Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS)

by Vasileia Tsintari, Bianca Walter, Falko Fend, Mathis Overkamp, Christian Rothermundt, Charles D. Lopez, Marcus M. Schittenhelm, Kerstin M. Kampa-Schittenhelm
Published 2022-07-01

Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure.

by Marcus M Schittenhelm, Barbara Illing, Figen Ahmut, Katharina Henriette Rasp, Gunnar Blumenstock, Konstanze Döhner, Charles D Lopez, Kerstin M Kampa-Schittenhelm
Published 2013-01-01

ASPP2κ Is Expressed In Human Colorectal Carcinoma And Promotes Chemotherapy Resistance And Tumorigenesis

by Ingmar Rieger, Vasileia Tsintari, Mathis Overkamp, Falko Fend, Charles D. Lopez, Marcus M. Schittenhelm, Kerstin M. Kampa-Schittenhelm, Kerstin M. Kampa-Schittenhelm
Published 2021-11-01

Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer

by Michael Overman, Richard E Davis, Pankaj Vats, Chandan Kumar-Sinha, Niharika B Mettu, Charles D Lopez, Veerendra Munugalavadla, Priti Patel, Lin Tao, Sattva Neelapu
Published 2020-06-01

Therapy Resistant Gastroenteropancreatic Neuroendocrine Tumors

by Kristen McClellan, Emerson Y. Chen, Adel Kardosh, Charles D. Lopez, Jaydira Del Rivero, Nadine Mallak, Flavio G. Rocha, Yilun Koethe, Rodney Pommier, Erik Mittra, Guillaume J. Pegna
Published 2022-09-01

Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first‐line platinum‐based chemotherapy: Phase 2 study results

by Fortunato Ciardiello, Yung‐Jue Bang, Andrés Cervantes, Mikhail Dvorkin, Charles D. Lopez, Jean‐Philippe Metges, Antonio Sánchez Ruiz, Mariona Calvo, Andrew H. Strickland, George Kannourakis, Kei Muro, Hisato Kawakami, Jia Wei, Christophe Borg, Zhaoyin Zhu, Neal Gupta, Robert J. Pelham, Lin Shen
Published 2023-06-01

Implementing a comprehensive translational oncology platform: from molecular testing to actionability

by Zahi I. Mitri, Swapnil Parmar, Brett Johnson, Annette Kolodzie, Jamie M. Keck, Max Morris, Alexander R. Guimaraes, Brooke R. Beckett, Uma Borate, Charles D. Lopez, Kathleen A. Kemmer, Joshi J. Alumkal, Tomasz M. Beer, Christopher L. Corless, Gordon B. Mills, Joe W. Gray, Raymond C. Bergan
Published 2018-12-01

Phase 2 study of preoperative chemotherapy with nab‐paclitaxel and gemcitabine followed by chemoradiation for borderline resectable or node‐positive pancreatic ductal adenocarcinom...

by Emerson Y. Chen, Adel Kardosh, Nima Nabavizadeh, Bryan Foster, Skye C. Mayo, Kevin G. Billingsley, Erin W. Gilbert, Christian Lanciault, Aaron Grossberg, Kenneth G. Bensch, Erin Maynard, Eric C. Anderson, Brett C. Sheppard, Charles R. Thomas Jr, Charles D. Lopez, Gina M. Vaccaro, OHSU Gastrointestinal Cancer Disease Group
Published 2023-06-01

Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future DirectionsSummary

by Luai R. Zarour, Sudarshan Anand, Kevin G. Billingsley, William H. Bisson, Andrea Cercek, Michael F. Clarke, Lisa M. Coussens, Charles E. Gast, Cristina B. Geltzeiler, Lissi Hansen, Katherine A. Kelley, Charles D. Lopez, Shushan R. Rana, Rebecca Ruhl, V. Liana Tsikitis, Gina M. Vaccaro, Melissa H. Wong, Skye C. Mayo
Published 2017-03-01

Neoadjuvant Therapy Is Associated with Improved Chemotherapy Delivery and Overall Survival Compared to Upfront Resection in Pancreatic Cancer without Increasing Perioperative Compl...

by Christopher Ryan Deig, Thomas Lee Sutton, Blake Beneville, Kristin Trone, Amanda Stratton, Ali N. Gunesch, Amy Ivy Liu, Alaaeddin Alrohaibani, Maedeh Mohebnasab, Solange Bassale, Alison Grossblatt-Wait, Dove Keith, Fouad Attia, Erin W. Gilbert, Charles D. Lopez, Adel Kardosh, Emerson Y. Chen, Kenneth G. Bensch, Nima Nabavizadeh, Charles R. Thomas, Skye C. Mayo, Brett C. Sheppard, Aaron Grossberg
Published 2022-01-01

Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

by Matthew S. Dietz, Thomas L. Sutton, Brett S. Walker, Charles E. Gast, Luai Zarour, Sidharth K. Sengupta, John R. Swain, Jennifer Eng, Michael Parappilly, Kristen Limbach, Ariana Sattler, Erik Burlingame, Yuki Chin, Austin Gower, Jose L. Montoya Mira, Ajay Sapre, Yu-Jui Chiu, Daniel R. Clayburgh, SuEllen J. Pommier, Jeremy P. Cetnar, Jared M. Fischer, Jerry J. Jaboin, Rodney F. Pommier, Brett C. Sheppard, V. Liana Tsikitis, Alison H. Skalet, Skye C. Mayo, Charles D. Lopez, Joe W. Gray, Gordon B. Mills, Zahi Mitri, Young Hwan Chang, Koei Chin, Melissa H. Wong
Published 2021-07-01