mbanefo, Ming Yan, Minkyung Kang, Sahar A. Alhakeem, Yingyos Jittayasothorn, Cheng-Rong Yu, Ashutosh Parihar, Sunanda Singh, Charles E. Egwuagu
Published 2021-09-01

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

by Ivy M. Dambuza, Chang He, Jin Kyeong Choi, Cheng-Rong Yu, Renxi Wang, Mary J. Mattapallil, Paul T. Wingfield, Rachel R. Caspi, Charles E. Egwuagu
Published 2017-09-01

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.

by Lin Sun, Anthony J St Leger, Cheng-Rong Yu, Chang He, Rashid M Mahdi, Chi-Chao Chan, Hongsheng Wang, Herbert C Morse, Charles E Egwuagu
Published 2016-01-01

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

by Jin Kyeong Choi, Ivy M. Dambuza, Chang He, Chang He, Cheng-Rong Yu, Anita N. Uche, Mary J. Mattapallil, Rachel R. Caspi, Charles E. Egwuagu
Published 2017-10-01

Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.

by Daniel Ardeljan, Yujuan Wang, Stanley Park, Defen Shen, Xi Kathy Chu, Cheng-Rong Yu, Mones Abu-Asab, Jingsheng Tuo, Charles G Eberhart, Timothy W Olsen, Robert F Mullins, Gary White, Sam Wadsworth, Abraham Scaria, Chi-Chao Chan
Published 2014-01-01