Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

by Husvinee Sundaramurthi, Zoltán Giricz, Breandán N. Kennedy
Published 2022-08-01

The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration

by Andrea Cerquone Perpetuini, Justine Mathoux, Breandán N Kennedy
Published 2019-01-01

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish [version 2; peer review: 2 approved]

by Alicia Gómez Sánchez, Basilio Colligris, Yolanda Álvarez, Breandán N. Kennedy
Published 2022-01-01

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

by Nils Ohnesorge, Temitope Sasore, Daniel Hillary, Yolanda Alvarez, Michelle Carey, Breandán N. Kennedy
Published 2019-05-01

Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration

by Stephen P. Carter, Stephen P. Carter, Ailís L. Moran, Ailís L. Moran, David Matallanas, Gavin J. McManus, Oliver E. Blacque, Oliver E. Blacque, Breandán N. Kennedy, Breandán N. Kennedy
Published 2020-03-01

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

by Rebecca Ward, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy
Published 2018-04-01

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

by Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Ailis Moran, Eugene T. Dillion, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy, Breandán N. Kennedy
Published 2020-08-01

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

by Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Published 2023-03-01

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis [version 2; peer review: 2 app...

by Alicia Gómez Sánchez, Ailis Moran, Patrizia Colucci, Basilio Colligris, Breandán N. Kennedy, Alexandro Moya López, Yolanda Álvarez
Published 2023-11-01

The Role of Mitochondria in Optic Atrophy With Autosomal Inheritance

by Elin L. Strachan, Elin L. Strachan, Delphi Mac White-Begg, Delphi Mac White-Begg, John Crean, John Crean, John Crean, Alison L. Reynolds, Alison L. Reynolds, Breandán N. Kennedy, Breandán N. Kennedy, Niamh C. O’Sullivan, Niamh C. O’Sullivan
Published 2021-11-01

Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer

by Lorraine Burke, Lorraine Burke, Clare T. Butler, Adrian Murphy, Bruce Moran, William M Gallagher, Jacintha O'Sullivan, Breandán N. Kennedy
Published 2016-09-01

Selective inhibition of retinal angiogenesis by targeting PI3 kinase.

by Yolanda Alvarez, Olaya Astudillo, Lasse Jensen, Alison L Reynolds, Nora Waghorne, Derek P Brazil, Yihai Cao, John J O'Connor, Breandán N Kennedy
Published 2009-11-01

Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells

by Amy M. Buckley, Becky AS. Bibby, Margaret R. Dunne, Susan A. Kennedy, Maria B. Davern, Breandán N. Kennedy, Stephen G. Maher, Jacintha O’Sullivan
Published 2019-02-01

Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4

by Ismael Obaidi, Hilary Cassidy, Verónica Ibáñez Gaspar, Jasmin McCaul, Michael Higgins, Melinda Halász, Alison L. Reynolds, Breandan N. Kennedy, Tara McMorrow
Published 2020-05-01

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

by Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto, Kayleigh Slater, Simone Marcone, Josep M. Piulats, Ronald William Watson, Desmond J. Tobin, Lasse D. Jensen, Breandán N. Kennedy
Published 2022-02-01

Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

by Jyothi S Akella, Stephen P Carter, Ken Nguyen, Sofia Tsiropoulou, Ailis L Moran, Malan Silva, Fatima Rizvi, Breandan N Kennedy, David H Hall, Maureen M Barr, Oliver E Blacque
Published 2020-02-01

1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model

by Kayleigh Slater, Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Kaelin Francis Smith, Chowdhury Arif Jahangir, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Sandra Garcia-Mulero, Arman Rahman, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, William M. Gallagher, Alberto Villanueva, Alberto Villanueva, Breandán N. Kennedy, Breandán N. Kennedy
Published 2023-01-01

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysisResearch in context

by Sarah M. Wade, Nils Ohnesorge, Hayley McLoughlin, Monika Biniecka, Steven P. Carter, Michelle Trenkman, Clare C. Cunningham, Trudy McGarry, Mary Canavan, Breandán N. Kennedy, Douglas J. Veale, Ursula Fearon
Published 2019-09-01

Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.

by Victor L Jensen, Stephen Carter, Anna A W M Sanders, Chunmei Li, Julie Kennedy, Tiffany A Timbers, Jerry Cai, Noemie Scheidel, Breandán N Kennedy, Ryan D Morin, Michel R Leroux, Oliver E Blacque
Published 2016-12-01

Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

by Susan A. Kennedy, Maria E. Morrissey, Margaret R. Dunne, Fiona O’Connell, Clare T. Butler, Mary-Clare Cathcart, Amy M. Buckley, Brian J. Mehigan, John O. Larkin, Paul McCormick, Breandán N. Kennedy, Jacintha O’Sullivan
Published 2020-10-01