eprintid: 8297 rev_number: 2 eprint_status: archive userid: 1 dir: disk0/00/00/82/97 datestamp: 2023-11-09 16:20:11 lastmod: 2023-11-09 16:20:11 status_changed: 2023-11-09 16:12:18 type: article metadata_visibility: show creators_name: Goh, C.M. creators_name: Subramaniam, R. creators_name: Saad, N.M. creators_name: Ali, S.A. creators_name: Meriaudeau, F. title: Subcutaneous veins depth measurement using diffuse reflectance images ispublished: pub keywords: Monte Carlo methods; Ultrasonic measurement; Ultrasonic waves, Diffuse reflectance; Excess pressure; Experimental demonstrations; Experimental trials; Isosbestic wavelengths; Proof of principles; Ultrasound measurement; Vascular access, Reflection, algorithm; anatomy and histology; diagnostic imaging; echography; human; light; light related phenomena; Monte Carlo method; pressure; proof of concept; reproducibility; skin; skin pigmentation; validation study; vascularization; vein, Algorithms; Humans; Light; Monte Carlo Method; Optical Phenomena; Pressure; Proof of Concept Study; Reproducibility of Results; Skin; Skin Pigmentation; Ultrasonography; Veins note: cited By 15 abstract: Intravenous (IV) procedures are often difficult due to the poor visualization of subcutaneous veins. Because existing vein locators lack the ability to assess depth, and also because mis-punctures and poor vascular access remain problematic, we propose an imaging system that employs diffuse reflectance images at three isosbestic wavelengths to measure both the depth and thickness of subcutaneous veins. This paper describes the proposed system as well as proof-of-principle experimental demonstrations. We initially introduce the working principle and structure of the system. All measurements were based on the Monte Carlo (MC) method and accomplished by referring an optical density (OD) ratio to a multi-layer diffuse reflectance model. Results were all validated by comparative ultrasound measurements. Experimental trials included 11 volunteers who were subjected to both ultrasound measurements and the proposed optical process to validate the system�s applicability. However, the unreliability of the �thickness� measurement of the vein may be due to the fact that the veins have collapsible walls � so excess pressure by the transducer will give a false thickness. © 2017 Optical Society of America date: 2017 publisher: OSA - The Optical Society official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031795983&doi=10.1364%2fOE.25.025741&partnerID=40&md5=1bae390738efcbfc787013c75f29064e id_number: 10.1364/OE.25.025741 full_text_status: none publication: Optics Express volume: 25 number: 21 pagerange: 25741-25759 refereed: TRUE issn: 10944087 citation: Goh, C.M. and Subramaniam, R. and Saad, N.M. and Ali, S.A. and Meriaudeau, F. (2017) Subcutaneous veins depth measurement using diffuse reflectance images. Optics Express, 25 (21). pp. 25741-25759. ISSN 10944087