Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitor...

by Martin Winter, Roman P. Simon, Yuting Wang, Tom Bretschneider, Margit Bauer, Aniket Magarkar, Wolfgang Reindl, Amaury Fernández-Montalván, Florian Montel, Frank H. Büttner
Published 2022-07-01

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

by Anna P Baron, Conrad von Schubert, Fabien Cubizolles, Gerhard Siemeister, Marion Hitchcock, Anne Mengel, Jens Schröder, Amaury Fernández-Montalván, Franz von Nussbaum, Dominik Mumberg, Erich A Nigg
Published 2016-02-01

A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition

by Lilia Falkenstern, Victoria Georgi, Stefanie Bunse, Volker Badock, Manfred Husemann, Ulrike Roehn, Timo Stellfeld, Mark Fitzgerald, Steven Ferrara, Detlef Stöckigt, Carlo Stresemann, Ingo V. Hartung, Amaury Fernández-Montalván
Published 2024-01-01

Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis

by Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche, Oliver vonAhsen, Sylvia Grünewald, Holly M. Nguyen, Eva Corey, Simon J. Baumgart, Victoria Georgi, Vera Pütter, Amaury Fernández‐Montalván, James D. Vasta, Matthew B. Robers, Oliver Politz, Dominik Mumberg, Bernard Haendler
Published 2024-03-01