The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding

by Hendriks, G., Derr, R.S., Misovic, B., Morolli, B., Calleja, F.M.G.R., Vrieling, H.
Published 2016

An Efficient Pipeline for the Generation and Functional Analysis of Human BRCA2 Variants of Uncertain Significance

by Hendriks, G., Morolli, B., Calleja, F.M.G.R., Plomp, A., Mesman, R.L.S., Meijers, M., Sharan, S.K., Vreeswijk, M.P.G., Vrieling, H.
Published 2014

The functional impact of variants of uncertain significance in BRCA2

by Mesman, R.L.S., Calleja, F.M.G.R., Hendriks, G., Morolli, B., Misovic, B., Devilee, P., Asperen, C.J. van, Vrieling, H., Vreeswijk, M.P.G.
Published 2019

Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines

by Karlsson, H.L., Gliga, A.R., Calleja, F.M.G.R., Goncalves, C.S.A.G., Wallinder, I.O., Vrieling, H., Fadeel, B., Hendriks, G.
Published 2014

Correction: alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2

by Mesman, R.L.S., Calleja, F.M.G.R., Hoya, M. de la, Devilee, P., Asperen, C.J. van, Vrieling, H., Vreeswijk, M.P.G.
Published 2020

The extended ToxTracker assay discriminates between induction of DNA damage, oxidative stress and protein misfolding

by Hendriks, G., Derr, R.S., Misovic, B., Morolli, B., Calleja, F.M.G.R., Vrieling, H.
Published 2015

Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2

by Mesman, R.L.S., Calleja, F.M.G.R., Hoya, M. de la, Devilee, P., Asperen, C.J. van, Vrieling, H., Vreeswijk, M.P.G.
Published 2020

Skipping Nonsense to Maintain Function: The Paradigm of BRCA2 Exon 12

by Meulemans, L., Mesman, R.L.S., Caputo, S.M., Krieger, S., Guillaud-Bataille, M., Caux-Moncoutier, V., Leone, M., Boutry-Kryza, N., Sokolowska, J., Revillion, F., Delnatte, C., Tubeuf, H., Soukarieh, O., Bonnet-Dorion, F., Guibert, V., Bronner, M., Bourdon, V., Lizard, S., Vilquin, P., Privat, M., Drouet, A., Grout, C., Calleja, F.M.G.R., Golmard, L., Vrieling, H., Stoppa-Lyonnet, D., Houdayer, C., Frebourg, T., Vreeswijk, M.P.G., Martins, A., Gaildrat, P.
Published 2020

BRCA2 hypomorphic missense variants confer moderate risks of breast cancer

by Shimelis H., Mesman R.L.S., Von Nicolai C., Ehlen A., Guidugli L., Martin C., Calléja F.M.G.R., Meeks H., Hallberg E., Hinton J., Lilyquist J., Shu X.-O., Slager S., Southey M.C., Stram D.O., Swerdlow A., Teo S.H., Tomlinson I., Torres D., Truong T., Van Asperen C.J., Hu C., Van Der Kolk L.E., Wang Q., Winqvist R., Wu A.H., Yu J.-C., Zheng W., Zheng Y., Leary J., Walker L., Foretova L., Aalfs C.M., Fostira F., Claes K.B.M., Varesco L., Moghadasi S., Easton D.F., Spurdle A., Devilee P., Vrieling H., Monteiro A.N.A., Goldgar D.E., Aittomäki K., Carreira A., Vreeswijk M.P.G., Couch F.J., Andrulis I., Anton-Culver H., Arndt V., Beckmann M.W., Benitez J., Bogdanova N.V., Bojesen S.E., Bolla M.K., Borresen-Dale A.-L., Brauch H., Brennan P., Brenner H., Broeks A., Brouwers B., Brüning T., Burwinkel B., Chang-Claude J., Chenevix-Trench G., Cheng C.-Y., Choi J.-Y., Collée J.M., Cox A., Cross S.S., Czene K., Darabi H., Dennis J., Dörk T., Dos-Santos-Silva I., Dunning A.M., Fasching P.A., Figueroa J., Flyger H., García-Closas M., Giles G.G., Glendon G., Guénel P., Haiman C.A., Hall P., Hamann U., Hartman M., Hogervorst F.B., Hollestelle A., Hopper J.L., Ito H., Jakubowska A., Kang D., Kosma V.-M., Kristensen V., Lai K.-N., Lambrechts D., Le Marchand L., Li J., Lindblom A., Lophatananon A., Lubinski J., Machackova E., Mannermaa A., Margolin S., Marme F., Matsuo K., Miao H., Michailidou K., Milne R.L., Muir K., Neuhausen S.L., Nevanlinna H., Olson J.E., Olswold C., Oosterwijk J.J.C., Osorio A., Peterlongo P., Peto J., Pharoah P.D.P., Pylkäs K., Radice P., Rashid M.U., Rhenius V., Rudolph A., Sangrajrang S., Sawyer E.J., Schmidt M.K., Schoemaker M.J., Seynaeve C., Shah M., Shen C.-Y., Shrubsole M.
Published 2018

