relation: https://khub.utp.edu.my/scholars/8758/
title: From DNA to protein: Why genetic code context of nucleotides for DNA signal processing? A review
creator: Ahmad, M.
creator: Jung, L.T.
creator: Bhuiyan, A.-A.
description: Protein coding regions are commonly diffused with non-coding regions due to 1/f background noise in such a way that a viable discernment between the two regions becomes cumbersome. Commonly employed digital signal processing methodologies lack fundamental genetic code context of nucleotides since these approaches treat DNA signal as normal digital signal that could be processed by traditional DSP tools and techniques. This paper reviews the prevailing approaches for protein coding regions identification that base on common DSP concepts and highlights the importance of genetic code context to be considered for any computational solution for protein coding regions identification. Nucleotides in a DNA signal carry certain natural characteristics i.e. presence in a distinctive triplet format, maintaining distinct structure, owning and further sharing distribution of densities in codons, fuzzy behaviors, semantic similarities, unbalanced nucleotides� distribution producing a relatively high bias for nucleotides� usage in coding regions etc. The computational solutions for protein coding regions identification that exploit these fundamental characteristic of nucleotides can significantly suppress the signal noise and hence can better contribute in identification. © 2017 Elsevier Ltd
publisher: Elsevier Ltd
date: 2017
type: Article
type: PeerReviewed
identifier:   Ahmad, M. and Jung, L.T. and Bhuiyan, A.-A.  (2017) From DNA to protein: Why genetic code context of nucleotides for DNA signal processing? A review.  Biomedical Signal Processing and Control, 34.  pp. 44-63.  ISSN 17468094     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009382823&doi=10.1016%2fj.bspc.2017.01.004&partnerID=40&md5=51c5c9971586722bc8bac4fd29a6547b
relation: 10.1016/j.bspc.2017.01.004
identifier: 10.1016/j.bspc.2017.01.004