Genomic analyses of high‐grade neuroendocrine gynecological malignancies reveal a unique mutational landscape and therapeutic vulnerabilities

by Haider Mahdi, Amy Joehlin‐Price, Esther Elishaev, Afshin Dowlati, Ata Abbas
Published 2021-12-01

Post‐transcriptional regulation of PIAS3 expression by miR‐18a in malignant mesothelioma

by Tian He, Karen McColl, Nneha Sakre, Yanwen Chen, Gary Wildey, Afshin Dowlati
Published 2018-12-01

Pharmacogenomic approach to identify drug sensitivity in small-cell lung cancer.

by Gary Wildey, Yanwen Chen, Ian Lent, Lindsay Stetson, John Pink, Jill S Barnholtz-Sloan, Afshin Dowlati
Published 2014-01-01

Identification of Prognostic and Chemopredictive microRNAs for Non-Small-Cell Lung Cancer by Integrating SEER-Medicare Data

by Qing Ye, Joseph Putila, Rebecca Raese, Chunlin Dong, Yong Qian, Afshin Dowlati, Nancy Lan Guo
Published 2021-07-01

Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer

by Mohammad A. Shatat, Betsy Gauthier, Suzy Yoon, Eric Yuan, Peiying Yang, Goutham Narla, Afshin Dowlati, Richard T. Lee
Published 2023-04-01

A randomized controlled trial of structured palliative care versus standard supportive care for patients enrolled in phase 1 clinical trials

by Michelle Treasure, Barbara Daly, Shufen Cao, Pingfu Fu, Augustine Hong, Elizabeth Weinstein, Jessica Surdam, Neal J. Meropol, Afshin Dowlati
Published 2021-07-01

Novel Non-Invasive Radiomic Signature on CT Scans Predicts Response to Platinum-Based Chemotherapy and Is Prognostic of Overall Survival in Small Cell Lung Cancer

by Prantesh Jain, Mohammadhadi Khorrami, Amit Gupta, Prabhakar Rajiah, Kaustav Bera, Vidya Sankar Viswanathan, Pingfu Fu, Afshin Dowlati, Anant Madabhushi, Anant Madabhushi
Published 2021-10-01

Retinoblastoma mutation predicts poor outcomes in advanced non small cell lung cancer

by Priyanka Bhateja, Michelle Chiu, Gary Wildey, Mary Beth Lipka, Pingfu Fu, Michael Chiu Lee Yang, Fatemeh Ardeshir‐Larijani, Neelesh Sharma, Afshin Dowlati
Published 2019-04-01

A Phase 1, Open-Label, Dose-Escalation Study of L-DOS47 in Combination With Pemetrexed Plus Carboplatin in Patients With Stage IV Recurrent or Metastatic Nonsquamous NSCLC

by Sarina Piha-Paul, MD, George Simon, MD, Chandra P. Belani, MD, Heman Chao, PhD, Kim Gaspar, PhD, Brenda Lee, MSc, Afshin Dowlati, MD
Published 2022-11-01

Identification of RUNX1T1 as a potential epigenetic modifier in small‐cell lung cancer

by Tian He, Gary Wildey, Karen McColl, Alyssa Savadelis, Kyle Spainhower, Cassidy McColl, Adam Kresak, Aik Choon Tan, Michael Yang, Ata Abbas, Afshin Dowlati
Published 2021-01-01

Cardiovascular adverse events associated with BRAF versus BRAF/MEK inhibitor: Cross‐sectional and longitudinal analysis using two large national registries

by Avirup Guha, Prantesh Jain, Michael G. Fradley, Daniel Lenihan, Jahir M. Gutierrez, Chhavi Jain, Marcos deLima, Jill S. Barnholtz‐Sloan, Guilherme H. Oliveira, Afshin Dowlati, Sadeer Al‐Kindi
Published 2021-06-01

A Predictive 7-Gene Assay and Prognostic Protein Biomarkers for Non-small Cell Lung Cancer

by Nancy Lan Guo, Afshin Dowlati, Rebecca A. Raese, Chunlin Dong, Guoan Chen, David G. Beer, Justine Shaffer, Salvi Singh, Ujala Bokhary, Lin Liu, John Howington, Thomas Hensing, Yong Qian
Published 2018-06-01

