Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.

by Smita Majumder, Arlan Richardson, Randy Strong, Salvatore Oddo
Published 2011-01-01

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

by Hongyang Xu, Rojina Ranjit, Arlan Richardson, Holly Van Remmen
Published 2021-12-01

MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice.

by JennaLynn Hunnicut, Yuhong Liu, Arlan Richardson, Adam B Salmon
Published 2015-01-01

Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice

by Adam B. Salmon, Geumsoo Kim, Chengyu Liu, Jonathan D. Wren, Constantin Georgescu, Arlan Richardson, Rodney L. Levine
Published 2016-12-01

Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

by Steve D. Guzman, Jennifer Judge, Shahjahan M. Shigdar, Thomas A. Paul, Carol S. Davis, Peter C. Macpherson, James F. Markworth, Holly Van Remmen, Holly Van Remmen, Holly Van Remmen, Arlan Richardson, Arlan Richardson, Anne McArdle, Susan V. Brooks, Susan V. Brooks
Published 2022-01-01

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.

by Patricia Spilman, Natalia Podlutskaya, Matthew J Hart, Jayanta Debnath, Olivia Gorostiza, Dale Bredesen, Arlan Richardson, Randy Strong, Veronica Galvan
Published 2010-04-01

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.

by Kathleen E Fischer, Jonathan A L Gelfond, Vanessa Y Soto, Chul Han, Shinichi Someya, Arlan Richardson, Steven N Austad
Published 2015-01-01

Correction: Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease.

by Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart, Jayanta Debnath, Olivia Gorostiza, Dale Bredesen, Arlan Richardson, Randy Strong, Veronica Galvan
Published 2011-01-01

Correction: Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease.

by Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart, Jayanta Debnath, Olivia Gorostiza, Dale Bredesen, Arlan Richardson, Randy Strong, Veronica Galvan
Published 2011-01-01

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence

by Yiqiang Zhang, Archana Unnikrishnan, Sathyaseelan S. Deepa, Yuhong Liu, Yan Li, Yuji Ikeno, Danuta Sosnowska, Holly Van Remmen, Arlan Richardson
Published 2017-04-01

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

by Yu Su, Dennis R. Claflin, Meixiang Huang, Carol S. Davis, Peter C. D. Macpherson, Arlan Richardson, Holly Van Remmen, Susan V. Brooks
Published 2021-10-01

Litter expansion alters metabolic homeostasis in a sex specific manner.

by Kavitha Kurup, Shivani N Mann, Jordan Jackson, Stephanie Matyi, Michelle Ranjo-Bishop, Willard M Freeman, Michael B Stout, Arlan Richardson, Archana Unnikrishnan
Published 2021-01-01

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

by Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Published 2018-10-01

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

by Wilson C Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B Salmon, Vivian Diaz, Martin Javors, William H Wood, Yongqing Zhang, Kevin G Becker, Viviana I Pérez, Arlan Richardson
Published 2014-01-01

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

by Alex F Bokov, Neha Garg, Yuji Ikeno, Sachin Thakur, Nicolas Musi, Ralph A DeFronzo, Ning Zhang, Rebecca C Erickson, Jon Gelfond, Gene B Hubbard, Martin L Adamo, Arlan Richardson
Published 2011-01-01

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

by Kavithalakshmi Sataranatarajan, Rizwan Qaisar, Carol Davis, Giorgos K. Sakellariou, Aphrodite Vasilaki, Yiqiang Zhang, Yuhong Liu, Shylesh Bhaskaran, Anne McArdle, Malcolm Jackson, Susan V. Brooks, Arlan Richardson, Holly Van Remmen
Published 2015-08-01

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model

by Phoebe Ohene-Marfo, Hoang Van M. Nguyen, Sabira Mohammed, Nidheesh Thadathil, Albert Tran, Evan H. Nicklas, Dawei Wang, Ramasamy Selvarani, Jacob W. Farriester, Rohan Varshney, Michael Kinter, Arlan Richardson, Michael C. Rudolph, Sathyaseelan S. Deepa
Published 2024-02-01

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis

by Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Jr., Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Published 2023-02-01

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

by Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Published 2019-04-01