Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis

by Go Sato, Yuya Shirai, Shinichi Namba, Ryuya Edahiro, Kyuto Sonehara, Tsuyoshi Hata, Mamoru Uemura, the Biobank Japan Project, Koichi Matsuda, Yuichiro Doki, Hidetoshi Eguchi, Yukinori Okada
Published 2023-06-01

Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals

by Masato Akiyama, Saori Sakaue, Atsushi Takahashi, Kazuyoshi Ishigaki, Makoto Hirata, Koichi Matsuda, Yukihide Momozawa, Yukinori Okada, Toshiharu Ninomiya, The Biobank Japan project, Chikashi Terao, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Published 2023-02-01

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

by Qingbo S. Wang, David R. Kelley, Jacob Ulirsch, Masahiro Kanai, Shuvom Sadhuka, Ran Cui, Carlos Albors, Nathan Cheng, Yukinori Okada, The Biobank Japan Project, Francois Aguet, Kristin G. Ardlie, Daniel G. MacArthur, Hilary K. Finucane
Published 2021-06-01

Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias

by Keiko Hikino, M.D., Ph.D, Masaru Koido, Ph.D., Kohei Tomizuka, B.S., Xiaoxi Liu, Ph.D., Yukihide Momozawa, D.V.M., Ph.D., Takayuki Morisaki, M.D., Ph.D., Yoshinori Murakami, M.D., Ph.D., The Biobank Japan Project, Taisei Mushiroda, Ph.D., Chikashi Terao, M.D., Ph.D.
Published 2021-08-01

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

by Sanni E. Ruotsalainen, Ida Surakka, Nina Mars, Juha Karjalainen, Mitja Kurki, Masahiro Kanai, Kristi Krebs, Sarah Graham, Pashupati P. Mishra, Binisha H. Mishra, Juha Sinisalo, Priit Palta, Terho Lehtimäki, Olli Raitakari, Estonian Biobank Research Team, Lili Milani, The Biobank Japan Project, Yukinori Okada, FinnGen, Aarno Palotie, Elisabeth Widen, Mark J. Daly, Samuli Ripatti
Published 2022-08-01

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

by Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Published 2021-02-01

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

by Gharahkhani, Puya, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P, Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W, Segrè, Ayellet V, Rouhana, John M, Hamel, Andrew R, Igo, Robert P, Choquet, Helene, Qassim, Ayub, Josyula, Navya S, Cooke Bailey, Jessica N, Bonnemaijer, Pieter WM, Iglesias, Adriana, Siggs, Owen M, Young, Terri L, Vitart, Veronique, Thiadens, Alberta AHJ, Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B, Nair, K Saidas, Luben, Robert, Simcoe, Mark, Amersinghe, Nishani, Cree, Angela J, Hohn, Rene, Poplawski, Alicia, Chen, Li Jia, Rong, Shi-Song, Aung, Tin, Vithana, Eranga Nishanthie, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya, Gen, Shiga, Yukihiro, Yamamoto, Masayuki, Nakazawa, Toru, Currant, Hannah, Birney, Ewan, Wang, Xin, Auton, Adam, Lupton, Michelle K, Martin, Nicholas G, Ashaye, Adeyinka, Olawoye, Olusola, Williams, Susan E, Akafo, Stephen, Ramsay, Michele, Hashimoto, Kazuki, Kamatani, Yoichiro, Akiyama, Masato, Momozawa, Yukihide, Foster, Paul J, Khaw, Peng T, Morgan, James E, Strouthidis, Nicholas G, Kraft, Peter, Kang, Jae H, Pang, Chi Pui, Pasutto, Francesca, Mitchell, Paul, Lotery, Andrew J, Palotie, Aarno, van Duijn, Cornelia, Haines, Jonathan L, Hammond, Chris, Pasquale, Louis R, Klaver, Caroline CW, Hauser, Michael, Khor, Chiea Chuen, Mackey, David A, Kubo, Michiaki, Cheng, Ching-Yu, Craig, Jamie E, MacGregor, Stuart, Wiggs, Janey L
Published 2021

Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study.

by Liu, Yi-Shian, Wu, Pei-Ei, Chou, Wen-Cheng, Vikram, Rajeev, Chen, Wei-Ting, Yang, Show-Ling, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Chan, Tsun L, Choi, Ji-Yeob, Hou, Ming-Feng, Ito, Hidemi, Kang, Daehee, Kim, Sung-Won, Kwong, Ava, Matsuo, Keitaro, Park, Sue K, Shu, Xiao-Ou, Zheng, Wei, Dunning, Alison M, Easton, Douglas F, Shen, Chen-Yang
Published 2021

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

by Gharahkhani, Puya, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P, Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W, Segrè, Ayellet V, Rouhana, John M, Hamel, Andrew R, Igo, Robert P, Choquet, Helene, Qassim, Ayub, Josyula, Navya S, Cooke Bailey, Jessica N, Bonnemaijer, Pieter WM, Iglesias, Adriana, Siggs, Owen M, Young, Terri L, Vitart, Veronique, Thiadens, Alberta AHJ, Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B, Nair, K Saidas, Luben, Robert, Simcoe, Mark, Amersinghe, Nishani, Cree, Angela J, Hohn, Rene, Poplawski, Alicia, Chen, Li Jia, Rong, Shi-Song, Aung, Tin, Vithana, Eranga Nishanthie, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya, Gen, Shiga, Yukihiro, Yamamoto, Masayuki, Nakazawa, Toru, Currant, Hannah, Birney, Ewan, Wang, Xin, Auton, Adam, Lupton, Michelle K, Martin, Nicholas G, Ashaye, Adeyinka, Olawoye, Olusola, Williams, Susan E, Akafo, Stephen, Ramsay, Michele, Hashimoto, Kazuki, Kamatani, Yoichiro, Akiyama, Masato, Momozawa, Yukihide, Foster, Paul J, Khaw, Peng T, Morgan, James E, Strouthidis, Nicholas G, Kraft, Peter, Kang, Jae H, Pang, Chi Pui, Pasutto, Francesca, Mitchell, Paul, Lotery, Andrew J, Palotie, Aarno, van Duijn, Cornelia, Haines, Jonathan L, Hammond, Chris, Pasquale, Louis R, Klaver, Caroline CW, Hauser, Michael, Khor, Chiea Chuen, Mackey, David A, Kubo, Michiaki, Cheng, Ching-Yu, Craig, Jamie E, MacGregor, Stuart, Wiggs, Janey L
Published 2021

Genetic insights into biological mechanisms governing human ovarian ageing.

