Prediction of early clinical response in patients receiving tofacitinib in the OCTAVE Induction 1 and 2 studies

by Charlie W. Lees, J. Jasper Deuring, Michael Chiorean, Marco Daperno, Gianluca Bonfanti, Rebecca Germino, Pritha Bhadra Brown, Irene Modesto, Roger A. Edwards
Published 2021-11-01

The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing.

by Nicholas A Kennedy, Alan W Walker, Susan H Berry, Sylvia H Duncan, Freda M Farquarson, Petra Louis, John M Thomson, UK IBD Genetics Consortium, Jack Satsangi, Harry J Flint, Julian Parkhill, Charlie W Lees, Georgina L Hold
Published 2014-01-01

Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.

by Charlie W Lees, William J Zacharias, Mark Tremelling, Colin L Noble, Elaine R Nimmo, Albert Tenesa, Jennine Cornelius, Leif Torkvist, John Kao, Susan Farrington, Hazel E Drummond, Gwo-Tzer Ho, Ian D R Arnott, Henry D Appelman, Lauri Diehl, Harry Campbell, Malcolm G Dunlop, Miles Parkes, Sarah E M Howie, Deborah L Gumucio, Jack Satsangi
Published 2008-12-01

The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patientsResearch in cont...

by James L. Alexander, Benjamin H. Mullish, Nathan P. Danckert, Zhigang Liu, Marton L. Olbei, Aamir Saifuddin, Melissa Torkizadeh, Hajir Ibraheim, Jesús Miguéns Blanco, Lauren A. Roberts, Claire M. Bewshea, Rachel Nice, Simeng Lin, Hemanth Prabhudev, Caroline Sands, Verena Horneffer-van der Sluis, Matthew Lewis, Shaji Sebastian, Charlie W. Lees, Julian P. Teare, Ailsa Hart, James R. Goodhand, Nicholas A. Kennedy, Tamas Korcsmaros, Julian R. Marchesi, Tariq Ahmad, Nick Powell
Published 2023-02-01

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

by Simeng Lin, Nicholas A. Kennedy, Aamir Saifuddin, Diana Muñoz Sandoval, Catherine J. Reynolds, Rocio Castro Seoane, Sherine H. Kottoor, Franziska P. Pieper, Kai-Min Lin, David K. Butler, Neil Chanchlani, Rachel Nice, Desmond Chee, Claire Bewshea, Malik Janjua, Timothy J. McDonald, Shaji Sebastian, James L. Alexander, Laura Constable, James C. Lee, Charles D. Murray, Ailsa L. Hart, Peter M. Irving, Gareth-Rhys Jones, Klaartje B. Kok, Christopher A. Lamb, Charlie W. Lees, Daniel M. Altmann, Rosemary J. Boyton, James R. Goodhand, Nick Powell, Tariq Ahmad, CLARITY IBD study
Published 2022-03-01

A comprehensive high cost drugs dataset from the NHS in England - An OpenSAFELY-TPP Short Data Report [version 1; peer review: 3 approved]

by James Galloway, Richard Croker, Tom Ward, Nicholas A Kennedy, Anna Schultze, David Evans, Katie Bechman, Frank Hester, Kathryn E Mansfield, John Parry, Mark Yates, Julian Matthewman, Sam Harper, Sam Norton, Liam Smeeth, Jeremy Brown, Caroline E. Morton, Alex J. Walker, Elizabeth Williamson, Christopher T. Rentsch, Amelia Green, George Hickman, Helen J Curtis, Louis Fisher, Helen I. McDonald, Rosalind M. Eggo, Ian J Douglas, Angel YS Wong, Charlie W Lees, Laurie A Tomlinson, Catherine Smith, Stephen Evans, Amir Mehkar, Sinéad M. Langan, Brian MacKenna, Krishnan Bhaskaran, John Tazare, Chris Bates, Peter Inglesby, Ben Goldacre, Jonathan Cockburn, Seb Bacon, Rohini Mathur, William Hulme, Harriet Forbes, Simon Davy, Anna Rowan
Published 2021-12-01

Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multice...

by Peter M Irving, Miles Parkes, Ruth Wood, Ailsa L Hart, Nicholas A Kennedy, Nick Powell, Julian R Marchesi, Tariq Ahmad, Tim Raine, Andrew King, James O Lindsay, Kevin Whelan, Charlie W Lees, Christopher A Lamb, Jack Satsangi, Emma Clark, Shriya Sharma, Xinyue Zhang, Christopher J Stewart, Naomi McGregor, Helen C Hancock, Rebecca H Maier, John C Mansfield, Mary Doona, Michelle Bardgett, Natalie J Prescott, Trevor Liddle, Robert Lees, Hannah Watson, Carl A Anderson, Ally Speight, Ciara Kennedy, Sarah Lawrence, Nicola J Wyatt, Jennifer A Doyle, Rebecca E McIntyre, Luke Jostins-Dean, Victoria Hildreth, James MS Wason, Dean Allerton, Dawn Clewes, Cristina Cotobal Martin, Katherine Frith, Sameena Iqbal, Laura Letchford, Jasmin Ostermayer, Tolulope Osunnuyi, Tara Shrestha, Michelle Strickland, Gregory R Young
Published 2024-04-01

Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Dise...

by Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Holly Ennis, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik
Published 2023-01-01