Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major

by Nikoletta Psatha, Andreas Reik, Susan Phelps, Yuanyue Zhou, Demetri Dalas, Evangelia Yannaki, Dana N. Levasseur, Fyodor D. Urnov, Michael C. Holmes, Thalia Papayannopoulou
Published 2018-09-01

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy.

by Christopher W Peterson, Jianbin Wang, Claire Deleage, Sowmya Reddy, Jasbir Kaur, Patricia Polacino, Andreas Reik, Meei-Li Huang, Keith R Jerome, Shiu-Lok Hu, Michael C Holmes, Jacob D Estes, Hans-Peter Kiem
Published 2018-04-01

Epigenetic control of multiple genes with a lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

by Davide Monteferrario, Marion David, Satish K. Tadi, Yuanyue Zhou, Irène Marchetti, Caroline Jeanneau, Gaëlle Saviane, Coralie F. Dupont, Angélique E. Martelli, Lynn N. Truong, Jason A. Eshleman, Colman C. Ng, Marshall W. Huston, Gregory D. Davis, Jason D. Fontenot, Andreas Reik, Maurus de la Rosa, David Fenard
Published 2024-06-01

Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells

by Friedrich Fauser, Bhakti N. Kadam, Sebastian Arangundy-Franklin, Jessica E. Davis, Vishvesha Vaidya, Nicola J. Schmidt, Garrett Lew, Danny F. Xia, Rakshaa Mureli, Colman Ng, Yuanyue Zhou, Nicholas A. Scarlott, Jason Eshleman, Yuri R. Bendaña, David A. Shivak, Andreas Reik, Patrick Li, Gregory D. Davis, Jeffrey C. Miller
Published 2024-02-01

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

by Kai-Hsin Chang, Sarah E. Smith, Timothy Sullivan, Kai Chen, Qianhe Zhou, Jason A. West, Mei Liu, Yingchun Liu, Benjamin F. Vieira, Chao Sun, Vu P. Hong, Mingxuan Zhang, Xiao Yang, Andreas Reik, Fyodor D. Urnov, Edward J. Rebar, Michael C. Holmes, Olivier Danos, Haiyan Jiang, Siyuan Tan
Published 2017-03-01