Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification.

by Jakub Jończyk, Barbara Malawska, Marek Bajda
Published 2017-01-01

Application of Computational Methods for the Design of BACE-1 Inhibitors: Validation of in Silico Modelling

by Marek Bajda, Jakub Jończyk, Barbara Malawska, Sławomir Filipek
Published 2014-03-01

Structure-Based Search for New Inhibitors of Cholinesterases

by Barbara Malawska, Christoph A. Sotriffer, Natalia Guzior, Michalina Hebda, Anna Więckowska, Marek Bajda
Published 2013-03-01

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

by Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda
Published 2021-01-01

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity

by Jakub Jończyk, Justyna Godyń, Ewelina Stawarska, Beata Morak-Młodawska, Małgorzata Jeleń, Krystian Pluta, Barbara Malawska
Published 2020-06-01

2,3-Dihydro-1<em>H</em>-cyclopenta[<em>b</em>]quinoline Derivatives as Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling and Biodistribution

by Elżbieta Mikiciuk-Olasik, Magdalena Markowicz, Barbara Malawska, Marek Bajda, Milan Lázniček, Alice Lázničková, Paweł Szymański
Published 2012-08-01

New Tacrine Analogs as Acetylcholinesterase Inhibitors — Theoretical Study with Chemometric Analysis

by Elżbieta Mikiciuk-Olasik, Barbara Malawska, Jakub Jończyk, Marek Bajda, Robert Skibiński, Tadeusz Inglot, Paweł Szymański
Published 2013-03-01

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agent...

by Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara Malawska
Published 2018-02-01

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

by Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska
Published 2016-03-01

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

by Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska
Published 2020-01-01

A walk through tau therapeutic strategies

by Santosh Jadhav, Jesus Avila, Michael Schöll, Gabor G. Kovacs, Enikö Kövari, Rostislav Skrabana, Lewis D Evans, Eva Kontsekova, Barbara Malawska, Rohan de Silva, Luc Buee, Norbert Zilka
Published 2019-02-01

Guanidines: Synthesis of Novel Histamine H₃R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect

by Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński
Published 2023-04-01

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

by Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek
Published 2021-01-01

Biphenylalkoxyamine Derivatives–Histamine H₃ Receptor Ligands with Butyrylcholinesterase Inhibitory Activity

by Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz
Published 2021-06-01

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

by Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Published 2016-05-01

Benzophenone Derivatives with Histamine H₃ Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Di...

by Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Published 2022-12-01