Mechanistically transparent models for predicting aqueous solubility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression

by Alex Avdeef
Published 2023-08-01

Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs

by Alex Avdeef
Published 2014-04-01

In memoriam - Konstantin Tsinman (1968 - 2020)

by Alex Avdeef
Published 2022-12-01

Anomalous salting-out, self-association and pKa effects in the practically-insoluble bromothymol blue

by Alex Avdeef
Published 2023-05-01

Do you know your r2?

by Alex Avdeef
Published 2020-08-01

Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments

by Alex Avdeef
Published 2018-06-01

Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs

by Alex Avdeef
Published 2015-07-01

Solubility Temperature Dependence Predicted from 2D Structure

by Alex Avdeef
Published 2015-12-01

Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database

by Alex Avdeef
Published 2020-03-01

Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

by Alex Avdeef
Published 2019-08-01

Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation

by Alex Avdeef
Published 2022-12-01

Anomalous Solubility Behavior of Several Acidic Drugs

by Alex Avdeef
Published 2014-04-01

Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs?

by Alex Avdeef, Manfred Kansy
Published 2020-04-01

Perspectives in solubility measurement and interpretation

by Christel A.S. Bergström, Alex Avdeef
Published 2019-04-01

pKa-critical Interpretations of Solubility–pH Profiles: PG 300995 and NSC-639829 Case Studies

by George Butcher, John Comer, Alex Avdeef
Published 2015-07-01

Salt Solubility Products of Diprenorphine Hydrochloride, Codeine and Lidocaine Hydrochlorides and Phosphates – Novel Method of Data Analysis Not Dependent on Explicit Solubility Eq...

by Gergely Völgyi, Attila Marosi, Krisztina Takács-Novák, Alex Avdeef
Published 2013-12-01

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

by Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák
Published 2016-06-01

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Developm...

by Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez
Published 2022-01-01

Understanding the pH Dependence of Supersaturation State—A Case Study of Telmisartan

by Szabina Kádár, Dóra Csicsák, Petra Tőzsér, Attila Farkas, Tamás Pálla, Arash Mirzahosseini, Blanka Tóth, Gergő Tóth, Béla Fiser, Péter Horváth, János Madarász, Alex Avdeef, Krisztina Takács-Novák, Bálint Sinkó, Enikő Borbás, Gergely Völgyi
Published 2022-08-01