Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm

by Anaïs Kervadec, James Kezos, Haibo Ni, Michael Yu, James Marchant, Sean Spiering, Suraj Kannan, Chulan Kwon, Peter Andersen, Rolf Bodmer, Eleonora Grandi, Karen Ocorr, Alexandre R. Colas
Published 2023-07-01

Genetic architecture of natural variation of cardiac performance from flies to humans

by Saswati Saha, Lionel Spinelli, Jaime A Castro Mondragon, Anaïs Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R Colas, Karen Ocorr, Laurent Perrin
Published 2022-11-01

Silencing of CCR4-NOT complex subunits affects heart structure and function

by Lisa Elmén, Claudia B. Volpato, Anaïs Kervadec, Santiago Pineda, Sreehari Kalvakuri, Nakissa N. Alayari, Luisa Foco, Peter P. Pramstaller, Karen Ocorr, Alessandra Rossini, Anthony Cammarato, Alexandre R. Colas, Andrew A. Hicks, Rolf Bodmer
Published 2020-07-01

PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2

by Sean A. Murphy, Matthew Miyamoto, Anaïs Kervadec, Suraj Kannan, Emmanouil Tampakakis, Sandeep Kambhampati, Brian Leei Lin, Sam Paek, Peter Andersen, Dong-Ik Lee, Renjun Zhu, Steven S. An, David A. Kass, Hideki Uosaki, Alexandre R. Colas, Chulan Kwon
Published 2021-03-01

Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells

by Maria A. Missinato, Sean Murphy, Michaela Lynott, Michael S. Yu, Anaïs Kervadec, Yu-Ling Chang, Suraj Kannan, Mafalda Loreti, Christopher Lee, Prashila Amatya, Hiroshi Tanaka, Chun-Teng Huang, Pier Lorenzo Puri, Chulan Kwon, Peter D. Adams, Li Qian, Alessandra Sacco, Peter Andersen, Alexandre R. Colas
Published 2023-03-01

Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

by Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer
Published 2020-10-01