Editorial: Inhibitors of CDK family: New perspective and rationale for drug combination in preclinical models of solid tumors

by Andrea Cavazzoni, Arianna Palladini
Published 2023-03-01

Role of Cytokines and Other Soluble Factors in Tumor Development: Rationale for New Therapeutic Strategies

by Andrea Cavazzoni, Graziana Digiacomo
Published 2023-10-01

PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition

by Daniele Cretella, Graziana Digiacomo, Elisa Giovannetti, Andrea Cavazzoni
Published 2019-09-01

Biological Hallmarks and New Therapeutic Approaches for the Treatment of PDAC

by Graziana Digiacomo, Francesco Volta, Ingrid Garajova, Rita Balsano, Andrea Cavazzoni
Published 2021-08-01

New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway

by Roberta Alfieri, Elisa Giovannetti, Elisa Giovannetti, Mara Bonelli, Andrea Cavazzoni
Published 2017-08-01

It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer

by Ingrid Garajová, Andrea Cavazzoni, Michela Verze, Roberta Minari, Giuseppe Pedrazzi, Rita Balsano, Fabio Gelsomino, Raffaele Dalla Valle, Graziana Digiacomo, Elisa Giovannetti, Francesco Leonardi
Published 2022-06-01

The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells

by Daniele Cretella, Andrea Ravelli, Claudia Fumarola, Silvia La Monica, Graziana Digiacomo, Andrea Cavazzoni, Roberta Alfieri, Alessandra Biondi, Daniele Generali, Mara Bonelli, Pier Giorgio Petronini
Published 2018-03-01

Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells

by Mara Bonelli, Rita Terenziani, Silvia Zoppi, Claudia Fumarola, Silvia La Monica, Daniele Cretella, Roberta Alfieri, Andrea Cavazzoni, Graziana Digiacomo, Maricla Galetti, Pier Giorgio Petronini
Published 2020-07-01

MYC Amplification as a Potential Mechanism of Primary Resistance to Crizotinib in ALK-Rearranged Non-Small Cell Lung Cancer: A Brief Report

by Karim Rihawi, Roberta Alfieri, Michelangelo Fiorentino, Francesca Fontana, Elisa Capizzi, Andrea Cavazzoni, Mario Terracciano, Silvia La Monica, Alberto Ferrarini, Genny Buson, Pier Giorgio Petronini, Andrea Ardizzoni
Published 2019-01-01

Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

by Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G. Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J. Peters
Published 2013-01-01

Simultaneous Combination of the CDK4/6 Inhibitor Palbociclib With Regorafenib Induces Enhanced Anti-tumor Effects in Hepatocarcinoma Cell Lines

by Graziana Digiacomo, Claudia Fumarola, Silvia La Monica, Mara A. Bonelli, Daniele Cretella, Roberta Alfieri, Andrea Cavazzoni, Maricla Galetti, Patrizia Bertolini, Gabriele Missale, Gabriele Missale, Pier Giorgio Petronini
Published 2020-09-01

Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines

by Silvia La Monica, Daniele Cretella, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Graziana Digiacomo, Lisa Flammini, Elisabetta Barocelli, Roberta Minari, Nadia Naldi, Pier Giorgio Petronini, Marcello Tiseo, Roberta Alfieri
Published 2017-12-01

Efficacy of the CDK4/6 Dual Inhibitor Abemaciclib in EGFR-Mutated NSCLC Cell Lines with Different Resistance Mechanisms to Osimertinib

by Silvia La Monica, Claudia Fumarola, Daniele Cretella, Mara Bonelli, Roberta Minari, Andrea Cavazzoni, Graziana Digiacomo, Maricla Galetti, Francesco Volta, Maicol Mancini, Pier Giorgio Petronini, Marcello Tiseo, Roberta Alfieri
Published 2020-12-01

CDK4/6 Inhibition Enhances the Efficacy of Standard Chemotherapy Treatment in Malignant Pleural Mesothelioma Cells

by Rita Terenziani, Maricla Galetti, Silvia La Monica, Claudia Fumarola, Silvia Zoppi, Roberta Alfieri, Graziana Digiacomo, Andrea Cavazzoni, Delia Cavallo, Massimo Corradi, Marcello Tiseo, Pier Giorgio Petronini, Mara Bonelli
Published 2022-11-01

Tumor-infiltrating lymphocytes and breast cancer: Beyond the prognostic and predictive utility

by Andrea Ravelli, Giandomenico Roviello, Daniele Cretella, Andrea Cavazzoni, Alessandra Biondi, Maria Rosa Cappelletti, Laura Zanotti, Giuseppina Ferrero, Marco Ungari, Fabrizio Zanconati, Alberto Bottini, Roberta Alfieri, Pier Giorgio Petronini, Daniele Generali
Published 2017-04-01

Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines.

by Maricla Galetti, Pier Giorgio Petronini, Claudia Fumarola, Daniele Cretella, Silvia La Monica, Mara Bonelli, Andrea Cavazzoni, Francesca Saccani, Cristina Caffarra, Roberta Andreoli, Antonio Mutti, Marcello Tiseo, Andrea Ardizzoni, Roberta R Alfieri
Published 2015-01-01

Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics

by Rita Balsano, Zita Kruize, Martina Lunardi, Annalisa Comandatore, Mara Barone, Andrea Cavazzoni, Andrea David Re Cecconi, Luca Morelli, Hanneke Wilmink, Marcello Tiseo, Ingrid Garajovà, Lia van Zuylen, Elisa Giovannetti, Rosanna Piccirillo
Published 2022-08-01

CDK4/6 inhibitors improve the anti-tumor efficacy of lenvatinib in hepatocarcinoma cells

by Graziana Digiacomo, Claudia Fumarola, Silvia La Monica, Mara Bonelli, Andrea Cavazzoni, Maricla Galetti, Rita Terenziani, Kamal Eltayeb, Francesco Volta, Silvia Zoppi, Patrizia Bertolini, Gabriele Missale, Gabriele Missale, Roberta Alfieri, Pier Giorgio Petronini
Published 2022-07-01

Pemetrexed Enhances Membrane PD-L1 Expression and Potentiates T Cell-Mediated Cytotoxicity by Anti-PD-L1 Antibody Therapy in Non-Small-Cell Lung Cancer

by Andrea Cavazzoni, Graziana Digiacomo, Roberta Alfieri, Silvia La Monica, Claudia Fumarola, Maricla Galetti, Mara Bonelli, Daniele Cretella, Valeria Barili, Alessandra Zecca, Elisa Giovannetti, Michelangelo Fiorentino, Marcello Tiseo, Pier Giorgio Petronini, Andrea Ardizzoni
Published 2020-03-01

Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.

by Silvia La Monica, Cristina Caffarra, Francesca Saccani, Elena Galvani, Maricla Galetti, Claudia Fumarola, Mara Bonelli, Andrea Cavazzoni, Daniele Cretella, Rita Sirangelo, Rita Gatti, Marcello Tiseo, Andrea Ardizzoni, Elisa Giovannetti, Pier Giorgio Petronini, Roberta R Alfieri
Published 2013-01-01