Streamlining Randomized Clinical Trials for Device Therapies in Heart Failure: Bayesian Borrowing of External Data

by Benjamin R. Saville, Daniel Burkhoff, William T. Abraham
Published 2024-02-01

Choosing primary endpoints for clinical trials of health care interventions

by Charlie McLeod, Richard Norman, Edward Litton, Benjamin R. Saville, Steve Webb, Thomas L. Snelling
Published 2019-12-01

Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH): Study protocol for a multi-centered two-arm randomized adaptive trial

by Jonathan J. Ratcliff, Jonathan J. Ratcliff, Alex J. Hall, Edoardo Porto, Benjamin R. Saville, Benjamin R. Saville, Roger J. Lewis, Roger J. Lewis, Jason W. Allen, Jason W. Allen, Michael Frankel, David W. Wright, Daniel L. Barrow, Gustavo Pradilla
Published 2023-03-01

Trial Refresh: A Case for an Adaptive Platform Trial for Pulmonary Exacerbations of Cystic Fibrosis

by Andre Schultz, Andre Schultz, Andre Schultz, Julie A. Marsh, Julie A. Marsh, Benjamin R. Saville, Benjamin R. Saville, Richard Norman, Peter G. Middleton, Hugh W. Greville, Matthew I. Bellgard, Scott M. Berry, Tom Snelling, Tom Snelling, Tom Snelling, Tom Snelling
Published 2019-03-01

A trial like ALIC4E: why design a platform, response-adaptive, open, randomised controlled trial of antivirals for influenza-like illness?

by Christopher C. Butler, Samuel Coenen, Benjamin R. Saville, Johanna Cook, Alike van der Velden, Jane Homes, Menno de Jong, Paul Little, Herman Goossens, Philippe Beutels, Margareta Ieven, Nick Francis, Pieter Moons, Emily Bongard, Theo Verheij
Published 2018-05-01

A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform tri...

by Robert K. Mahar, Anna McGlothlin, Michael Dymock, Todd C. Lee, Roger J. Lewis, Thomas Lumley, Jocelyn Mora, David J. Price, Benjamin R. Saville, Tom Snelling, Rebecca Turner, Steven A. Webb, Joshua S. Davis, Steven Y. C. Tong, Julie A. Marsh, on behalf of the SNAP Global Trial Steering Committee
Published 2023-12-01

Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community tr...

by Jienchi Dorward, Susan Hopkins, Gail Hayward, Ly-Mee Yu, Oliver van Hecke, Julie Allen, Emma Ogburn, Heather Rutter, Oghenekome Gbinigie, Sharon Tonner, Aleksandra Borek, Philip H Evans, Martin Llewelyn, Benjamin R Saville, Nicholas Berry, Hannah Swayze, David Judge, Jenna Grabey, Nicholas P B Thomas, Monique I Andersson, Mahendra Patel
Published 2021-06-01

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial...

by Najib Rahman, Andrew Carson-Stevens, Stavros Petrou, Judith Breuer, Paul Little, Melissa Dobson, Kerenza Hood, Jienchi Dorward, May Ee Png, Richard Hobbs, Gail Hayward, Mark Lown, Nigel Hart, Ly-Mee Yu, Nick Francis, Philip Evans, Oliver van Hecke, Julie Allen, Joseph F Standing, Emma Ogburn, Jennifer Davies, Christopher C Butler, Saye Khoo, Andrew Ustianowski, Victoria Harris, Bhautesh Jani, Jane Holmes, Heather Rutter, Oghenekome Gbinigie, Lucy Cureton, Sarah Barrett, Benjamin R Saville, Nicholas P B Thomas, Monique I Andersson, Mahendra Patel, Jonathan Nguyen-Van-Tam, Duncan Richards, Layla Lavallee, David M Lowe, Tracie-Ann Madden, Joe Marion, Jem Chalk, Elizabeth Hadley, Magdalena Benysek, Mona Koshkouei, Maria Coates, Clare Bateman, Ivy Raymundo-Wood
Published 2023-08-01