Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

by Lukas Muri, Lukas Muri, Emma Ispasanie, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke
Published 2021-10-01

Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

by Lukas Muri, Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke, Emma Ispasanie, Emma Ispasanie
Published 2022-12-01

Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals

by Emma Ispasanie, Emma Ispasanie, Lukas Muri, Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke
Published 2021-10-01

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

by Emma Ispasanie, Emma Ispasanie, Lukas Muri, Lukas Muri, Marc Schmid, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke
Published 2023-06-01

The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

by Petra Hundehege, Manuela Cerina, Susann Eichler, Christian Thomas, Alexander M Herrmann, Kerstin Göbel, Thomas Müntefering, Juncal Fernandez-Orth, Stefanie Bock, Venu Narayanan, Thomas Budde, Erwin-Josef Speckmann, Heinz Wiendl, Anna Schubart, Tobias Ruck, Sven G Meuth
Published 2019-01-01

Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria

by Jun-ichi Nishimura, Kiyoshi Ando, Masayoshi Masuko, Hideyoshi Noji, Yoshikazu Ito, Jiri Mayer, Laimonas Griskevicius, Christoph Bucher, Florian Müllershausen, Peter Gergely, Izabela Rozenberg, Anna Schubart, Raghav Chawla, Jean-Michel Rondeau, Michael Roguska, Igor Splawski, Mark T. Keating, Leslie Johnson, Rambabu Danekula, Morten Bagger, Yoko Watanabe, Börje Haraldsson, Yuzuru Kanakura
Published 2022-03-01