by Ruth, Katherine S, Day, Felix R, Hussain, Jazib, Martínez-Marchal, Ana, Aiken, Catherine E, Azad, Ajuna, Thompson, Deborah J, Knoblochova, Lucie, Abe, Hironori, Tarry-Adkins, Jane L, Gonzalez, Javier Martin, Fontanillas, Pierre, Claringbould, Annique, Bakker, Olivier B, Sulem, Patrick, Walters, Robin G, Terao, Chikashi, Turon, Sandra, Horikoshi, Momoko, Lin, Kuang, Onland-Moret, N Charlotte, Sankar, Aditya, Hertz, Emil Peter Thrane, Timshel, Pascal N, Shukla, Vallari, Borup, Rehannah, Olsen, Kristina W, Aguilera, Paula, Ferrer-Roda, Mònica, Huang, Yan, Stankovic, Stasa, Timmers, Paul RHJ, Ahearn, Thomas U, Alizadeh, Behrooz Z, Naderi, Elnaz, Andrulis, Irene L, Arnold, Alice M, Aronson, Kristan J, Augustinsson, Annelie, Bandinelli, Stefania, Barbieri, Caterina M, Beaumont, Robin N, Becher, Heiko, Beckmann, Matthias W, Benonisdottir, Stefania, Bergmann, Sven, Bochud, Murielle, Boerwinkle, Eric, Bojesen, Stig E, Bolla, Manjeet K, Boomsma, Dorret I, Bowker, Nicholas, Brody, Jennifer A, Broer, Linda, Buring, Julie E, Campbell, Archie, Campbell, Harry, Castelao, Jose E, Catamo, Eulalia, Chanock, Stephen J, Chenevix-Trench, Georgia, Ciullo, Marina, Corre, Tanguy, Couch, Fergus J, Cox, Angela, Crisponi, Laura, Cross, Simon S, Cucca, Francesco, Czene, Kamila, Smith, George Davey, de Geus, Eco JCN, de Mutsert, Renée, De Vivo, Immaculata, Demerath, Ellen W, Dennis, Joe, Dunning, Alison M, Dwek, Miriam, Eriksson, Mikael, Esko, Tõnu, Fasching, Peter A, Faul, Jessica D, Ferrucci, Luigi, Franceschini, Nora, Frayling, Timothy M, Gago-Dominguez, Manuela, Mezzavilla, Massimo, García-Closas, Montserrat, Gieger, Christian, Giles, Graham G, Grallert, Harald, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Guénel, Pascal, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hayward, Caroline, He, Chunyan, He, Wei, Heiss, Gerardo, Høffding, Miya K, Hopper, John L, Hottenga, Jouke J, Hu, Frank, Hunter, David, Ikram, Mohammad A, Jackson, Rebecca D, Joaquim, Micaella DR, John, Esther M, Joshi, Peter K, Karasik, David, Kardia, Sharon LR, Kartsonaki, Christiana, Karlsson, Robert, Kitahara, Cari M, Kolcic, Ivana, Kooperberg, Charles, Kraft, Peter, Kurian, Allison W, Kutalik, Zoltan, La Bianca, Martina, LaChance, Genevieve, Langenberg, Claudia, Launer, Lenore J, Laven, Joop SE, Lawlor, Deborah A, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lindstrom, Sara, Lindstrom, Tricia, Linet, Martha, Liu, YongMei, Liu, Simin, Luan, Jian'an, Mägi, Reedik, Magnusson, Patrik