2.5 Å-resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942.

by Greber, Basil, Remis, Jonathan, Ali, Simak, NOGALES, Eva
Published 2021

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

by Periyasamy, Manikandan, Patel, Hetal, Lai, Chun-Fui, Nguyen, Van TM, Nevedomskaya, Ekaterina, Harrod, Alison, Russell, Roslin, Remenyi, Judit, Ochocka, Anna Maria, Thomas, Ross S, Fuller-Pace, Frances, Győrffy, Balázs, Caldas, Carlos, Navaratnam, Naveenan, Carroll, Jason S, Zwart, Wilbert, Coombes, R Charles, Magnani, Luca, Buluwela, Laki, Ali, Simak
Published 2019

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

by Martin, Lesley-Ann, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Pancholi, Sunil, Tenev, Tencho, Gellert, Pascal, Buluwela, Laki, Harrod, Alison, Thornhill, Allan, Nikitorowicz-Buniak, Joanna, Bhamra, Amandeep, Turgeon, Marc-Olivier, Poulogiannis, George, Gao, Qiong, Martins, Vera, Hills, Margaret, Garcia-Murillas, Isaac, Fribbens, Charlotte, Patani, Neill, Li, Zheqi, Sikora, Matthew J, Turner, Nicholas, Zwart, Wilbert, Oesterreich, Steffi, Carroll, Jason, Ali, Simak, Dowsett, Mitch
Published 2019

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.

by Ross-Innes, Caryn S, Stark, Rory, Teschendorff, Andrew E, Holmes, Kelly A, Ali, H Raza, Dunning, Mark J, Brown, Gordon D, Gojis, Ondrej, Ellis, Ian O, Green, Andrew R, Ali, Simak, Chin, Suet-Feung, Palmieri, Carlo, Caldas, Carlos, Carroll, Jason S
Published 2017

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.

by Periyasamy, Manikandan, Singh, Anup K, Gemma, Carolina, Kranjec, Christian, Farzan, Raed, Leach, Damien A, Navaratnam, Naveenan, Pálinkás, Hajnalka L, Vértessy, Beata G, Fenton, Tim R, Doorbar, John, Fuller-Pace, Frances, Meek, David W, Coombes, R Charles, Buluwela, Laki, Ali, Simak
Published 2018

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

by Lai, Chun-Fui, Flach, Koen D, Alexi, Xanthippi, Fox, Stephen P, Ottaviani, Silvia, Thiruchelvam, Paul TR, Kyle, Fiona J, Thomas, Ross S, Launchbury, Rosalind, Hua, Hui, Callaghan, Holly B, Carroll, Jason S, Charles Coombes, R, Zwart, Wilbert, Buluwela, Laki, Ali, Simak
Published 2019

Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer

by Giannoudis, Athina, Malki, Mohammed Imad, Rudraraju, Bharath, Mohhamed, Hisham, Menon, Suraj, Liloglou, Triantafillos, Ali, Simak, Carroll, Jason S., Palmieri, Carlo
Published 2020

Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer.

by Giannoudis, Athina, Malki, Mohammed Imad, Rudraraju, Bharath, Mohhamed, Hisham, Menon, Suraj, Liloglou, Triantafillos, Ali, Simak, Carroll, Jason S, Palmieri, Carlo
Published 2020

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.

by Li, Zheqi, Wu, Yang, Yates, Megan E, Tasdemir, Nilgun, Bahreini, Amir, Chen, Jian, Levine, Kevin M, Priedigkeit, Nolan M, Nasrazadani, Azadeh, Ali, Simak, Buluwela, Laki, Arnesen, Spencer, Gertz, Jason, Richer, Jennifer K, Troness, Benjamin, El-Ashry, Dorraya, Zhang, Qiang, Gerratana, Lorenzo, Zhang, Youbin, Cristofanilli, Massimo, Montanez, Maritza A, Sundd, Prithu, Wallace, Callen T, Watkins, Simon C, Fumagalli, Caterina, Guerini-Rocco, Elena, Zhu, Li, Tseng, George C, Wagle, Nikhil, Carroll, Jason S, Jank, Paul, Denkert, Carsten, Karsten, Maria M, Blohmer, Jens-Uwe, Park, Ben H, Lucas, Peter C, Atkinson, Jennifer M, Lee, Adrian V, Oesterreich, Steffi
Published 2022

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

by Eccles, Suzanne A, Aboagye, Eric O, Ali, Simak, Anderson, Annie S, Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P, Brennan, Keith, Brown, Nicola J, Bryant, Helen E, Bundred, Nigel J, Burchell, Joy M, Campbell, Anna M, Carroll, Jason S, Clarke, Robert B, Coles, Charlotte E, Cook, Gary JR, Cox, Angela, Curtin, Nicola J, Dekker, Lodewijk V, Silva, Isabel dos Santos, Duffy, Stephen W, Easton, Douglas F, Eccles, Diana M, Edwards, Dylan R, Edwards, Joanne, Evans, D, Fenlon, Deborah F, Flanagan, James M, Foster, Claire, Gallagher, William M, Garcia-Closas, Montserrat, Gee, Julia MW, Gescher, Andy J, Goh, Vicky, Groves, Ashley M, Harvey, Amanda J, Harvie, Michelle, Hennessy, Bryan T, Hiscox, Stephen, Holen, Ingunn, Howell, Sacha J, Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S, Jasani, Bharat, Jones, Louise J, Key, Timothy J, Kirwan, Cliona C, Kong, Anthony, Kunkler, Ian H, Langdon, Simon P, Leach, Martin O, Mann, David J, Marshall, John F, Martin, Lesley, Martin, Stewart G, Macdougall, Jennifer E, Miles, David W, Miller, William R, Morris, Joanna R, Moss, Sue M, Mullan, Paul, Natrajan, Rachel, O'Connor, James PB, O'Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul DP, Rakha, Emad A, Reed, Elizabeth, Robinson, Simon P, Sahai, Erik, Saxton, John M, Schmid, Peter, Smalley, Matthew J, Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H, Tutt, Andrew NJ, Velikova, Galina, Walker, Rosemary A, Watson, Christine J, Williams, Kaye J, Young, Leonie S, Thompson, Alastair M
Published 2019