The potential of polygenic scores to improve cost and efficiency of clinical trials

by Akl C. Fahed, Anthony A. Philippakis, Amit V. Khera
Published 2022-05-01

Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank

by Aniruddh P. Patel, Manish D. Paranjpe, Nina P. Kathiresan, Manuel A. Rivas, Amit V. Khera
Published 2020-07-01

Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores

by Julian R. Homburger, Cynthia L. Neben, Gilad Mishne, Alicia Y. Zhou, Sekar Kathiresan, Amit V. Khera
Published 2019-11-01

Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study

by Melanie Zheng, Daniel Q. Huang, Chigoziri Konkwo, Saaket Agrawal, Amit V. Khera, Rohit Loomba, Sílvia Vilarinho, Veeral Ajmera
Published 2023-04-01

Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study

by Jae-Seung Yun, Sang-Hyuk Jung, Manu Shivakumar, Brenda Xiao, Amit V. Khera, Hong-Hee Won, Dokyoon Kim
Published 2022-07-01

Silhouette images enable estimation of body fat distribution and associated cardiometabolic risk

by Marcus D. R. Klarqvist, Saaket Agrawal, Nathaniel Diamant, Patrick T. Ellinor, Anthony Philippakis, Kenney Ng, Puneet Batra, Amit V. Khera
Published 2022-07-01

Prediction performance and fairness heterogeneity in cardiovascular risk models

by Uri Kartoun, Shaan Khurshid, Bum Chul Kwon, Aniruddh P. Patel, Puneet Batra, Anthony Philippakis, Amit V. Khera, Patrick T. Ellinor, Steven A. Lubitz, Kenney Ng
Published 2022-07-01

Estimated Yield of Screening for Heterozygous Familial Hypercholesterolemia With and Without Genetic Testing in US Adults

by Brandon K. Bellows, Amit V. Khera, Yiyi Zhang, Natalia Ruiz‐Negrón, Henry M. Stoddard, John B. Wong, Dhruv S. Kazi, Sarah D. de Ferranti, Andrew E. Moran
Published 2022-06-01

BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases

by Saaket Agrawal, Marcus D. R. Klarqvist, Nathaniel Diamant, Takara L. Stanley, Patrick T. Ellinor, Nehal N. Mehta, Anthony Philippakis, Kenney Ng, Melina Claussnitzer, Steven K. Grinspoon, Puneet Batra, Amit V. Khera
Published 2023-01-01

Clinical utility of polygenic scores for cardiometabolic disease in Arabs

by Injeong Shim, Hiroyuki Kuwahara, NingNing Chen, Mais O. Hashem, Lama AlAbdi, Mohamed Abouelhoda, Hong-Hee Won, Pradeep Natarajan, Patrick T. Ellinor, Amit V. Khera, Xin Gao, Fowzan S. Alkuraya, Akl C. Fahed
Published 2023-10-01

Design and user experience testing of a polygenic score report: a qualitative study of prospective users

by Deanna G. Brockman, Lia Petronio, Jacqueline S. Dron, Bum Chul Kwon, Trish Vosburg, Lisa Nip, Andrew Tang, Mary O’Reilly, Niall Lennon, Bang Wong, Kenney Ng, Katherine H. Huang, Akl C. Fahed, Amit V. Khera
Published 2021-10-01

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.

by Manish D Paranjpe, Mark Chaffin, Sohail Zahid, Scott Ritchie, Jerome I Rotter, Stephen S Rich, Robert Gerszten, Xiuqing Guo, Susan Heckbert, Russ Tracy, John Danesh, Eric S Lander, Michael Inouye, Sekar Kathiresan, Adam S Butterworth, Amit V Khera
Published 2022-09-01

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

by Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera
Published 2022-06-01

Abdominal subcutaneous adipose tissue negatively associates with subclinical coronary artery disease in men with psoriasis

by Meron Teklu, Wunan Zhou, Promita Kapoor, Nidhi Patel, Martin P Playford, Alexander V Sorokin, Amit K Dey, Heather L Teague, Grigory A Manyak, Justin A Rodante, Andrew Keel, Marcus Y Chen, David A Bluemke, Amit V Khera, Nehal N Mehta
Published 2021-12-01

Associations between polygenic risk of coronary artery disease and type 2 diabetes, lifestyle, and cardiovascular mortality: A prospective UK Biobank study

by Jae-Seung Yun, Jae-Seung Yun, Sang-Hyuk Jung, Sang-Hyuk Jung, Sang-Hyuk Jung, Manu Shivakumar, Manu Shivakumar, Manu Shivakumar, Brenda Xiao, Brenda Xiao, Amit V. Khera, Woong-Yang Park, Hong-Hee Won, Hong-Hee Won, Dokyoon Kim, Dokyoon Kim
Published 2022-08-01

GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

by Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra Chadwick, Christopher Cheng, Sara P. Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V. Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G. Rajeev, Andrew M. Bellinger
Published 2023-05-01

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

by Akl C. Fahed, Minxian Wang, Julian R. Homburger, Aniruddh P. Patel, Alexander G. Bick, Cynthia L. Neben, Carmen Lai, Deanna Brockman, Anthony Philippakis, Patrick T. Ellinor, Christopher A. Cassa, Matthew Lebo, Kenney Ng, Eric S. Lander, Alicia Y. Zhou, Sekar Kathiresan, Amit V. Khera
Published 2020-08-01

Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart,...

by Ann Marie Navar, Lawrence J. Fine, Walter T. Ambrosius, Arleen Brown, Pamela S. Douglas, Karen Johnson, Amit V. Khera, Donald Lloyd-Jones, Erin D. Michos, Mahasin Mujahid, Daniel Muñoz, Khurram Nasir, Nicole Redmond, Paul M Ridker, Jennifer Robinson, David Schopfer, Deborah F. Tate, Cora E. Lewis
Published 2022-12-01

Machine learning enables new insights into genetic contributions to liver fat accumulation

by Mary E. Haas, James P. Pirruccello, Samuel N. Friedman, Minxian Wang, Connor A. Emdin, Veeral H. Ajmera, Tracey G. Simon, Julian R. Homburger, Xiuqing Guo, Matthew Budoff, Kathleen E. Corey, Alicia Y. Zhou, Anthony Philippakis, Patrick T. Ellinor, Rohit Loomba, Puneet Batra, Amit V. Khera
Published 2021-12-01

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy

by James P. Pirruccello, Alexander Bick, Minxian Wang, Mark Chaffin, Samuel Friedman, Jie Yao, Xiuqing Guo, Bharath Ambale Venkatesh, Kent D. Taylor, Wendy S. Post, Stephen Rich, Joao A. C. Lima, Jerome I. Rotter, Anthony Philippakis, Steven A. Lubitz, Patrick T. Ellinor, Amit V. Khera, Sekar Kathiresan, Krishna G. Aragam
Published 2020-05-01