KE, Mangino, Massimo, Mannermaa, Arto, Marco, Brumat, Marten, Jonathan, Martin, Nicholas G, Mbarek, Hamdi, McKnight, Barbara, Medland, Sarah E, Meisinger, Christa, Meitinger, Thomas, Menni, Cristina, Metspalu, Andres, Milani, Lili, Milne, Roger L, Montgomery, Grant W, Mook-Kanamori, Dennis O, Mulas, Antonella, Mulligan, Anna M, Murray, Alison, Nalls, Mike A, Newman, Anne, Noordam, Raymond, Nutile, Teresa, Nyholt, Dale R, Olshan, Andrew F, Olsson, Håkan, Painter, Jodie N, Patel, Alpa V, Pedersen, Nancy L, Perjakova, Natalia, Peters, Annette, Peters, Ulrike, Pharoah, Paul DP, Polasek, Ozren, Porcu, Eleonora, Psaty, Bruce M, Rahman, Iffat, Rennert, Gad, Rennert, Hedy S, Ridker, Paul M, Ring, Susan M, Robino, Antonietta, Rose, Lynda M, Rosendaal, Frits R, Rossouw, Jacques, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Sala, Cinzia F, Saloustros, Emmanouil, Sandler, Dale P, Sanna, Serena, Sawyer, Elinor J, Sarnowski, Chloé, Schlessinger, David, Schmidt, Marjanka K, Schoemaker, Minouk J, Schraut, Katharina E, Scott, Christopher, Shekari, Saleh, Shrikhande, Amruta, Smith, Albert V, Smith, Blair H, Smith, Jennifer A, Sorice, Rossella, Southey, Melissa C, Spector, Tim D, Spinelli, John J, Stampfer, Meir, Stöckl, Doris, van Meurs, Joyce BJ, Strauch, Konstantin, Styrkarsdottir, Unnur, Swerdlow, Anthony J, Tanaka, Toshiko, Teras, Lauren R, Teumer, Alexander, Þorsteinsdottir, Unnur, Timpson, Nicholas J, Toniolo, Daniela, Traglia, Michela, Troester, Melissa A, Truong, Thérèse, Tyrrell, Jessica, Uitterlinden, André G, Ulivi, Sheila, Vachon, Celine M, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wang, Qin, Wareham, Nicholas J, Weinberg, Clarice R, Weir, David R, Wilcox, Amber N, van Dijk, Ko Willems, Willemsen, Gonneke, Wilson, James F, Wolffenbuttel, Bruce HR, Wolk, Alicja, Wood, Andrew R, Zhao, Wei, Zygmunt, Marek, Biobank-based Integrative Omics Study (BIOS) Consortium, eQTLGen Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, kConFab Investigators, LifeLines Cohort Study, InterAct consortium, 23andMe Research Team, Chen, Zhengming, Li, Liming, Franke, Lude, Burgess, Stephen, Deelen, Patrick, Pers, Tune H, Grøndahl, Marie Louise, Andersen, Claus Yding, Pujol, Anna, Lopez-Contreras, Andres J, Daniel, Jeremy A, Stefansson, Kari, Chang-Claude, Jenny, van der Schouw, Yvonne T, Lunetta, Kathryn L, Chasman, Daniel I, Easton, Douglas F, Visser, Jenny A, Ozanne, Susan E, Namekawa, Satoshi H, Solc, Petr, Murabito, Joanne M, Ong, Ken K, Hoffmann, Eva R, Murray, Anna, Roig, Ignasi, Perry, John RB
Published 2021

