Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

by Ewan P. Plant, Deborah R. Taylor, Jonathan D. Dinman, Ralph S. Baric, Amy C. Sims
Published 2013-01-01

Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone

by Owen P. Leiser, Errett C. Hobbs, Amy C. Sims, George W. Korch, Karen L. Taylor
Published 2021-11-01

Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.

by Aartjan J W te Velthuis, Sjoerd H E van den Worm, Amy C Sims, Ralph S Baric, Eric J Snijder, Martijn J van Hemert
Published 2010-01-01

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

by Joshua M. Thornbrough, Babal K. Jha, Boyd Yount, Stephen A. Goldstein, Yize Li, Ruth Elliott, Amy C. Sims, Ralph S. Baric, Robert H. Silverman, Susan R. Weiss
Published 2016-05-01

Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung

by Fuyi Xu, Jun Gao, Jun Gao, Silke Bergmann, Amy C. Sims, David G. Ashbrook, Ralph S. Baric, Ralph S. Baric, Yan Cui, Colleen B. Jonsson, Kui Li, Robert W. Williams, Klaus Schughart, Klaus Schughart, Klaus Schughart, Lu Lu
Published 2021-01-01

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

by Vineet D. Menachery, Lisa E. Gralinski, Hugh D. Mitchell, Kenneth H. Dinnon, Sarah R. Leist, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Kelly G. Stratton, Adam S. Cockrell, Kari Debbink, Amy C. Sims, Katrina M. Waters, Ralph S. Baric
Published 2017-12-01

Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

by Amy C. Sims, Hugh D. Mitchell, Lisa E. Gralinski, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Mariam Lam, M. Leslie Fulcher, Ande West, Richard D. Smith, Scott H. Randell, Thomas O. Metz, Timothy P. Sheahan, Katrina M. Waters, Ralph S. Baric
Published 2021-08-01

The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections

by Hugh D. Mitchell, Amie J. Eisfeld, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Ji Wen, Jason E. McDermott, Lisa E. Gralinski, Amy C. Sims, Mai Q. Le, Ralph S. Baric, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Katrina M. Waters
Published 2019-09-01

Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection

by Ethan J. Fritch, Wes Sanders, Amy C. Sims, Laura E. Herring, Natalie K. Barker, Athena A. Schepmoes, Karl K. Weitz, Jordan R. Texier, Dirk P. Dittmer, Lee M. Graves, Richard D. Smith, Katrina M. Waters, Nathaniel J. Moorman, Ralph S. Baric, Rachel L. Graham
Published 2023-06-01

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

by Ernesto S. Nakayasu, Carrie D. Nicora, Amy C. Sims, Kristin E. Burnum-Johnson, Young-Mo Kim, Jennifer E. Kyle, Melissa M. Matzke, Anil K. Shukla, Rosalie K. Chu, Athena A. Schepmoes, Jon M. Jacobs, Ralph S. Baric, Bobbie-Jo Webb-Robertson, Richard D. Smith, Thomas O. Metz
Published 2016-06-01

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

by Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison
Published 2018-05-01

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

by Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Published 2020-01-01

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

by Vineet D. Menachery, Amie J. Eisfeld, Alexandra Schäfer, Laurence Josset, Amy C. Sims, Sean Proll, Shufang Fan, Chengjun Li, Gabriele Neumann, Susan C. Tilton, Jean Chang, Lisa E. Gralinski, Casey Long, Richard Green, Christopher M. Williams, Jeffrey Weiss, Melissa M. Matzke, Bobbie-Jo Webb-Robertson, Athena A. Schepmoes, Anil K. Shukla, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Michael G. Katze, Yoshihiro Kawaoka, Ralph S. Baric
Published 2014-07-01

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.

by Hugh D Mitchell, Amie J Eisfeld, Amy C Sims, Jason E McDermott, Melissa M Matzke, Bobbi-Jo M Webb-Robertson, Susan C Tilton, Nicolas Tchitchek, Laurence Josset, Chengjun Li, Amy L Ellis, Jean H Chang, Robert A Heegel, Maria L Luna, Athena A Schepmoes, Anil K Shukla, Thomas O Metz, Gabriele Neumann, Arndt G Benecke, Richard D Smith, Ralph S Baric, Yoshihiro Kawaoka, Michael G Katze, Katrina M Waters
Published 2013-01-01

Hypergraph models of biological networks to identify genes critical to pathogenic viral response

by Song Feng, Emily Heath, Brett Jefferson, Cliff Joslyn, Henry Kvinge, Hugh D. Mitchell, Brenda Praggastis, Amie J. Eisfeld, Amy C. Sims, Larissa B. Thackray, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff-Smith, Qing Tan, Vineet D. Menachery, Timothy P. Sheahan, Adam S. Cockrell, Jacob F. Kocher, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Michael S. Diamond, Ralph S. Baric, Katrina M. Waters, Yoshihiro Kawaoka, Jason E. McDermott, Emilie Purvine
Published 2021-05-01

A compendium of multi-omics data illuminating host responses to lethal human virus infections

by Amie J. Eisfeld, Lindsey N. Anderson, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff Smith, Larissa B. Thackray, Qing Tan, Amy C. Sims, Vineet D. Menachery, Alexandra Schäfer, Timothy P. Sheahan, Adam S. Cockrell, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Young-Mo Kim, Carrie D. Nicora, Zuleyma Peralta, Alhaji U. N’jai, Foday Sahr, Harm van Bakel, Michael S. Diamond, Ralph S. Baric, Thomas O. Metz, Richard D. Smith, Yoshihiro Kawaoka, Katrina M. Waters
Published 2024-04-01

Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections

by Lisa M. Bramer, Robert D. Hontz, Amie J. Eisfeld, Amy C. Sims, Young-Mo Kim, Kelly G. Stratton, Carrie D. Nicora, Marina A. Gritsenko, Athena A. Schepmoes, Osamu Akasaka, Michiko Koga, Takeya Tsutsumi, Morio Nakamura, Ichiro Nakachi, Rie Baba, Hiroki Tateno, Shoji Suzuki, Hideaki Nakajima, Hideaki Kato, Kazunari Ishida, Makoto Ishii, Yoshifumi Uwamino, Keiko Mitamura, Vanessa L. Paurus, Ernesto S. Nakayasu, Isaac K. Attah, Andrew G. Letizia, Katrina M. Waters, Thomas O. Metz, Karen Corson, Yoshihiro Kawaoka, Vincent R. Gerbasi, Hiroshi Yotsuyanagi, Kiyoko Iwatsuki-Horimoto
Published 2023-03-01