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

by Shimelis, H., Mesman, R.L.S., Nicolai, C. von, Ehlen, A., Guidugli, L., Martin, C., Calleja, F.M.G.R., Meeks, H., Hallberg, E., Hinton, J., Lilyquist, J., Hu, C.L., Aalfs, C.M., Aittomaki, K., Andrulis, I., Anton-Culver, H., Arndt, V., Beckmann, M.W., Benitez, J., Bogdanova, N.V., Bojesen, S.E., Bolla, M.K., Borresen-Dale, A.L., Brauch, H., Brennan, P., Brenner, H., Broeks, A., Brouwers, B., Bruning, T., Burwinkel, B., Chang-Claude, J., Chenevix-Trench, G., Cheng, C.Y., Choi, J.Y., Collee, J.M., Cox, A., Cross, S.S., Czene, K., Darabi, H., Dennis, J., Dork, T., Dos-Santos-Silva, I., Dunning, A.M., Fasching, P.A., Figueroa, J., Flyger, H., Garcia-Closas, M., Giles, G.G., Glendon, G., Guenel, P., Haiman, C.A., Hall, P., Hamann, U., Hartman, M., Hogervorst, F.B., Hollestelle, A., Hopper, J.L., Ito, H., Jakubowska, A., Kang, D., Kosma, V.M., Kristensen, V., Lai, K.N., Lambrechts, D., Marchand, L. le, Li, J.M., Lindblom, A., Lophatananon, A., Lubinski, J., Machackova, E., Mannermaa, A., Margolin, S., Marme, F., Matsuo, K., Miao, H., Michailidou, K., Milne, R.L., Muir, K., Neuhausen, S.L., Nevanlinna, H., Olson, J.E., Olswold, C., Oosterwijk, J.J.C., Osorio, A., Peterlongo, P., Peto, J., Pharoah, P.D.P., Pylkas, K., Radice, P., Rashid, M.U., Rhenius, V., Rudolph, A., Sangrajrang, S., Sawyer, E.J., Schmidt, M.K., Schoemaker, M.J., Seynaeve, C., Shah, M., Shen, C.Y., Shrubsole, M., Shu, X.O., Slager, S., Southey, M.C., Stram, D.O., Swerdlow, A., Teo, S.H., Tomlinson, I., Torres, D., Truong, T., Asperen, C.J. van, Kolk, L.E. van der, Wang, Q., Winqvist, R., Wu, A.H., Yu, J.C., Zheng, W., Zheng, Y., Leary, J., Walker, L., Foretova, L., Fostira, F., Claes, K.B.M., Varesco, L., Moghadasi, S., Easton, D.F., Spurdle, A., Devilee, P., Vrieling, H., Monteiro, A.N.A., Goldgar, D.E., Carreira, A., Vreeswijk, M.P.G., Couch, F.J., KConFab AOCS Investigators, NBCS Collaborators
Published 2017

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

by Shimelis, H., Mesman, R.L.S., Nicolai, C. von, Ehlen, A., Guidugli, L., Martin, C., Calleja, F.M.G.R., Meeks, H., Hallberg, E., Hinton, J., Lilyquist, J., Hu, C.L., Aalfs, C.M., Aittomaki, K., Andrulis, I., Anton-Culver, H., Arndt, V., Beckmann, M.W., Benitez, J., Bogdanova, N.V., Bojesen, S.E., Bolla, M.K., Borresen-Dale, A.L., Brauch, H., Brennan, P., Brenner, H., Broeks, A., Brouwers, B., Bruning, T., Burwinkel, B., Chang-Claude, J., Chenevix-Trench, G., Cheng, C.Y., Choi, J.Y., Collee, J.M., Cox, A., Cross, S.S., Czene, K., Darabi, H., Dennis, J., Dork, T., Dos-Santos-Silva, I., Dunning, A.M., Fasching, P.A., Figueroa, J., Flyger, H., Garcia-Closas, M., Giles, G.G., Glendon, G., Guenel, P., Haiman, C.A., Hall, P., Hamann, U., Hartman, M., Hogervorst, F.B., Hollestelle, A., Hopper, J.L., Ito, H., Jakubowska, A., Kang, D., Kosma, V.M., Kristensen, V., Lai, K.N., Lambrechts, D., Marchand, L. le, Li, J.M., Lindblom, A., Lophatananon, A., Lubinski, J., Machackova, E., Mannermaa, A., Margolin, S., Marme, F., Matsuo, K., Miao, H., Michailidou, K., Milne, R.L., Muir, K., Neuhausen, S.L., Nevanlinna, H., Olson, J.E., Olswold, C., Oosterwijk, J.J.C., Osorio, A., Peterlongo, P., Peto, J., Pharoah, P.D.P., Pylkas, K., Radice, P., Rashid, M.U., Rhenius, V., Rudolph, A., Sangrajrang, S., Sawyer, E.J., Schmidt, M.K., Schoemaker, M.J., Seynaeve, C., Shah, M., Shen, C.Y., Shrubsole, M., Shu, X.O., Slager, S., Southey, M.C., Stram, D.O., Swerdlow, A., Teo, S.H., Tomlinson, I., Torres, D., Truong, T., Asperen, C.J. van, Kolk, L.E. van der, Wang, Q., Winqvist, R., Wu, A.H., Yu, J.C., Zheng, W., Zheng, Y., Leary, J., Walker, L., Foretova, L., Fostira, F., Claes, K.B.M., Varesco, L., Moghadasi, S., Easton, D.F., Spurdle, A., Devilee, P., Vrieling, H., Monteiro, A.N.A., Goldgar, D.E., Carreira, A., Vreeswijk, M.P.G., Couch, F.J., KConFab AOCS Investigators, NBCS Collaborators
Published 2017