Genetic insights into biological mechanisms governing human ovarian ageing

by Ruth, K.S., Day, F.R., Hussain, J., Martinez-Marchal, A., Aiken, C.E., Azad, A., Thompson, D.J., Knoblochova, L., Abe, H., Tarry-Adkins, J.L., Gonzalez, J.M., Fontanillas, P., Claringbould, A., Bakker, O.B., Sulem, P., Walters, R.G., Terao, C., Turon, S., Horikoshi, M., Lin, K., Onland-Moret, N.C., Sankar, A., Hertz, E.P.T., Timshel, P.N., Shukla, V., Borup, R., Olsen, K.W., Aguilera, P., Ferrer-Roda, M., Huang, Y., Stankovic, S., Timmers, P.R.H.J., Ahearn, T.U., Alizadeh, B.Z., Naderi, E., Andrulis, I.L., Arnold, A.M., Aronson, K.J., Augustinsson, A., Bandinelli, S., Barbieri, C.M., Beaumont, R.N., Becher, H., Beckmann, M.W., Benonisdottir, S., Bergmann, S., Bochud, M., Boerwinkle, E., Bojesen, S.E., Bolla, M.K., Boomsma, D.I., Bowker, N., Brody, J.A., Broer, L., Buring, J.E., Campbell, A., Campbell, H., Castelao, J.E., Catamo, E., Chanock, S.J., Chenevix-Trench, G., Ciullo, M., Corre, T., Couch, F.J., Cox, A., Crisponi, L., Cross, S.S., Cucca, F., Czene, K., Smith, G.D., Geus, E.J.C.N. de, Mutsert, R. de, Vivo, I. de, Demerath, E.W., Dennis, J., Dunning, A.M., Dwek, M., Eriksson, M., Esko, T., Fasching, P.A., Faul, J.D., Ferrucci, L., Franceschini, N., Frayling, T.M., Gago-Dominguez, M., Mezzavilla, M., Garcia-Closas, M., Gieger, C., Giles, G.G., Grallert, H., Gudbjartsson, D.F., Gudnason, V., Guenel, P., Haiman, C.A., Hakansson, N., Hall, P., Hayward, C., He, C.Y., He, W., Heiss, G., Hoffding, M.K., Hopper, J.L., Hottenga, J.J., Hu, F., Hunter, D., Ikram, M.A., Jackson, R.D., Joaquim, M.D.R., John, E.M., Joshi, P.K., Karasik, D., Kardia, S.L.R., Kartsonaki, C., Karlsson, R., Kitahara, C.M., Kolcic, I., Kooperberg, C., Kraft, P., Kurian, A.W., Kutalik, Z., Bianca, M. la, LaChance, G., Langenberg, C., Launer, L.J., Laven, J.S.E., Lawlor, D.A., Marchand, L. le, Li, J.M., Lindblom, A., Lindstrom, S., Lindstrom, T., Linet, M., Liu, Y.M., Liu, S.M., Luan, J.N., Magi, R., Magnusson, P.K.E., Mangino, M., Mannermaa, A., Marco, B., Marten, J., Martin, N.G., Mbarek, H., McKnight, B., Medland, S.E., Meisinger, C., Meitinger, T., Menni, C., Metspalu, A., Milani, L., Milne, R.L., Montgomery, G.W., Mook-Kanamori, D.O., Mulas, A., Mulligan, A.M., Murray, A., Nalls, M.A., Newman, A., Noordam, R., Nutile, T., Nyholt, D.R., Olshan, A.F., Olsson, H., Painter, J.N., Patel, A.V., Pedersen, N.L., Perjakova, N., Peters, A., Peters, U., Pharoah, P.D.P., Polasek, O., Porcu, E., Psaty, B.M., Rahman, I., Rennert, G., Rennert, H.S., Ridker, P.M., Ring, S.M., Robino, A., Rose, L.M., Rosendaal, F.R., Rossouw, J., Rudan, I., Rueedi, R., Ruggiero, D., Sala, C.F., Saloustros, E., Sandler, D.P., Sanna, S., Sawyer, E.J., Sarnowski, C., Schlessinger, D., Schmidt, M.K., Schoemaker, M.J., Schraut, K.E., Scott, C., Shekari, S., Shrikhande, A., Smith, A.V., Smith, B.H., Smith, J.A., Sorice, R., Southey, M.C., Spector, T.D., Spinelli, J.J., Stampfer, M., Stockl, D., Meurs, J.B.J. van, Strauch, K., Styrkarsdottir, U., Swerdlow, A.J., Tanaka, T., Teras, L.R., Teumer, A., Thorsteinsdottir, U., Timpson, N.J., Toniolo, D., Traglia, M., Troester, M.A., Truong, T., Tyrrell, J., Uitterlinden, A.G., Ulivi, S., Vachon, C.M., Vitart, V., Volker, U., Vollenweider, P., Volzke, H., Wang, Q., Wareham, N.J., Weinberg, C.R., Weir, D.R., Wilcox, A.N., Dijk, K.W. van, Willemsen, G., Wilson, J.F., Wolffenbuttel, B.H.R., Wolk, A., Wood, A.R., Zhao, W., Zygmunt, M., Chen, Z.M., Li, L.M., Franke, L., Burgess, S., Deelen, P., Pers, T.H., Grondahl, M.L., Andersen, C.Y., Pujol, A., Lopez-Contreras, A.J., Daniel, J.A., Stefansson, K., Chang-Claude, J., Schouw, Y.T. van der, Lunetta, K.L., Chasman, D.I., Easton, D.F., Visser, J.A., Ozanne, S.E., Namekawa, S.H., Solc, P., Murabito, J.M., Ong, K.K., Hoffmann, E.R., Roig, I., Perry, J.R.B., Biobank-based Integrative Omics St, eQTLGen Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborati, kConFab Investigators, LifeLines Cohort Study, InterAct Consortium, 23 Me Res Team
Published 2021