Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment

by Endika Prieto-Fernández, Leire Egia-Mendikute, Alexandre Bosch, Ana García del Río, Borja Jimenez-Lasheras, Asier Antoñana-Vildosola, So Young Lee, Asis Palazon, Asis Palazon
Published 2020-09-01

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

by Alba Rodriguez-Garcia, Asis Palazon, Estela Noguera-Ortega, Daniel J. Powell, Sonia Guedan
Published 2020-06-01

SimB16: modeling induced immune system response against B16-melanoma.

by Francesco Pappalardo, Ivan Martinez Forero, Marzio Pennisi, Asis Palazon, Ignacio Melero, Santo Motta
Published 2011-01-01

A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity

by Nadine Nelson, Marta Lopez-Pelaez, Asis Palazon, Edmund Poon, Maike De La Roche, Simon Barry, Viia Valge-Archer, Robert W. Wilkinson, Simon J. Dovedi, Paul D. Smith
Published 2019-08-01

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

by Soledad Stagnoli, Francesca Peccati, Sean R. Connell, Sean R. Connell, Sean R. Connell, Ane Martinez-Castillo, Diego Charro, Oscar Millet, Chiara Bruzzone, Asis Palazon, Asis Palazon, Ana Ardá, Ana Ardá, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, June Ereño-Orbea, June Ereño-Orbea, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Gonzalo Jiménez-Osés, Gonzalo Jiménez-Osés
Published 2022-04-01

Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis

by Colin E. Evans, Asis Palazon, Jingwei Sim, Petros A. Tyrakis, Alice Prodger, Xiao Lu, Saria Chan, Pär-Ola Bendahl, Mattias Belting, Love Von Euler, Helene Rundqvist, Randall S. Johnson, Cristina Branco
Published 2017-05-01

Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy.

by Maria C Ochoa, Jessica Fioravanti, Erwin H Duitman, Jose Medina-Echeverz, Asis Palazon, Ainhoa Arina, Juan Dubrot, Carlos Alfaro, Aizea Morales-Kastresana, Oihana Murillo, Sandra Hervas-Stubbs, Jesus Prieto, Pedro Berraondo, Ignacio Melero
Published 2012-01-01

Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.

by Carlos Alfaro, Natalia Suárez, Ivan Martínez-Forero, Asís Palazón, Ana Rouzaut, Sarai Solano, Esperanza Feijoo, Alfonso Gúrpide, Elixabet Bolaños, Lorena Erro, Juan Dubrot, Sandra Hervás-Stubbs, Alvaro Gonzalez, Jose Luis Perez-Gracia, Ignacio Melero
Published 2011-01-01

A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants

by Leire Egia-Mendikute, Alexandre Bosch, Endika Prieto-Fernández, Laura Vila-Vecilla, Samanta Romina Zanetti, So Young Lee, Borja Jiménez-Lasheras, Ana García del Río, Asier Antoñana-Vildosola, Ander de Blas, Paloma Velasco-Beltrán, Marina Serrano-Maciá, Paula Iruzubieta, Majid Mehrpouyan, Edward M. Goldberg, Scott J. Bornheimer, Nieves Embade, María L. Martínez-Chantar, María L. Martínez-Chantar, Marcos López-Hoyos, José M. Mato, José M. Mato, Óscar Millet, Óscar Millet, Asís Palazón, Asís Palazón
Published 2022-11-01

Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes.

by Carlos Alfaro, Natalia Suarez, Carmen Oñate, Jose L Perez-Gracia, Ivan Martinez-Forero, Sandra Hervas-Stubbs, Inmaculada Rodriguez, Guiomar Perez, Elixabet Bolaños, Asis Palazon, Miguel Fernandez de Sanmamed, Aizea Morales-Kastresana, Alvaro Gonzalez, Ignacio Melero
Published 2011-01-01

Factor-inhibiting HIF (FIH) promotes lung cancer progression

by Ana García-del Río, Endika Prieto-Fernández, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Borja Jimenez-Lasheras, So Young Lee, Adrián Barreira-Manrique, Samanta Romina Zanetti, Ander de Blas, Paloma Velasco-Beltrán, Alexandre Bosch, Ana M. Aransay, Asis Palazon
Published 2023-10-01

