High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.

by Adam Yasgar, Silviya D Furdas, David J Maloney, Ajit Jadhav, Manfred Jung, Anton Simeonov
Published 2012-01-01

A high-throughput approach for identification of novel general anesthetics.

by Wendy A Lea, Jin Xi, Ajit Jadhav, Louis Lu, Christopher P Austin, Anton Simeonov, Roderic G Eckenhoff
Published 2009-09-01

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

by Dorjbal Dorjsuren, Daemyung Kim, Vaddadi N Vyjayanti, David J Maloney, Ajit Jadhav, David M Wilson, Anton Simeonov
Published 2012-01-01

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

by Kinrin Yamanaka, Dorjbal Dorjsuren, Robert L Eoff, Martin Egli, David J Maloney, Ajit Jadhav, Anton Simeonov, R Stephen Lloyd
Published 2012-01-01

A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein.

by Joseph Carver, Thomas S Dexheimer, Dennis Hsu, Meng-Tzu Weng, Jordan L Smith, Rajarshi Guha, Ajit Jadhav, Anton Simeonov, Ji Luo
Published 2014-01-01

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

by Anton Simeonov, Avanti Kulkarni, Dorjbal Dorjsuren, Ajit Jadhav, Min Shen, Daniel R McNeill, Christopher P Austin, David M Wilson
Published 2009-06-01

A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2.

by J Brian Jameson, Auric Kantz, Lena Schultz, Chakrapani Kalyanaraman, Matthew P Jacobson, David J Maloney, Ajit Jadhav, Anton Simeonov, Theodore R Holman
Published 2014-01-01

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.

by Anton Simeonov, Ajit Jadhav, Ahmed A Sayed, Yuhong Wang, Michael E Nelson, Craig J Thomas, James Inglese, David L Williams, Christopher P Austin
Published 2008-01-01

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

by Adam Yasgar, Steven A Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J Maloney, Anton Simeonov, Natalia J Martinez
Published 2018-01-01

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

by Adam Yasgar, Steven A Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J Maloney, Anton Simeonov, Natalia J Martinez
Published 2017-01-01

Inhibition of DNA glycosylases via small molecule purine analogs.

by Aaron C Jacobs, Marcus J Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd
Published 2013-01-01

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

by Frank H Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J Maloney, Ewa S Pilka, Minghua Wang, Udo Oppermann, Tom D Heightman, Anton Simeonov
Published 2010-11-01

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).

by Joshua A Sommers, Tomasz Kulikowicz, Deborah L Croteau, Thomas Dexheimer, Dorjbal Dorjsuren, Ajit Jadhav, David J Maloney, Anton Simeonov, Vilhelm A Bohr, Robert M Brosh
Published 2019-01-01

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.

by Dorjbal Dorjsuren, Richard T Eastman, Min Jae Song, Adam Yasgar, Yuchi Chen, Kapil Bharti, Alexey V Zakharov, Ajit Jadhav, Marc Ferrer, Pei-Yong Shi, Anton Simeonov
Published 2022-01-01

Author Correction: A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells

by Rosita R. Asawa, Carina Danchik, Alexey Zakharov, Yuchi Chen, Ty Voss, Ajit Jadhav, Darren P. Wallace, Josephine F. Trott, Robert H. Weiss, Anton Simeonov, Natalia J. Martinez
Published 2022-10-01

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

by Ruili Huang, Ivan Grishagin, Yuhong Wang, Tongan Zhao, Jon Greene, John C. Obenauer, Deborah Ngan, Dac-Trung Nguyen, Rajarshi Guha, Ajit Jadhav, Noel Southall, Anton Simeonov, Christopher P. Austin
Published 2019-04-01

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

by Kelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A Freeman, David J Maloney, Anna Schwendeman, Alan T Remaley, Ajit Jadhav, John JG Tesmer
Published 2018-11-01

Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells

by Anju Singh, Myagmarjav Dashynam, Bryan Chim, Thelma M. Escobar, Xiuhuai Liu, Xin Hu, Samarjit Patnaik, Xin Xu, Noel Southall, Juan Marugan, Ajit Jadhav, Vanja Lazarevic, Stefan A. Muljo, Marc Ferrer
Published 2021-06-01

FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

by Katia A. Mesquita, Reem Ali, Rachel Doherty, Michael S. Toss, Islam Miligy, Adel Alblihy, Dorjbal Dorjsuren, Anton Simeonov, Ajit Jadhav, David M. Wilson, Ian Hickson, Natalie J. Tatum, Emad A. Rakha, Srinivasan Madhusudan
Published 2021-04-01

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

by Eric K Hoobler, Ganesha Rai, Andrew G S Warrilow, Steven C Perry, Christopher J Smyrniotis, Ajit Jadhav, Anton Simeonov, Josie E Parker, Diane E Kelly, David J Maloney, S L Kelly, Theodore R Holman
Published 2013-01-01