Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load.

by Jonathan W Cody, Amy L Ellis-Connell, Shelby L O'Connor, Elsje Pienaar
Published 2023-08-01

Mathematical modeling of N-803 treatment in SIV-infected non-human primates.

by Jonathan W Cody, Amy L Ellis-Connell, Shelby L O'Connor, Elsje Pienaar
Published 2021-07-01

CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.

by Olivia E Harwood, Lea M Matschke, Ryan V Moriarty, Alexis J Balgeman, Abigail J Weaver, Amy L Ellis-Connell, Andrea M Weiler, Lee C Winchester, Courtney V Fletcher, Thomas C Friedrich, Brandon F Keele, David H O'Connor, Jessica D Lang, Matthew R Reynolds, Shelby L O'Connor
Published 2023-09-01