Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

by Mark Zaidi, Mark Zaidi, Fred Fu, Dan Cojocari, Trevor D. McKee, Bradly G. Wouters, Bradly G. Wouters
Published 2019-12-01

A simple but highly effective approach to evaluate the prognostic performance of gene expression signatures.

by Maud H W Starmans, Glenn Fung, Harald Steck, Bradly G Wouters, Philippe Lambin
Published 2011-01-01

De Novo Design and Development of a Nutrient-Rich Perfusate for Ex Vivo Lung Perfusion with Cell Culture Models

by Lei Huang, Ravi N. Vellanki, Zhiyuan Zhu, Bradly G. Wouters, Shaf Keshavjee, Mingyao Liu
Published 2023-08-01

Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas

by Arjen H. G. Cleven, Manon van Engeland, Bradly G. Wouters, Adriaan P. de Bruïne
Published 2007-01-01

Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

by Roland K Chiu, Jan Brun, Chantal Ramaekers, Jan Theys, Lin Weng, Philippe Lambin, Douglas A Gray, Bradly G Wouters
Published 2006-07-01

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

by Chantal H M A Ramaekers, Twan van den Beucken, Robert G Bristow, Roland K Chiu, Daniel Durocher, Bradly G Wouters
Published 2014-01-01

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumor...

by Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill, Michael Milosevic
Published 2017-06-01

MATE2 Expression Is Associated with Cancer Cell Response to Metformin.

by Sanjana Chowdhury, Eric Yung, Melania Pintilie, Hala Muaddi, Selim Chaib, ManTek Yeung, Manlio Fusciello, Jenna Sykes, Bethany Pitcher, Anna Hagenkort, Trevor McKee, Ravi Vellanki, Eric Chen, Robert G Bristow, Bradly G Wouters, Marianne Koritzinsky
Published 2016-01-01

Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer

by Dennis Wang, Nhu-An Pham, Timothy M. Freeman, Vibha Raghavan, Roya Navab, Jonathan Chang, Chang-Qi Zhu, Dalam Ly, Jiefei Tong, Bradly G. Wouters, Melania Pintilie, Michael F. Moran, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao
Published 2019-07-01

MK3 modulation affects BMI1-dependent and independent cell cycle check-points.

by Peggy Prickaerts, Hanneke E C Niessen, Vivian E H Dahlmans, Frank Spaapen, Juliette Salvaing, Jolien Vanhove, Claudia Geijselaers, Stefanie J J Bartels, Iris Partouns, Dietbert Neumann, Ernst-Jan Speel, Yoshihiro Takihara, Bradly G Wouters, Jan Willem Voncken
Published 2015-01-01

PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification

by Frank Spaapen, Lars M. T. Eijssen, Michiel E. Adriaens, Tim J. Welting, Peggy Prickaerts, Juliette Salvaing, Vivian E. H. Dahlmans, Donald A. M. Surtel, Frans Kruitz, Roel Kuijer, Yoshihiro Takihara, Hendrik Marks, Hendrik G. Stunnenberg, Bradly G. Wouters, Miguel Vidal, Jan Willem Voncken
Published 2017-12-01

Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

by Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J. Pugh, Carl Virtanen, Jason Moffat, Reidar A. Grénman, Marianne Koritzinsky, Bradly G. Wouters
Published 2023-05-01

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

by Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Yadong Wang, Anqi Ma, Cherry Leung, Genna M. Luciani, Jennifer Haynes, Aaron Pollett, Constanze Zeller, Shili Duan, Antonija Kreso, Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Daniel D. De Carvalho, Mathieu Lupien, Cheryl H. Arrowsmith, Catherine A. O’Brien
Published 2019-03-01

Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

by Rajesha Rupaimoole, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Chad V. Pecot, Kshipra M. Gharpure, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Michael McGuire, Behrouz Zand, Heather J. Dalton, Justyna Filant, Justin Bottsford Miller, Chunhua Lu, Nouara C. Sadaoui, Lingegowda S. Mangala, Morgan Taylor, Twan van den Beucken, Elizabeth Koch, Cristian Rodriguez-Aguayo, Li Huang, Menashe Bar-Eli, Bradly G. Wouters, Milan Radovich, Mircea Ivan, George A. Calin, Wei Zhang, Gabriel Lopez-Berestein, Anil K. Sood
Published 2020-06-01

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

by Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Published 2020-08-01

ONECUT2 is a driver of neuroendocrine prostate cancer

by Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie Tony Hua, Fraser Soares, Dong Lin, Loredana Puca, Aram Vosoughi, Hui Xue, Estelle Li, Peiran Su, Sujun Chen, Tran Nguyen, Yi Liang, Yuzhe Zhang, Xin Xu, Jing Xu, Anjali V. Sheahan, Wail Ba-Alawi, Si Zhang, Osman Mahamud, Ravi N. Vellanki, Martin Gleave, Robert G. Bristow, Benjamin Haibe-Kains, John T. Poirier, Charles M. Rudin, Ming-Sound Tsao, Bradly G. Wouters, Ladan Fazli, Felix Y. Feng, Leigh Ellis, Theo van der Kwast, Alejandro Berlin, Marianne Koritzinsky, Paul C. Boutros, Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Housheng Hansen He
Published 2019-01-01

Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma

by Stephen M.F. Jamieson, Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John J. Nemunaitis, Dennis Kee, Avik Shome, Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R.H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar A. Grénman, Laura Caporiccio, Trevor D. McKee, Mark Zaidi, Sehrish Butt, Andrew M.J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan K. Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin G. Print, William R. Wilson, Michael A. Curran, Francis W. Hunter
Published 2023-02-01

Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer

by Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I. Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe V. Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pagès, Jérôme Galon
Published 2023-01-01

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

by Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I. Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe V. Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pagès, Yutaka Kawakami, Jérôme Galon
Published 2022-09-01

Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects

by Molavian, Hamid R., Goldman, Aaron, Phipps, Colin J., Kohandel, Mohammad, Wouters, Bradly G., Sengupta, Shiladitya, Sivaloganathan, Sivabal
Published 2016