Predictive modelling and simulation for taming the chance and luck in biologics drug discovery

by Armin Sepp
Published 2023-10-01

Application of quantitative protein mass spectrometric data in the early predictive analysis of target engagement by monoclonal antibodies

by Morris Muliaditan, Armin Sepp
Published 2022-07-01

Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies

by Armin Sepp, Morris Muliaditan
Published 2024-12-01

Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans

by Armin Sepp, Mats Bergström, Marie Davies
Published 2020-01-01

Liver-targeting of interferon-alpha with tissue-specific domain antibodies.

by Edward Coulstock, Jane Sosabowski, Milan Ovečka, Rob Prince, Laura Goodall, Clare Mudd, Armin Sepp, Marie Davies, Julie Foster, Jerome Burnet, Gráinne Dunlevy, Adam Walker
Published 2013-01-01

Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.

by Daniel Rycroft, Jane Sosabowski, Edward Coulstock, Marie Davies, John Morrey, Sarah Friel, Fiona Kelly, Robert Hamatake, Milan Ovečka, Rob Prince, Laura Goodall, Armin Sepp, Adam Walker
Published 2015-01-01

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

by Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland, Mats Bergstrom, Marie Davies
Published 2019-05-01

Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation

by Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols
Published 2021-10-01