The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

by Florian Wolff, Michael Leisch, Richard Greil, Angela Risch, Lisa Pleyer
Published 2017-03-01

Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy

by Silvia Funke, Angela Risch, Alexandra Nieters, Michael Hoffmeister, Christa Stegmaier, Christoph M. Seiler, Hermann Brenner, Jenny Chang-Claude
Published 2009-01-01

Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells

by Esther Schamschula, Angelika Lahnsteiner, Yassen Assenov, Wolfgang Hagmann, Nadja Zaborsky, Markus Wiederstein, Anna Strobl, Frauke Stanke, Thomas Muley, Christoph Plass, Burkhard Tümmler, Angela Risch
Published 2022-08-01

Comparison of pathway analysis approaches using lung cancer GWAS data sets.

by Gordon Fehringer, Geoffrey Liu, Laurent Briollais, Paul Brennan, Christopher I Amos, Margaret R Spitz, Heike Bickeböller, H Erich Wichmann, Angela Risch, Rayjean J Hung
Published 2012-01-01

Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet[S]

by Sven H. Rouschop, Tanja Karl, Angela Risch, Petronella A. van Ewijk, Vera B. Schrauwen-Hinderling, Antoon Opperhuizen, Frederik J. van Schooten, Roger W. Godschalk
Published 2019-07-01

META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies.

by Albert Rosenberger, Stefanie Friedrichs, Christopher I Amos, Paul Brennan, Gordon Fehringer, Joachim Heinrich, Rayjean J Hung, Thomas Muley, Martina Müller-Nurasyid, Angela Risch, Heike Bickeböller
Published 2015-01-01

Myeloid NGS Analyses of Paired Samples from Bone Marrow and Peripheral Blood Yield Concordant Results: A Prospective Cohort Analysis of the AGMT Study Group

by Bettina Jansko-Gadermeir, Michael Leisch, Franz J. Gassner, Nadja Zaborsky, Thomas Dillinger, Sonja Hutter, Angela Risch, Thomas Melchardt, Alexander Egle, Manuel Drost, Julian Larcher-Senn, Richard Greil, Lisa Pleyer
Published 2023-04-01

Identification of <i>NHLRC1</i> as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS)

by Christian Faltus, Angelika Lahnsteiner, Myrto Barrdahl, Yassen Assenov, Anika Hüsing, Olga Bogatyrova, Marina Laplana, Theron Johnson, Thomas Muley, Michael Meister, Arne Warth, Michael Thomas, Christoph Plass, Rudolf Kaaks, Angela Risch
Published 2022-09-01

Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

by Marina Laplana, Matthias Bieg, Christian Faltus, Svitlana Melnik, Olga Bogatyrova, Zuguang Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Esther Herpel, Christopher I. Amos, Matthias Schlesner, Roland Eils, Christoph Plass, Angela Risch
Published 2022-02-01

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

by Sandra Grund‐Gröschke, Daniela Ortner, Antal B. Szenes‐Nagy, Nadja Zaborsky, Richard Weiss, Daniel Neureiter, Martin Wipplinger, Angela Risch, Peter Hammerl, Richard Greil, Maria Sibilia, Iris K. Gratz, Patrizia Stoitzner, Fritz Aberger
Published 2020-09-01

Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus.

by Albert Rosenberger, Melanie Sohns, Stefanie Friedrichs, Rayjean J Hung, Gord Fehringer, John McLaughlin, Christopher I Amos, Paul Brennan, Angela Risch, Irene Brüske, Neil E Caporaso, Maria Teresa Landi, David C Christiani, Yongyue Wei, Heike Bickeböller
Published 2017-01-01

Buffy coat signatures of breast cancer risk in a prospective cohort study

by Felicia Fei-Lei Chung, Sandra González Maldonado, Amelie Nemc, Liacine Bouaoun, Vincent Cahais, Cyrille Cuenin, Aurelie Salle, Theron Johnson, Bekir Ergüner, Marina Laplana, Paul Datlinger, Jana Jeschke, Elisabete Weiderpass, Vessela Kristensen, Suzette Delaloge, François Fuks, Angela Risch, Akram Ghantous, Christoph Plass, Christoph Bock, Rudolf Kaaks, Zdenko Herceg
Published 2023-06-01

Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium

by Yun Feng, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Younghun Han, Rayjean J. Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeboeller, Albert Rosenberger, Richard S. Houlston, Neil E. Caporaso, Maria Teresa Landi, Irene Brueske, Angela Risch, Yuanqing Ye, Xifeng Wu, David C. Christiani, Christopher I. Amos, Qingyi Wei
Published 2017-04-01

Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk

by Wenjun Yang, Hongliang Liu, Ruoxin Zhang, Jennifer A. Freedman, Younghun Han, Rayjean J. Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeboeller, Albert Rosenberger, Richard S. Houlston, Neil E. Caporaso, Maria Teresa Landi, Irene Brueske, Angela Risch, David C. Christiani, Christopher I. Amos, Xiaoxin Chen, Steven R. Patierno, Qingyi Wei
Published 2022-06-01

