TY  - JOUR
KW  - Biomedical signal processing; Codes (symbols); DNA; Fuzzy logic; Gene encoding; Nucleotides; Proteins; Semantics
KW  -  1/F noise; 3-base periodicity; Coding region; Computational solutions; Fundamental characteristics; Non-coding region; Protein coding regions; Semantic similarity
KW  -  Digital signal processing
KW  -  DNA; nucleotide
KW  -  codon; digital filtering; DNA sequence; Fourier transformation; genetic code; human; molecular weight; noise reduction; nonhuman; pathogenicity island; priority journal; Review; signal processing
ID  - scholars8758
N2  - Protein coding regions are commonly diffused with non-coding regions due to 1/f background noise in such a way that a viable discernment between the two regions becomes cumbersome. Commonly employed digital signal processing methodologies lack fundamental genetic code context of nucleotides since these approaches treat DNA signal as normal digital signal that could be processed by traditional DSP tools and techniques. This paper reviews the prevailing approaches for protein coding regions identification that base on common DSP concepts and highlights the importance of genetic code context to be considered for any computational solution for protein coding regions identification. Nucleotides in a DNA signal carry certain natural characteristics i.e. presence in a distinctive triplet format, maintaining distinct structure, owning and further sharing distribution of densities in codons, fuzzy behaviors, semantic similarities, unbalanced nucleotidesâ?? distribution producing a relatively high bias for nucleotidesâ?? usage in coding regions etc. The computational solutions for protein coding regions identification that exploit these fundamental characteristic of nucleotides can significantly suppress the signal noise and hence can better contribute in identification. © 2017 Elsevier Ltd
Y1  - 2017///
VL  - 34
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009382823&doi=10.1016%2fj.bspc.2017.01.004&partnerID=40&md5=51c5c9971586722bc8bac4fd29a6547b
JF  - Biomedical Signal Processing and Control
A1  - Ahmad, M.
A1  - Jung, L.T.
A1  - Bhuiyan, A.-A.
AV  - none
SP  - 44
TI  - From DNA to protein: Why genetic code context of nucleotides for DNA signal processing? A review
N1  - cited By 32
SN  - 17468094
PB  - Elsevier Ltd
EP  - 63
ER  -