TY  - JOUR
PB  - Public Library of Science
SN  - 19326203
Y1  - 2017///
VL  - 12
JF  - PLoS ONE
A1  - Bhatti, M.S.
A1  - Tang, T.B.
A1  - Laude, A.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025164854&doi=10.1371%2fjournal.pone.0181512&partnerID=40&md5=72ade22249c588c53f41338d718d2df8
AV  - none
TI  - Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
ID  - scholars8558
KW  - adult; Article; autoregulation; controlled study; female; fluid intake; human; informed consent; intraocular pressure; laser speckle flowgraphy; male; mean blur rate; ocular blood flow; ocular blood vessel; optic nerve; optic nerve head; visual system parameters; water loading; blood flow; blood flow velocity; choroid; drinking; eye; laser Doppler flowmetry; microcirculation; procedures; vascularization; young adult
KW  -  Adult; Blood Flow Velocity; Choroid; Drinking; Eye; Humans; Laser-Doppler Flowmetry; Microcirculation; Regional Blood Flow; Young Adult
N2  - The water-drinking test (WDT) is a provocative test used in glaucoma research to assess the effects of elevated intraocular pressure (IOP). Defective autoregulation due to changes in perfusion pressure may play a role in the pathophysiology of several ocular diseases. This study aims to examine the effects of WDT on ocular blood flow (in the form of pulse waveform parameters obtained using laser speckle flowgraphy) to gain insight into the physiology of ocular blood flow and its autoregulation in healthy individuals. Changes in pulse waveform parameters of mean blur rate (MBR) in the entire optic nerve head (ONH), the vasculature of the ONH, the tissue area of the ONH, and the avascular tissue area located outside of the ONH were monitored over time. Significant increases in the falling rate of MBR over the entire ONH and its tissue area and decreases in blowout time (BOT) of the tissue area were observed only at 10 minutes after water intake. Significant increases in the skew of the waveform and the falling rate were observed in the vasculature of the ONH at 40 and 50 minutes after water intake, respectively. In the avascular region of the choroid, the average MBR increased significantly up to 30 minutes after water intake. Furthermore, the rising rate in this region increased significantly at 20 and 40 minutes, and the falling rate and acceleration-time index were both significantly increased at 40 minutes after water intake. Our results indicate the presence of effective autoregulation of blood flow at the ONH after WDT. However, in the choroidal region, outside of the ONH, effective autoregulation was not observed until 30 minutes after water intake in healthy study participants. These pulse waveform parameters could potentially be used in the diagnosis and/or monitoring of patients with glaucoma. © 2017 Bhatti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
IS  - 7
N1  - cited By 8
ER  -