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.

by Nikhil K Khankari, Xiao-Ou Shu, Wanqing Wen, Peter Kraft, Sara Lindström, Ulrike Peters, Joellen Schildkraut, Fredrick Schumacher, Paolo Bofetta, Angela Risch, Heike Bickeböller, Christopher I Amos, Douglas Easton, Rosalind A Eeles, Rosalind A Eeles, Stephen B Gruber, Christopher A Haiman, David J Hunter, Stephen J Chanock, Brandon L Pierce, Wei Zheng, Colorectal Transdisciplinary Study (CORECT), Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE), Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE), Transdisciplinary Research in Cancer of the Lung (TRICL)
Published 2016-09-01

Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

by Xinan Wang, Ziwei Zhang, Yi Ding, Tony Chen, Lorelei Mucci, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angie Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rayjean J. Hung, Christopher I. Amos, Xihong Lin, David C. Christiani
Published 2024-02-01

Methylome analysis and epigenetic changes associated with menarcheal age.

by Christiana A Demetriou, Jia Chen, Silvia Polidoro, Karin van Veldhoven, Cyrille Cuenin, Gianluca Campanella, Kevin Brennan, Françoise Clavel-Chapelon, Laure Dossus, Marina Kvaskoff, Dagmar Drogan, Heiner Boeing, Rudolf Kaaks, Angela Risch, Dimitrios Trichopoulos, Pagona Lagiou, Giovanna Masala, Sabina Sieri, Rosario Tumino, Salvatore Panico, J Ramón Quirós, María-José Sánchez Perez, Pilar Amiano, José María Huerta Castaño, Eva Ardanaz, Charlotte Onland-Moret, Petra Peeters, Kay-Tee Khaw, Nick Wareham, Timothy J Key, Ruth C Travis, Isabelle Romieu, Valentina Gallo, Marc Gunter, Zdenko Herceg, Kyriacos Kyriacou, Elio Riboli, James M Flanagan, Paolo Vineis
Published 2013-01-01

Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer

by Albert Rosenberger, Nils Muttray, Rayjean J. Hung, David C. Christiani, Neil E. Caporaso, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Guillermo Fernández-Tardón, Gad Rennert, John K. Field, Michael P. A. Davies, Triantafillos Liloglou, Lambertus A. Kiemeney, Philip Lazarus, Bernadette Wendel, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Eric J. Duell, Susanne M. Arnold, Gary E. Goodman, Chu Chen, Jennifer A. Doherty, Fiona Taylor, Angela Cox, Penella J. Woll, Angela Risch, Thomas R. Muley, Mikael Johansson, Paul Brennan, Maria Teresa Landi, Sanjay S. Shete, Christopher I. Amos, Heike Bickeböller, The INTEGRAL-ILCCO Consortium
Published 2022-01-01

Informed conditioning on clinical covariates increases power in case-control association studies.

by Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, Samuela Pollack, Anne Barton, Heike Bickeböller, Donald W Bowden, Steve Eyre, Barry I Freedman, David J Friedman, John K Field, Leif Groop, Aage Haugen, Joachim Heinrich, Brian E Henderson, Pamela J Hicks, Lynne J Hocking, Laurence N Kolonel, Maria Teresa Landi, Carl D Langefeld, Loic Le Marchand, Michael Meister, Ann W Morgan, Olaide Y Raji, Angela Risch, Albert Rosenberger, David Scherf, Sophia Steer, Martin Walshaw, Kevin M Waters, Anthony G Wilson, Paul Wordsworth, Shanbeh Zienolddiny, Eric Tchetgen Tchetgen, Christopher Haiman, David J Hunter, Robert M Plenge, Jane Worthington, David C Christiani, Debra A Schaumberg, Daniel I Chasman, David Altshuler, Benjamin Voight, Peter Kraft, Nick Patterson, Alkes L Price
Published 2012-01-01

Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis

by Li-Shiun Chen, Timothy Baker, Rayjean J. Hung, Amy Horton, Robert Culverhouse, Sarah Hartz, Nancy Saccone, Iona Cheng, Bo Deng, Younghun Han, Helen M. Hansen, Janet Horsman, Claire Kim, Albert Rosenberger, Katja K. Aben, Angeline S. Andrew, Shen-Chih Chang, Kai-Uwe Saum, Hendrik Dienemann, Dorothy K. Hatsukami, Eric O. Johnson, Mala Pande, Margaret R. Wrensch, John McLaughlin, Vidar Skaug, Erik H. van der Heijden, Jason Wampfler, Angela Wenzlaff, Penella Woll, Shanbeh Zienolddiny, Heike Bickeböller, Hermann Brenner, Eric J. Duell, Aage Haugen, Irene Brüske, Lambertus A. Kiemeney, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Jose Mayordomo, Angela Risch, Ann G. Schwartz, M. Dawn Teare, Xifeng Wu, John K. Wiencke, Ping Yang, Zuo-Feng Zhang, Margaret R. Spitz, Christopher I. Amos, Laura J. Bierut
Published 2016-09-01