Variable or variate? A conundrum in pharmacometrics exposure–response models

by Ana‐Marija Grisic, Karthik Venkatakrishnan, Jonathan French, Akash Khandelwal
Published 2023-02-01

Model‐informed drug development supporting the approval of the avelumab flat‐dose regimen in patients with advanced renal cell carcinoma

by Joanna C. Masters, Akash Khandelwal, Alessandra diPietro, Haiqing Dai, Satjit Brar
Published 2022-04-01

Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study

by Ana‐Marija Grisic, Akash Khandelwal, Mauro Bertolino, Wilhelm Huisinga, Pascal Girard, Charlotte Kloft
Published 2020-11-01

Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non‐small cell lung cancer based on bintrafusp alfa trials

by Ana‐Marija Milenković‐Grišić, Nadia Terranova, Diane R. Mould, Yulia Vugmeyster, Thomas Mrowiec, Andreas Machl, Pascal Girard, Karthik Venkatakrishnan, Akash Khandelwal
Published 2024-01-01

A multistate modeling and simulation framework to learn dose–response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer

by Han Liu, Ana‐Marija Milenković‐Grišić, Sreenath M. Krishnan, Siv Jönsson, Lena E. Friberg, Pascal Girard, Karthik Venkatakrishnan, Yulia Vugmeyster, Akash Khandelwal, Mats O. Karlsson
Published 2023-11-01

Time‐Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma

by Justin J. Wilkins, Brigitte Brockhaus, Haiqing Dai, Yulia Vugmeyster, Joleen T. White, Satjit Brar, Carlo L. Bello, Berend Neuteboom, Janet R. Wade, Pascal Girard, Akash Khandelwal
Published 2019-06-01

Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab

by Nadia Terranova, Jonathan French, Haiqing Dai, Matthew Wiens, Akash Khandelwal, Ana Ruiz‐Garcia, Juliane Manitz, Anja vonHeydebreck, Mary Ruisi, Kevin Chin, Pascal Girard, Karthik Venkatakrishnan
Published 2022-03-01

Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma

by Ping Hu, Haiqing Isaac Dai, James Bourdage, Dongli Zhou, Ky Trang, Karey Kowalski, Carlo Bello, Jennifer Hibma, Akash Khandelwal, Kyra Cowan, Jennifer Dong, Karthik Venkatakrishnan, Wei Gao
Published 2024-03-01

Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside

by Akash Khandelwal, Francisca Arez, Paula M. Alves, Lassina Badolo, Catarina Brito, Christoph Fischli, Diana Fontinha, Claude Oeuvray, Miguel Prudêncio, Matthias Rottmann, Justin Wilkins, Özkan Yalkinoglu, Wilhelmina M. Bagchus, Thomas Spangenberg
Published 2022-05-01