Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

by Jenny van Dongen, Gonneke Willemsen, BIOS Consortium, Eco JC de Geus, Dorret I Boomsma, Michael C Neale
Published 2023-08-01

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

by Eleonora Porcu, Sina Rüeger, Kaido Lepik, eQTLGen Consortium, BIOS Consortium, Federico A. Santoni, Alexandre Reymond, Zoltán Kutalik
Published 2019-07-01

Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids

by Adriaan van der Graaf, Annique Claringbould, Antoine Rimbert, BIOS Consortium, Harm-Jan Westra, Yang Li, Cisca Wijmenga, Serena Sanna
Published 2020-10-01

The inactive X chromosome accumulates widespread epigenetic variability with age

by Yunfeng Liu, Lucy Sinke, Thomas H. Jonkman, Roderick C. Slieker, BIOS Consortium, Erik W. van Zwet, Lucia Daxinger, Bastiaan T. Heijmans
Published 2023-08-01

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

by Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, BIOS Consortium, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra, Lude Franke
Published 2021-03-01

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

by Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke
Published 2024-01-01

Limited evidence for blood eQTLs in human sexual dimorphism

by Eleonora Porcu, Annique Claringbould, Antoine Weihs, Kaido Lepik, BIOS Consortium, Tom G. Richardson, Uwe Völker, Federico A. Santoni, Alexander Teumer, Lude Franke, Alexandre Reymond, Zoltán Kutalik
Published 2022-08-01

Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation

by Zoha Kamali, Jacob M. Keaton, Shaghayegh Haghjooy Javanmard, International Consortium of Blood Pressure, Million Veteran Program, eQTLGen Consortium, BIOS Consortium, Todd L. Edwards, Harold Snieder, Ahmad Vaez
Published 2022-07-01

Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

by Mi Kyeong Lee, Cheng-Jian Xu, Megan U. Carnes, Cody E. Nichols, James M. Ward, The BIOS consortium, Sung Ok Kwon, Sun-Young Kim, Woo Jin Kim, Stephanie J. London
Published 2019-02-01

Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies

by Anna Niehues, Daniele Bizzarri, Marcel J.T. Reinders, P. Eline Slagboom, Alain J. van Gool, Erik B. van den Akker, BBMRI-NL BIOS consortium, BBMRI-NL Metabolomics consortium, Peter A.C. ’t Hoen
Published 2022-07-01

DNA methylation is associated with lung function in never smokers

by Maaike de Vries, Ivana Nedeljkovic, Diana A. van der Plaat, Alexandra Zhernakova, Lies Lahousse, Guy G. Brusselle, BIOS Consortium, Najaf Amin, Cornelia M. van Duijn, Judith M. Vonk, H. Marike Boezen
Published 2019-12-01

Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

by Jeroen van Rooij, Pooja R. Mandaviya, Annique Claringbould, Janine F. Felix, Jenny van Dongen, Rick Jansen, Lude Franke, BIOS consortium, Peter A. C. ’t Hoen, Bas Heijmans, Joyce B. J. van Meurs
Published 2019-11-01

Genome-Wide DNA Methylation Profiles in Whole-Blood and Buccal Samples—Cross-Sectional, Longitudinal, and across Platforms

by Austin J. Van Asselt, Jeffrey J. Beck, Casey T. Finnicum, Brandon N. Johnson, Noah Kallsen, Jouke Jan Hottenga, Eco J. C. de Geus, BIOS Consortium, Dorret I. Boomsma, Erik A. Ehli, Jenny van Dongen
Published 2023-09-01

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure

by Roy Oelen, Dylan H. de Vries, Harm Brugge, M. Grace Gordon, Martijn Vochteloo, single-cell eQTLGen consortium, BIOS Consortium, Chun J. Ye, Harm-Jan Westra, Lude Franke, Monique G. P. van der Wijst
Published 2022-06-01

Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response

by Koen F. Dekkers, Roderick C. Slieker, Andreea Ioan-Facsinay, Maarten van Iterson, BIOS consortium, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Jan H. Veldink, Lude Franke, Dorret I. Boomsma, P. Eline Slagboom, J. Wouter Jukema, Bastiaan T. Heijmans
Published 2023-02-01

Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification

by Xiaoling Zhang, Jeroen G. J. van Rooij, Yoshiyuki Wakabayashi, Shih-Jen Hwang, Yanqin Yang, Mohsen Ghanbari, Daniel Bos, BIOS Consortium, Daniel Levy, Andrew D. Johnson, Joyce B. J. van Meurs, Maryam Kavousi, Jun Zhu, Christopher J. O’Donnell
Published 2021-02-01

RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting

by Bharati Jadhav, Ramin Monajemi, Kristina K. Gagalova, Daniel Ho, Harmen H. M. Draisma, Mark A. van de Wiel, Lude Franke, Bastiaan T. Heijmans, Joyce van Meurs, Rick Jansen, GoNL Consortium, BIOS Consortium, Peter A. C. ‘t Hoen, Andrew J. Sharp, Szymon M. Kiełbasa
Published 2019-06-01

A SNP panel for identification of DNA and RNA specimens

by Soheil Yousefi, Tooba Abbassi-Daloii, Thirsa Kraaijenbrink, Martijn Vermaat, Hailiang Mei, Peter van ‘t Hof, Maarten van Iterson, Daria V. Zhernakova, Annique Claringbould, Lude Franke, Leen M. ‘t Hart, Roderick C. Slieker, Amber van der Heijden, Peter de Knijff, BIOS consortium, Peter A. C. ’t Hoen
Published 2018-01-01

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

by Shuang Li, Katharina T. Schmid, Dylan H. de Vries, Maryna Korshevniuk, Corinna Losert, Roy Oelen, Irene V. van Blokland, BIOS Consortium, sc-eQTLgen Consortium, Hilde E. Groot, Morris A. Swertz, Pim van der Harst, Harm-Jan Westra, Monique G.P. van der Wijst, Matthias Heinig, Lude Franke
Published 2023-04-01

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

by Paul J. Hop, René Luijk, Lucia Daxinger, Maarten van Iterson, Koen F. Dekkers, Rick Jansen, BIOS Consortium, Joyce B. J. van Meurs, Peter A. C. ’t Hoen, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Dorret I. Boomsma, P. Eline Slagboom, Jan H. Veldink, Erik W. van Zwet, Bastiaan T. Heijmans
Published 2020-08-01