Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies.

by Benedikt Frieg, Boris Görg, Nadine Homeyer, Verena Keitel, Dieter Häussinger, Holger Gohlke
Published 2016-02-01

Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways

by Till El Harrar, Benedikt Frieg, Mehdi D. Davari, Karl-Erich Jaeger, Ulrich Schwaneberg, Holger Gohlke
Published 2021-01-01

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)

by Benedikt Frieg, Mookyoung Han, Karin Giller, Christian Dienemann, Dietmar Riedel, Stefan Becker, Loren B. Andreas, Christian Griesinger, Gunnar F. Schröder
Published 2024-02-01

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

by Abhishek Cukkemane, Nina Becker, Mara Zielinski, Benedikt Frieg, Nils-Alexander Lakomek, Henrike Heise, Gunnar F. Schröder, Dieter Willbold, Oliver H. Weiergräber
Published 2021-12-01

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

by Mahesh Kondapuram, Benedikt Frieg, Sezin Yüksel, Tina Schwabe, Christian Sattler, Marco Lelle, Andrea Schweinitz, Ralf Schmauder, Klaus Benndorf, Holger Gohlke, Jana Kusch
Published 2022-05-01

EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay.

by Tobias Kroeger, Benedikt Frieg, Tao Zhang, Finn K Hansen, Andreas Marmann, Peter Proksch, Luitgard Nagel-Steger, Georg Groth, Sander H J Smits, Holger Gohlke
Published 2017-01-01

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein

by Benedikt Frieg, James A. Geraets, Timo Strohäker, Christian Dienemann, Panagiota Mavroeidi, Byung Chul Jung, Woojin S. Kim, Seung-Jae Lee, Maria Xilouri, Markus Zweckstetter, Gunnar F. Schröder
Published 2022-09-01

The 3D structure of lipidic fibrils of α-synuclein

by Benedikt Frieg, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot, Loren B. Andreas, Stefan Becker, Christian Griesinger, Gunnar F. Schröder
Published 2022-11-01

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

by Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas
Published 2022-09-01

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

by Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H. J. Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke
Published 2022-08-01