TY  - JOUR
A1  - Ahmad, N.A.
A1  - Jumbri, K.
A1  - Ramli, A.
A1  - Ghani, N.A.
A1  - Ahmad, H.
A1  - Lim, J.W.
JF  - Molecules
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057742186&doi=10.3390%2fmolecules23123201&partnerID=40&md5=a5436eb036eec2fb1315fa54c9f20dfc
VL  - 23
Y1  - 2018///
PB  - MDPI AG
SN  - 14203049
N2  - The antiradical efficiency (AE) and kinetic behavior of a new ferulate-based protic ionic liquids (PILs) were described using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. The reduction of the DPPH free radical (DPPHâ?¢) was investigated by measuring the decrease in absorbance at 517 nm. The time to reach steady state for the reaction of parent acid (ferulic acid) and synthesized PILs with DPPHâ?¢ was continuously recorded for 1 h. Results revealed that the AE of 2-butylaminoethanol ferulate (2BAEF), 3-dimethylaminopropanol ferulate (3DMAPF) and 3-diethylaminopropanol ferulate (3DEAPF) PILs have improved compared to ferulic acid (FA) as the reaction class changes from low to medium. This attributed to the strong hydrogen abstraction occurred in the PILs. Furthermore, these PILs were found to have a good kinetic behavior compared to FA due to the high rate constant (k2) (164.17, 242.84 and 244.73 Mâ?? 1 sâ?? 1, respectively). The alkyl chain length and more alkyl substituents on the nitrogen atom of cation were believed to reduce the cation-anion interaction and speed up the hydrogen atom transfer (HAT) and electron transfer (ET) mechanisms; hence, increased rate constant was observed leading to a strong antioxidant activity of the synthesized PILs. © 2018 by the authors.
IS  - 12
N1  - cited By 12
TI  - A kinetic approach of DPPH free radical assay of ferulate-based protic ionic liquids (PILs)
ID  - scholars9495
KW  - 1
KW  - 1-diphenyl-2-picrylhydrazyl; biphenyl derivative; coumaric acid; ferulic acid; ionic liquid; picric acid; scavenger
KW  -  antagonists and inhibitors; bioassay; chemical structure; chemistry; dose response; kinetics; procedures
KW  -  Biological Assay; Biphenyl Compounds; Coumaric Acids; Dose-Response Relationship
KW  -  Drug; Free Radical Scavengers; Ionic Liquids; Kinetics; Molecular Structure; Picrates
AV  - none
ER  -