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

by Robert Wesolowski, Neelesh Sharma, Laura Reebel, Mary Beth Rodal, Alexandra Peck, Brian L. West, Adhirai Marimuthu, Paul Severson, David A. Karlin, Afshin Dowlati, Mai H. Le, Lisa M. Coussens, Hope S. Rugo
Published 2019-06-01

Survival in elderly patients with breast cancer with and without autoimmune disease

by Demitrios Dedousis, Annie L. Zhang, Anastasia N. Vassiliou, Shufen Cao, Deepthi Yammani, Ravi K. Kyasaram, John P. Shanahan, Melissa C. Keinath, Melinda L. Hsu, Pingfu Fu, Afshin Dowlati, Alberto J. Montero
Published 2023-06-01

A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors

by James J. Harding, Ignacio Garrido-Laguna, Xiaoying Chen, Cynthia Basu, Afshin Dowlati, Alison Forgie, Andrea T. Hooper, Cris Kamperschroer, Steven I. Max, Steven I. Max, Allison Moreau, Megan Shannon, Gilbert Y. Wong, David S. Hong
Published 2022-04-01

369 Clinical update of VT1021, a first-in-class CD36 and CD47 targeting immunomodulating agent, in subjects with pancreatic cancer and other solid tumors stratified by novel biomar...

by Afshin Dowlati, Andrea Bullock, Susanna Ulahannan, Manish Patel, Shubham Pant, Marsha Crochiere, Jian Chen, Devalingam Mahalingam, Mary Mulcahy, Lou Vaickus, Suming Wang, Melanie Vincent, Michael Cieslewicz, Jing Watnick, Dejan Juric, Susanne Fyfe, Randolph Watnick
Published 2021-11-01

A Phase I Study of the Oral Dual-Acting Pan-PI3K/mTOR Inhibitor Bimiralisib in Patients with Advanced Solid Tumors

by Filip Janku, Grace M. Choong, Mateusz Opyrchal, Afshin Dowlati, Cinta Hierro, Jordi Rodon, Andreas Wicki, Martin D. Forster, Sarah P. Blagden, Jun Yin, Joel M. Reid, Helene Muller, Natasa Cmiljanovic, Vladimir Cmiljanovic, Alex A. Adjei
Published 2024-03-01

Effects of Rovalpituzumab Tesirine on Ventricular Repolarization in Patients With Small‐Cell Lung Cancer

by Jonathan W. Goldman, Minal Barve, Jyoti D. Patel, Antoinette Wozniak, Afshin Dowlati, Alexander Starodub, Taofeek K. Owonikoko, William Edenfield, Scott A. Laurie, Daniel Da Costa, Satwant Lally, Martina Koch, Matthew P. Kosloski, David Hoffman, Grace K. Dy
Published 2021-03-01

Validation of a liquid biopsy assay with molecular and clinical profiling of circulating tumor DNA

by Justin D. Finkle, Hala Boulos, Terri M. Driessen, Christine Lo, Richard A. Blidner, Ashraf Hafez, Aly A. Khan, Ariane Lozac’hmeur, Kelly E. McKinnon, Jason Perera, Wei Zhu, Afshin Dowlati, Kevin P. White, Robert Tell, Nike Beaubier
Published 2021-07-01

374 A first-in-human Phase 1/2 open label trial evaluating the safety, pharmacology, and preliminary efficacy of VT1021 in subjects with advanced solid tumors

by Afshin Dowlati, Andrea Bullock, Susanna Ulahannan, Manish Patel, Shubham Pant, Amita Patnaik, Marsha Crochiere, Devalingam Mahalingam, Wael Harb, Haider Mahdi, Manmeet Ahluwalia, Patrick Wen, Mary Mulcahy, Robert Guttendorf, Lou Vaickus, Suming Wang, Melanie Vincent, Michael Cieslewicz, Jing Watnick
Published 2020-11-01