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

by Endika Prieto-Fernández, Leire Egia-Mendikute, Laura Vila-Vecilla, Alexandre Bosch, Adrián Barreira-Manrique, So Young Lee, Ana García-del Río, Asier Antoñana-Vildosola, Borja Jiménez-Lasheras, Leire Moreno-Cugnon, Jesús Jiménez-Barbero, Edurne Berra, June Ereño-Orbea, Asis Palazon
Published 2021-01-01

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

by Sara Labiano, Florinda Meléndez-Rodríguez, Asís Palazón, Álvaro Teijeira, Saray Garasa, Iñaki Etxeberria, M. Ángela Aznar, Alfonso R. Sánchez-Paulete, Arantza Azpilikueta, Elixabet Bolaños, Carmen Molina, Hortensia de la Fuente, Patricia Maiso, Francisco Sánchez-Madrid, Manuel Ortiz de Landázuri, Julián Aragonés, Ignacio Melero
Published 2017-04-01

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

by Iosifina P. Foskolou, Pedro P. Cunha, Elena Sánchez-López, Eleanor A. Minogue, Benoît P. Nicolet, Aurélie Guislain, Christian Jorgensen, Sarantos Kostidis, Nordin D. Zandhuis, Laura Barbieri, David Bargiela, Demitris Nathanael, Petros A. Tyrakis, Asis Palazon, Martin Giera, Monika C. Wolkers, Randall S. Johnson
Published 2023-09-01

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

by Chiara Bruzzone, Maider Bizkarguenaga, Rubén Gil-Redondo, Tammo Diercks, Eunate Arana, Aitor García de Vicuña, Marisa Seco, Alexandre Bosch, Asís Palazón, Itxaso San Juan, Ana Laín, Jon Gil-Martínez, Ganeko Bernardo-Seisdedos, David Fernández-Ramos, Fernando Lopitz-Otsoa, Nieves Embade, Shelly Lu, José M. Mato, Oscar Millet
Published 2020-10-01

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

by Leire Egia-Mendikute, Alexandre Bosch, Endika Prieto-Fernández, So Young Lee, Borja Jiménez-Lasheras, Ana García del Río, Asier Antoñana-Vildosola, Chiara Bruzzone, Maider Bizkarguenaga, Nieves Embade, Rubén Gil-Redondo, María Luz Martínez-Chantar, Marcos López-Hoyos, Nicola G. A. Abrescia, José M. Mato, Óscar Millet, Asís Palazón
Published 2021-04-01

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients

by Marina Serrano-Maciá, Sofia Lachiondo-Ortega, Paula Iruzubieta, Naroa Goikoetxea-Usandizaga, Alexandre Bosch, Leire Egia-Mendikute, Borja Jiménez-Lasheras, Mikel Azkargorta, Félix Elortza, Diana Martinez-Redondo, Begoña Castro, Juan J. Lozano, Ruben Nogueiras, Juan Irure-Ventura, Javier Crespo, Asís Palazón, María Carmen Fariñas, Teresa C. Delgado, Marcos López-Hoyos, Maria L. Martínez-Chantar
Published 2022-07-01

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

by Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon, June Ereño-Orbea
Published 2023-06-01

An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study

by Rubén Gil-Redondo, Ricardo Conde, Maider Bizkarguenaga, Chiara Bruzzone, Ana Laín, Beatriz González-Valle, Milagros Iriberri, Carlos Ramos-Acosta, Eduardo Anguita, Juan Ignacio Arriaga Lariz, Pedro Pablo España Yandiola, Miguel Ángel Moran, Mario Ernesto Jiménez-Mercado, Leire Egia-Mendikute, María Luisa Seco, Hartmut Schäfer, Claire Cannet, Manfred Spraul, Asís Palazón, Nieves Embade, Shelly C. Lu, Julien Wist, Jeremy K. Nicholson, José M. Mato, Oscar Millet
Published 2022-12-01

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

by Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa Cardoso Delgado, Felix Elortza, Jesús Jiménez-Barbero, Ruben Nogueiras, Vincent Prevot, Asis Palazon, María L. Martínez-Chantar
Published 2022-08-01