relation: https://khub.utp.edu.my/scholars/8886/
title: A wavelet-based technique to predict treatment outcome for Major Depressive Disorder
creator: Mumtaz, W.
creator: Xia, L.
creator: Yasin, M.A.M.
creator: Ali, S.S.A.
creator: Malik, A.S.
description: Treatment management for Major Depressive Disorder (MDD) has been challenging. However, electroencephalogram (EEG)-based predictions of antidepressant's treatment outcome may help during antidepressant's selection and ultimately improve the quality of life for MDD patients. In this study, a machine learning (ML) method involving pretreatment EEG data was proposed to perform such predictions for Selective Serotonin Reuptake Inhibitor (SSRIs). For this purpose, the acquisition of experimental data involved 34 MDD patients and 30 healthy controls. Consequently, a feature matrix was constructed involving time-frequency decomposition of EEG data based on wavelet transform (WT) analysis, termed as EEG data matrix. However, the resultant EEG data matrix had high dimensionality. Therefore, dimension reduction was performed based on a rank-based feature selection method according to a criterion, i.e., receiver operating characteristic (ROC). As a result, the most significant features were identified and further be utilized during the training and testing of a classification model, i.e., the logistic regression (LR) classifier. Finally, the LR model was validated with 100 iterations of 10-fold cross-validation (10-CV). The classification results were compared with short-Time Fourier transform (STFT) analysis, and empirical mode decompositions (EMD). The wavelet features extracted from frontal and temporal EEG data were found statistically significant. In comparison with other time-frequency approaches such as the STFT and EMD, the WT analysis has shown highest classification accuracy, i.e., accuracy = 87.5, sensitivity = 95, and specificity = 80. In conclusion, significant wavelet coefficients extracted from frontal and temporal pre-Treatment EEG data involving delta and theta frequency bands may predict antidepressant's treatment outcome for the MDD patients. © 2017 Mumtaz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publisher: Public Library of Science
date: 2017
type: Article
type: PeerReviewed
identifier:   Mumtaz, W. and Xia, L. and Yasin, M.A.M. and Ali, S.S.A. and Malik, A.S.  (2017) A wavelet-based technique to predict treatment outcome for Major Depressive Disorder.  PLoS ONE, 12 (2).   ISSN 19326203     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011342704&doi=10.1371%2fjournal.pone.0171409&partnerID=40&md5=ac1c9b8eb39b68bb44ba3be67dfa8b38
relation: 10.1371/journal.pone.0171409
identifier: 10.1371/journal.pone.0171409